抗IFN-alpha抗体(Anti-IFN-α, Mouse, Rabbit-Poly antibody)

• 価格
• Product Details
• Applications and Data
• Related Product & Information
• Citations

価格

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Product Details

Species Reactivity	Mouse
Label	Unconjugated
Immunogen	E. coli-derived recombinant mouse IFN-alpha A
Source	Polyclonal Rabbit Serum
Purification	N/A
Specificity	Mouse IFN-alpha

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Applications and Data

	Recommended Concentration	Sample
Neutralization	One Neutralization Unit (NU) is the amount of antiserum required to neutralize one unit of mouse interferon alpha (Mu-IFN-alpha ) to a 50% endpoint. Interferon was titrated with the use of the cytopathic effect inhibition assay using L929 cells as described [Rubinstein, S., Familletti, P.C., and Pestka, S. (1981) "Convenient Assay for Interferons," J. Virol. 37, 755-758] with the exception that EMCV was used as the challenge virus. In this antiviral assay for interferon, about 5 unit/ml of interferon is the quantity necessary to produce a cytopathic effect of 50%. The units are determined with respect to the international reference standard for Mu-IFN-alpha provided by the National Institutes of Health [Ga02-901-511). This material is prepared specifically for effective neutralization of Mu-IFN-alpha.

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Related Product & Information

Long Name	Interferon alpha
Background	IFN-alpha
background_content	Background: IFN-alpha Interferon-alpha (IFN-alpha), also known as leukocyte interferon, represents a group of related but distinct proteins that share over 95% amino acid sequence homology. They are members of the type I interferon family which share a common cell surface receptor composed of two subunits, a 100 kDa ligand-binding subunit (IFN-alpha R2) and a 125 kDa ligand binding and signal transduction subunit (IFN-alpha R1) that is involved both in ligand binding and signal transduction. IFN-alpha has both anti-viral and immunomodulatory activities on target cells.

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Citations

1. Identification of Toll-like receptor 9 as parapoxvirus ovis-sensing receptor in plasmacytoid dendritic cells.
   Authors: von Buttlar H, Siegemund S, Buttner M, Alber G
   PLoS ONE, 2014;9(8):e106188.
   Species: Mouse
   Sample Type: Cell Culture Supernates
   Application: ELISA Development


2. A role for Stat1 in the regulation of lipopolysaccharide-induced interleukin-1beta expression.
   Authors: Joshi VD, Kalvakolanu DV, Chen W, Zhang L, Kang TJ, Thomas KE, Vogel SN, Cross AS
   J. Interferon Cytokine Res., 2006;26(10):739-47.
   Species: Mouse
   Sample Type: Serum
   Application: ELISA Development

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