抗IL-17C抗体(Anti-IL-17C, Human, Mouse-Mono antibody)
掲載日情報：2021/01/28 現在Webページ番号：28207
IL-17Cに対する抗体(Anti-IL-17C, Human, Mouse-Mono )です。
※ 本製品は研究用です。研究用以外には使用できません。
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- 価格
- Product Details
- Applications and Data
- Data Examples
- References
- Related Research Areas
- Related Product & Information
- Citations
価格
[在庫・価格 ：2025年04月26日 20時55分現在]
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Anti-IL-17C, Human, Mouse-Mono(177114) |
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Anti-Human IL-17C MAb (Clone 177114) |
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[在庫・価格 ：2025年04月26日 20時55分現在]
Anti-IL-17C, Human, Mouse-Mono(177114)
文献数： 1
- 商品コード：MAB1234
- メーカー：RSD
- 包装：500μg
- 価格：¥123,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | マッチドペア：Human IL-17C サンドイッチELISAの補足用抗体として利用可能，検出用抗体として#BAF1234，スタンダードとして#1234-IL-025を用いる。 別名：CX2 クローン：177114 Genbank No： 27189 Protein Accession No： Q9P0M4.1 |
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| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | -20℃ | 法規備考 | |||||
| 抗原種 | Human | 免疫動物 | Mouse | ||||
| 交差性 | Human | 適用 | ELISA,FCM,IHC,Western Blot | ||||
| 標識 | Unlabeled | 性状 | Protein A/G Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Monoclonal | フォーマット | |||||
| 掲載カタログ |
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| 製品記事 | Helper T Cells Marker Antibodies |
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| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Anti-Human IL-17C MAb (Clone 177114)
文献数： 0
- 商品コード：MAB1234-SP
- メーカー：RSD
- 包装：25μg
- 価格：¥30,000
- 在庫：無(未発注)
- 納期：2～3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | ※受注発注品。形状：溶液または凍結乾燥 別名：CX2 クローン：177114 Genbank No： 27189 Protein Accession No： Q9P0M4.1 |
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| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | -20℃ | 法規備考 | |||||
| 抗原種 | 免疫動物 | Mouse | |||||
| 交差性 | Human | 適用 | ELISA,FCM,IHC,Western Blot | ||||
| 標識 | Unlabeled | 性状 | Protein A/G Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Monoclonal | フォーマット | |||||
| 掲載カタログ |
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| 製品記事 | 使いっきり抗体 |
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| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Product Details
| Species Reactivity | Human |
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| Label | Unconjugated |
| Immunogen | E. coli-derived recombinant human IL‑17CHis19-Val197Accession # Q9P0M4.1 |
| Source | Monoclonal Mouse IgG2A Clone # 177114 |
| Purification | Protein A or G purified from hybridoma culture supernatant |
| Specificity | Detects human IL-17C in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human IL-17A, B, D, E or F is observed. |
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Applications and Data
| Recommended Concentration | Sample | |
| Western Blot | 1 µg/mL | Recombinant Human IL‑17C (Catalog # 1234-IL) |
| Immunohistochemistry | 5-25 µg/mL | See below |
| CyTOF-ready | Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation. | |
| Intracellular Staining by Flow Cytometry | 0.25 µg/106 cells | See below |
| Human IL-17C Sandwich Immunoassay | Reagent | |
| ELISA Capture (Matched Antibody Pair) | 2-8 µg/mL | Human IL‑17C Antibody (Catalog #MAB1234 ) |
| ELISA Detection (Matched Antibody Pair) | 0.1-0.4 µg/mL | Human IL‑17C Biotinylated Antibody (Catalog #BAF1234 ) |
| ELISA Standard | Recombinant Human IL-17C Protein (Catalog #1234-IL ) | |
| Please Note: Optimal dilutions should be determined by each laboratory for each application.General Protocolsare available in the Technical Information section on our website. | ||
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Data Examples
| Immunohistochemistry |
![Immunohistochemistry IL-17C Antibody (177114) [Unconjugated]](http://resources.rndsystems.com/images/datasheets/antibody/IL17C_MAB1234_Immunohistochemistry_20070.jpg) click image to view larger | IL‑17C in Human Skin. IL‑17C was detected in immersion fixed paraffin-embedded sections of human psoriatic skin using Mouse Anti-Human IL‑17C Monoclonal Antibody (Catalog # MAB1234) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). Specific staining was localized to keratinocytes. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections. |
| Intracellular Staining by Flow Cytometry |
![Intracellular Staining by Flow Cytometry IL-17C Antibody (177114) [Unconjugated]](http://resources.rndsystems.com/images/datasheets/antibody/IL-17C_MAB1234_Flow_Cytometry_8330.jpg) click image to view larger | Detection of IL‑17C in PC‑3 Human Cell Line by Flow Cytometry.PC‑3 human prostate cancer cell line was stained with Mouse Anti-Human IL‑17C Monoclonal Antibody (Catalog # MAB1234, filled histogram) or isotype control antibody (Catalog # MAB003, open histogram), followed by Allophycocyanin-conjugated Anti-Mouse IgG F(ab')2 Secondary Antibody (Catalog # F0101B). To facilitate intracellular staining, cells were fixed with paraformaldehyde and permeabilized with saponin. |
| Reconstitution | Reconstitute at 0.5 mg/mL in sterile PBS. | Reconstitution Buffer Available |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C | |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. | |
