抗GM-CSF抗体(Anti-GM-CSF, Mouse-Mono antibody)
掲載日情報：2021/01/28 現在Webページ番号：27962
GM-CSFに対する抗体(Anti-GM-CSF, Mouse-Mono )です。
※ 本製品は研究用です。研究用以外には使用できません。
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- 価格
- Product Details
- Applications and Data
- References
- Related Research Areas
- Related Product & Information
価格
[在庫・価格 ：2024年05月19日 00時00分現在]
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Anti-GM-CSF, Mouse-Mono(159315) |
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[在庫・価格 ：2024年05月19日 00時00分現在]
Anti-GM-CSF, Mouse-Mono(159315)
文献数： 0
- 商品コード：BAM9873
- メーカー：RSD
- 包装：250μg
- 価格：¥115,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 |
マッチドペア：Feline GM-CSF サンドイッチELISAの検出用抗体として利用可能，補足用抗体として#MAB9872，スタンダードとして#987-FL-010を用いる。 別名：colony stimulating factor 2 (granulocyte-macrophage) クローン：159319 Genbank No： 1437 Protein Accession No： AAC06041 |
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| 法規制等 | |||
| 保存条件 | 法規備考 | ||
| 抗原種 | Feline | 免疫動物 | Mouse |
| 交差性 | Feline | 適用 | ELISA |
| 標識 | Biotin | 性状 | Protein A/G Affinity Purified |
| 吸収処理 | クラス | IgG | |
| クロナリティ | Monoclonal | フォーマット | |
| 掲載カタログ |
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| 製品記事 |
M1/M2 Macrophage Activation Marker 抗幹細胞マーカー抗体／抗造血幹細胞マーカー抗体（R&D Systems社） |
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| 関連記事 |
R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Product Details
| Species Reactivity | Feline |
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| Label | Biotin |
| Immunogen | E. coli-derived recombinant feline GM-CSFAla18-Lys144 (Met36Ile, Thr56Ala & Lys126Asn)Accession # AAC06041 |
| Source | Monoclonal Mouse IgG1 Clone # 159319 |
| Purification | Protein A or G purified from hybridoma culture supernatant |
| Specificity | Detects feline GM-CSF in ELISAs. In sandwich immunoassays, no cross-reactivity or interference with recombinant porcine, human, mouse, or rat GM-CSF was observed. |
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Applications and Data
| Recommended Concentration | Sample | |
| Feline GM-CSF Sandwich Immunoassay | Reagent | |
| ELISA Capture (Matched Antibody Pair) | 2-8 µg/mL | Feline GM‑CSF Antibody (Catalog #MAB9872 ) |
| ELISA Detection (Matched Antibody Pair) | 0.5-2.0 µg/mL | Feline GM‑CSF Biotinylated Antibody (Catalog #BAM9873 ) |
| ELISA Standard | Recombinant Feline GM-CSF Protein (Catalog #987-FL ) | |
| Please Note: Optimal dilutions should be determined by each laboratory for each application.General Protocolsare available in the Technical Information section on our website. | Preparation and Storage | |
| Reconstitution | Reconstitute at 0.5 mg/mL in sterile PBS. | Reconstitution Buffer Available |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. | |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. | |
| 1 month, 2 to 8 °C under sterile conditions after reconstitution. | ||
| 6 months, -20 to -70 °C under sterile conditions after reconstitution. | ||
| Background: GM-CSF | GM-CSF was initially characterized as a factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. It is also a growth factor for erythroid, megakaryocyte, and eosinophil progenitors. GM-CSF is produced by a number of different cell types (including T cells, B cells, macrophages, mast cells, endothelial cells, fibroblasts, and adipocytes) in response to cytokine or inflammatory stimuli. On mature hematopoietic cells, GM-CSF is a survival factor for and activates the effector functions of granulocytes, monocytes/macrophages, and eosinophils (1, 2). GM-CSF promotes a Th1 biased immune response, angiogenesis, allergic inflammation, and the development of autoimmunity (3‑5). It shows clinical effectiveness in ameliorating chemotherapy-induced neutropenia, and GM-CSF transfected tumor cells are utilized as cancer vaccines (6, 7). The 22 