抗Flt-4抗体(Anti-Flt-4, Mouse, Goat-Poly, Biotin antibody)
掲載日情報：2021/01/28 現在Webページ番号：27889
Flt-4に対する抗体(Anti-Flt-4, Mouse, Goat-Poly, Biotin )です。
※ 本製品は研究用です。研究用以外には使用できません。
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- 価格
- Product Details
- Applications and Data
- References
- Related Research Areas
- Related Product & Information
- Citations
価格
[在庫・価格 ：2025年04月26日 20時35分現在]
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Anti-Flt-4, Mouse, Goat-Poly, Biotin <Anti-VEGF Receptor 3> |
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[在庫・価格 ：2025年04月26日 20時35分現在]
Anti-Flt-4, Mouse, Goat-Poly, Biotin <Anti-VEGF Receptor 3>
文献数： 6
- 商品コード：BAF743
- メーカー：RSD
- 包装：50μg
- 価格：¥118,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | マッチドペア：Mouse VEGF R3/Flt-4 サンドイッチELISAの検出用抗体として利用可能，補足用抗体として#MAB7431，スタンダードとして#743-R3-100を用いる。 別名：EC 2.7.10 Genbank No： 2324 Protein Accession No： P35917 |
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| 法規制等 | |||
| 保存条件 | -20℃ | 法規備考 | |
| 抗原種 | Mouse | 免疫動物 | Goat |
| 交差性 | Mouse | 適用 | ELISA,FCM,Western Blot |
| 標識 | Biotin | 性状 | Antigen Affinity Purified |
| 吸収処理 | クラス | IgG | |
| クロナリティ | Polyclonal | フォーマット | |
| 掲載カタログ |
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| 製品記事 | Myeloid-derived Suppressor Cell Marker |
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| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Product Details
| Species Reactivity | Mouse |
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| Label | Biotin |
| Immunogen | S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse VEGF R3/Flt-4Tyr25-Asp770Accession # P35917 |
| Source | Polyclonal Goat IgG |
| Purification | Antigen Affinity-purified |
| Specificity | Detects mouse VEGF R3 in ELISAs and Western blots. In sandwich ELISAs, less than 7% cross-reactivity with recombinant human VEGF R3 is observed and 0.2% cross-reactivity with recombinant mouse (rm) VEGF R1 and rmVEGF R2 is observed. |
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Applications and Data
| Recommended Concentration | Sample | |
| Western Blot | 0.1 µg/mL | Recombinant Mouse VEGF R3/Flt‑4 Fc Chimera (Catalog # 743-R3) |
| Flow Cytometry | 2.5 µg/106 cells | MS‑1 mouse pancreatic islet endothelial cell line |
| Mouse VEGF R3/Flt-4 Sandwich Immunoassay | Reagent | |
| ELISA Capture (Matched Antibody Pair) | 2-8 µg/mL | Mouse VEGF R3/Flt‑4 Antibody (Catalog #MAB7431 ) |
| ELISA Detection (Matched Antibody Pair) | 0.1-0.4 µg/mL | Mouse VEGF R3/Flt‑4 Biotinylated Antibody (Catalog #BAF743 ) |
| ELISA Standard | Recombinant Mouse VEGF R3/Flt-4 Fc Chimera Protein, CF (Catalog #743-R3 ) | |
| Please Note: Optimal dilutions should be determined by each laboratory for each application.General Protocolsare available in the Technical Information section on our website. | Preparation and Storage | |
| Reconstitution | Reconstitute at 0.2 mg/mL in sterile PBS. | Reconstitution Buffer Available |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. | |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. | |
| 1 month, 2 to 8 °C under sterile conditions after reconstitution. | ||
| 6 months, -20 to -70 °C under sterile conditions after reconstitution. | ||
