抗Human IL-4 R alpha Phycoerythrin抗体(Anti-Human IL-4 R alpha Phycoerythrin antibody)

• 価格
• Product Details
• Applications and Data
• Related Product & Information
• Citations

価格

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Product Details

Species Reactivity	Human
Label	Phycoerythrin
Immunogen	S. frugiperda insect ovarian cell line Sf 21-derived recombinant human IL‑4 RGly24-His232Accession # P24394
Source	Monoclonal Mouse IgG2A Clone # 25463
Purification	Protein A or G purified from ascites
Specificity	Detects human IL‑4 R alpha in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human (rh) IL-9 R, recombinant mouse IL-4 R, rhIL-5 R alpha, rhIL-5 R beta, rhIL-13 R alpha 1, or rhIL-13 R alpha 2 is observed.

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Applications and Data

	Recommended Concentration	Sample
Flow Cytometry	10 µL/106 cells	See below

Flow Cytometry
	Detection of IL‑4 R alpha in Daudi Human Cell Line by Flow Cytometry. Daudi human Burkitt's lymphoma cell line was stained with Mouse Anti-Human IL‑4 R alpha PE‑conjugated Monoclonal Antibody (Catalog # FAB230P, filled histogram) or isotype control antibody (Catalog # IC003P, open histogram). View our protocol for Staining Membrane-associated Proteins.

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Related Product & Information

Long Name	Interleukin 4 Receptor alpha
Background	IL-4 R alpha
background_content	Background: IL-4 R alpha Interleukin 4 receptor (IL-4 R) is the transmembrane ligand binding subunit of the heterodimeric IL-4 receptor complex. In the type I receptor complex, IL-4 R associates with the common gamma chain, whereas in the type II receptor complex, it associates with IL-13 R alpha 1. IL-4 R is expressed by B cells, T cells, monocytes and macrophages.

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Citations

1. Neutrophil Extracellular Traps Reprogram IL-4/GM-CSF-Induced Monocyte Differentiation to Anti-inflammatory Macrophages
   Authors: AB Guimarães-, NC Rochael, F Oliveira, J Echevarria, EM Saraiva
   Front Immunol, 2017;8(0):523.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


2. Chimeric rat/human HER2 efficiently circumvents HER2 tolerance in cancer patients.
   Authors: Occhipinti S, Sponton L, Rolla S, Caorsi C, Novarino A, Donadio M, Bustreo S, Satolli M, Pecchioni C, Marchini C, Amici A, Cavallo F, Cappello P, Pierobon D, Novelli F, Giovarelli M
   Clin Cancer Res, 2014;20(11):2910-21.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


3. IL4Ralpha+ myeloid-derived suppressor cell expansion in cancer patients.
   Authors: Mandruzzato S, Solito S, Falisi E, Francescato S, Chiarion-Sileni V, Mocellin S, Zanon A, Rossi CR, Nitti D, Bronte V, Zanovello P
   J. Immunol., 2009;182(10):6562-8.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


4. MEK1/2 induces STAT5-mediated germline transcription of the TCRgamma locus in response to IL-7R signaling.
   Authors: Maki K, Ikuta K
   J. Immunol., 2008;181(1):494-502.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow

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