| 1 month, 2 to 8 °C under sterile conditions after reconstitution. | ||
| 6 months, -20 to -70 °C under sterile conditions after reconstitution. | ||
| Background: IL-17C | The Interleukin-17 (IL-17) family proteins, comprising six members (IL-17, IL-17B through IL-17F), are secreted, structurally related proteins that share a conserved cysteine-knot fold near the C-terminus, but have considerable sequence divergence at the N-terminus (1, 2). With the exception of IL-17B, which exists as a non‑covalently linked dimer, all IL‑17 family members are disulfide-linked dimers (3). IL-17 family proteins are pro-inflammatory cytokines that induce local cytokine production and are involved in the regulation of immune functions (1, 2). Two receptors (IL-17 R, and IL-17B R), which are activated by IL-17 family members, have been identified. In addition, at least three additional orphan type I transmembrane receptors with homology to IL-17 R, including IL-17 RL (IL-17 RC), IL-17 RD, and IL‑17 RE, have also been reported (1‑4). Human IL-17C cDNA encodes a 197 amino acid (aa) residues protein with a putative 18 aa signal peptide (5). IL-17C shares from 15%‑30% aa sequence identity with other IL-17 family members. Human and mouse IL-17C also share 83% aa sequence identity. IL-17C has a very restricted expression pattern and was detected as a rare expressed sequence tag (EST) sequence in an adult prostate and fetal kidney libraries (2). IL-17C has been shown to stimulate the release of TNF-alpha and IL-1 beta from the monocytic cell line THP-1, a property it shares with IL-17B (5, 6). |
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References
| Aggarwal, S. and A.L. Gurney (2002) J. Leukoc. Biol. 71:1. | |
| Moseley, T.A. et al. (2003) Cytokine & Growth Factor Rev. 14:155. | |
| Hymowitz, S.G. et al. (2001) EMBO J. 20:5332. | |
| Haudenschild, D. et al. (2002) J. Biol. Chem. 277:4309. | |
| Li, H. et al. (2000) Proc. Natl. Acad. Sci. USA 97:773. | |
| Shi, Y. et al. (2000) J. Biol. Chem. 275:19167. | |
| Long Name: | Interleukin 17C |
| Entrez Gene IDs: | 27189 (Human); 234836 (Mouse) |
| Alternate Names: | CX2; Cytokine CX2; IL17C; IL-17C; IL-17CMGC126884; interleukin 17C; interleukin-17C; MGC138401 |
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Related Research Areas
| Helper T (Th) Cells | ||
| IL-17 Family | ||
| Th17 Cells | ||
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| Immunohistochemistry | |
|---|---|
 | IL‑17C in Human Skin. IL‑17C was detected in immersion fixed paraffin-embedded sections of human psoriatic skin using Mouse Anti-Human IL‑17C Monoclonal Antibody (Catalog # MAB1234) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). Specific staining was localized to keratinocytes. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections. |
| Intracellular Staining by Flow Cytometry | |
 | Detection of IL‑17C in PC‑3 Human Cell Line by Flow Cytometry. PC‑3 human prostate cancer cell line was stained with Mouse Anti-Human IL‑17C Monoclonal Antibody (Catalog # MAB1234, filled histogram) or isotype control antibody (Catalog # MAB003, open histogram), followed by Allophycocyanin-conjugated Anti-Mouse IgG F(ab')2 Secondary Antibody (Catalog # F0101B). To facilitate intracellular staining, cells were fixed with paraformaldehyde and permeabilized with saponin. |
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Related Product & Information
| Background | IL-17C |
|---|---|
| background_content | Background: IL-17C The Interleukin-17 (IL-17) family proteins, comprising six members (IL-17, IL-17B through IL-17F), are secreted, structurally related proteins that share a conserved cysteine-knot fold near the C-terminus, but have considerable sequence divergence at the N-terminus (1, 2). With the exception of IL-17B, which exists as a non‑covalently linked dimer, all IL‑17 family members are disulfide-linked dimers (3). IL-17 family proteins are pro-inflammatory cytokines that induce local cytokine production and are involved in the regulation of immune functions (1, 2). Two receptors (IL-17 R, and IL-17B R), which are activated by IL-17 family members, have been identified. In addition, at least three additional orphan type I transmembrane receptors with homology to IL-17 R, including IL-17 RL (IL-17 RC), IL-17 RD, and IL‑17 RE, have also been reported (1‑4). Human IL-17C cDNA encodes a 197 amino acid (aa) residues protein with a putative 18 aa signal peptide (5). IL-17C shares from 15%‑30% aa sequence identity with other IL-17 family members. Human and mouse IL-17C also share 83% aa sequence identity. IL-17C has a very restricted expression pattern and was detected as a rare expressed sequence tag (EST) sequence in an adult prostate and fetal kidney libraries (2). IL-17C has been shown to stimulate the release of TNF-alpha and IL-1 beta from the monocytic cell line THP-1, a property it shares with IL-17B (5, 6). |
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Citations
- Activity-dependent synaptic Wnt release regulates hippocampal long term potentiation.
Authors: Chen J, Park CS, Tang SJ
J. Biol. Chem., 2006;281(17):11910-6.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC Paraffin-embedded
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