| Background: VEGF R3/Flt-4 | VEGF R3 (Flt-4), together with VEGF R1 (Flt-1) and VEGF R2 (KDR/Flk-1), belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domains and kinase insert domains in their intracellular regions. The expression of these receptors is almost exclusively restricted to the endothelial cells. These receptors are likely to play essential roles in vasculogenesis and angiogenesis. In adults, VEGF R3 expression is restricted to the endothelial cells of the lymphatic vessels. Mouse VEGF R3 cDNA encodes a 1363 amino acid (aa) residue precursor protein with a 24 aa residue signal peptide. Mature VEGF R3 has a 751 aa residue extracellular domain, a 22 aa residue hydrophobic transmembrane domain, and a 565 aa residue cytoplasmic domain. The polypeptide sequences of murine Flt-4 is 88% identical to the human homologue. VEGF R3 has been reported to serve as the receptors for VEGF-C and VEGF-D. |
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References
| Finnerty, H. et al. (1993) Oncogene 8:2293. | |
| Joukov, V. et al. (1996) EMBO J. 15:290. | |
| Achen, M. et al. (1998) Proc. Natl. Acad. Sci. USA 95:548. | |
| Long Name: | Vascular Endothelial Growth Factor Receptor 3 |
| Entrez Gene IDs: | 2324 (Human); 14257 (Mouse) |
| Alternate Names: | EC 2.7.10; EC 2.7.10.1; FLT4; Flt-4; fms-related tyrosine kinase 4; LMPH1A; PCLFLT41; soluble VEGFR3 variant 1; soluble VEGFR3 variant 2; soluble VEGFR3 variant 3; Tyrosine-protein kinase receptor FLT4; vascular endothelial growth factor receptor 3; VEGF R3; VEGFR3; VEGFR-3; VEGFR3Fms-like tyrosine kinase 4 |
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Related Research Areas
| Airway Inflammation and Remodeling | ||
| Endothelial Cell Markers | ||
| Endothelial Progenitor and Endothelial Cell Markers | ||
| Endothelial Progenitor Cell Markers | ||
| Receptor Tyrosine Kinases (RTKs) | ||
| Receptor Tyrosine Kinases (RTKs) in the Akt Pathway | ||
| Receptors in the Jak/STAT Pathway | ||
| VEGF Family | ||
| VEGF Receptors and Regulators on Endothelial Cells | ||
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Related Product & Information
| Background | VEGF R3/Flt-4 |
|---|---|
| background_content | Background: VEGF R3/Flt-4 VEGF R3 (Flt-4), together with VEGF R1 (Flt-1) and VEGF R2 (KDR/Flk-1), belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domains and kinase insert domains in their intracellular regions. The expression of these receptors is almost exclusively restricted to the endothelial cells. These receptors are likely to play essential roles in vasculogenesis and angiogenesis. In adults, VEGF R3 expression is restricted to the endothelial cells of the lymphatic vessels. Mouse VEGF R3 cDNA encodes a 1363 amino acid (aa) residue precursor protein with a 24 aa residue signal peptide. Mature VEGF R3 has a 751 aa residue extracellular domain, a 22 aa residue hydrophobic transmembrane domain, and a 565 aa residue cytoplasmic domain. The polypeptide sequences of murine Flt-4 is 88% identical to the human homologue. VEGF R3 has been reported to serve as the receptors for VEGF-C and VEGF-D. |
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Citations
- Mesenchymal Stromal Cells Inhibit Inflammatory Lymphangiogenesis in the Cornea by Suppressing Macrophage in a TSG-6-Dependent Manner
Authors: HB Song, SY Park, JH Ko, JW Park, CH Yoon, DH Kim, JH Kim, MK Kim, RH Lee, DJ Prockop, JY Oh
Mol. Ther., 2018;26(1):162-172.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC - Normal lymphatic development and function in mice deficient for the lymphatic hyaluronan receptor LYVE-1.
Authors: Gale NW, Prevo R, Espinosa J, Ferguson DJ, Dominguez MG, Yancopoulos GD, Thurston G, Jackson DG
Mol. Cell. Biol., 2007;27(2):595-604.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC
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