kDa glycosylated GM-CSF, similar to IL-3 and IL-5, is a cytokine with a core of four bundled alpha ‑helices (8‑10). Mature feline GM-CSF shares 52%‑56% amino acid sequence identity with mouse and rat GM-CSF and 67%‑72% canine, human, and porcine GM‑CSF. GM-CSF exerts its biological effects through a heterodimeric receptor complex composed of GM-CSF R alpha /CD116 and the signal transducing common beta chain (CD131) which is also a component of the high-affinity receptors for IL-3 and IL-5 (11, 12). In addition, GM-CSF binds a naturally occurring soluble form of GM-CSF R alpha (13). Feline and human GM-CSF show cross-species activity (14, 15). |
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References
| Martinez-Moczygemba, M. and D.P. Huston (2003) J. Allergy Clin. Immunol. 112:653. | |
| Barreda, D.R. et al. (2004) Dev. Comp. Immunol. 28:509. | |
| Eksioglu, E.A. et al. (2007) Exp. Hematol. 35:1163. | |
| Cao, Y. (2007) J. Clin. Invest. 117:2362. | |
| Fleetwood, A.J. et al. (2005) Crit. Rev. Immunol. 25:405. | |
| Heuser, M. et al. (2007) Semin. Hematol. 44:148. | |
| Hege, K.M. et al. (2006) Int. Rev. Immunol. 25:321. | |
| Kaushansky, K. et al. (1992) Biochemistry 31:1881. | |
| Diederichs, K. et al. (1991) Science 254:1779. | |
| Dunham, S.P. and J. Bruce (2004) Gene 332:97. | |
| Onetto-Pothier, N. et al. (1990) Blood 75:59. | |
| Hayashida, K. et al. (1990) Proc. Natl. Acad. Sci. 87:9655. | |
| Pelley, J.L. et al. (2007) Exp. Hematol. 35:1483. | |
| Sprague, W.S. et al. (2005) J. Comp. Pathol. 133:136. | |
| Dunham, S.P. and J. Bruce (2004) Gene 332:97. | |
| Long Name: | Granulocyte Macrophage Growth Factor |
| Entrez Gene IDs: | 1437 (Human); 12981 (Mouse); 116630 (Rat); 397208 (Porcine); 403923 (Canine); 493805 (Feline) |
| Alternate Names: | colony stimulating factor 2 (granulocyte-macrophage); Colony-stimulating factor; CSF; CSF2; GMCSF; GM-CSF; GMCSFgranulocyte-macrophage colony-stimulating factor; granulocyte-macrophage colony stimulating factor; MGC131935; MGC138897; molgramostin; sargramostim |
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Related Research Areas
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Related Product & Information
| Background | GM-CSF |
|---|---|
| background_content | Background: GM-CSF GM-CSF was initially characterized as a factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. It is also a growth factor for erythroid, megakaryocyte, and eosinophil progenitors. GM-CSF is produced by a number of different cell types (including T cells, B cells, macrophages, mast cells, endothelial cells, fibroblasts, and adipocytes) in response to cytokine or inflammatory stimuli. On mature hematopoietic cells, GM-CSF is a survival factor for and activates the effector functions of granulocytes, monocytes/macrophages, and eosinophils (1, 2). GM-CSF promotes a Th1 biased immune response, angiogenesis, allergic inflammation, and the development of autoimmunity (3‑5). It shows clinical effectiveness in ameliorating chemotherapy-induced neutropenia, and GM-CSF transfected tumor cells are utilized as cancer vaccines (6, 7). The 22 kDa glycosylated GM-CSF, similar to IL-3 and IL-5, is a cytokine with a core of four bundled alpha ‑helices (8‑10). Mature feline GM-CSF shares 52%‑56% amino acid sequence identity with mouse and rat GM-CSF and 67%‑72% canine, human, and porcine GM‑CSF. GM-CSF exerts its biological effects through a heterodimeric receptor complex composed of GM-CSF R alpha /CD116 and the signal transducing common beta chain (CD131) which is also a component of the high-affinity receptors for IL-3 and IL-5 (11, 12). In addition, GM-CSF binds a naturally occurring soluble form of GM-CSF R alpha (13). Feline and human GM-CSF show cross-species activity (14, 15). |
追加しました。
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