抗ST2抗体(Anti-ST2, Human, Goat-Poly, Biotin antibody)
掲載日情報：2021/01/28 現在Webページ番号：27742
ST2に対する抗体(Anti-ST2, Human, Goat-Poly, Biotin )です。
※ 本製品は研究用です。研究用以外には使用できません。
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- 価格
- Product Details
- Applications and Data
- References
- Related Research Areas
- Related Product & Information
- Citations
価格
[在庫・価格 ：2025年06月01日 00時00分現在]
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Anti-ST2/IL-33 R, Human, Goat-Poly, Biotin |
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[在庫・価格 ：2025年06月01日 00時00分現在]
Anti-ST2/IL-33 R, Human, Goat-Poly, Biotin
文献数： 1
- 商品コード：BAF523
- メーカー：RSD
- 包装：50μg
- 価格：¥118,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | マッチドペア：Human ST2/IL-1 R4 サンドイッチELISAの検出用抗体として利用可能，補足用抗体として#MAB523-500，スタンダードとして#523-ST-100を用いる。 別名：DER4 Genbank No： 9173 Protein Accession No： BAA02233 |
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| 法規制等 | |||
| 保存条件 | -20℃ | 法規備考 | |
| 抗原種 | Human | 免疫動物 | Goat |
| 交差性 | Human | 適用 | ELISA,Western Blot |
| 標識 | Biotin | 性状 | Antigen Affinity Purified |
| 吸収処理 | クラス | IgG | |
| クロナリティ | Polyclonal | フォーマット | |
| 掲載カタログ |
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| 製品記事 | Helper T Cells Marker Antibodies |
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| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Product Details
| Species Reactivity | Human, Primate |
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| Label | Biotin |
| Immunogen | S. frugiperda insect ovarian cell line Sf 21-derived recombinant human ST2/IL-33 RLys19-Phe328Accession # BAA02233 |
| Source | Polyclonal Goat IgG |
| Purification | Antigen Affinity-purified |
| Specificity | Detects human ST2/IL-33 R in ELISAs and Western blots. In sandwich immunoassays, less than 0.5% cross-reactivity with recombinant mouse ST2 Ligand is observed and less than 0.1% cross-reactivity with recombinant human (rh) IL-1 RI and rhIL-1 RII is observed. |
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Applications and Data
| Recommended Concentration | Sample | |
| Western Blot | 0.1 µg/mL | Recombinant Human ST2/IL-33 R Fc Chimera (Catalog # 523-ST) |
| Human/Primate ST2/IL-33 R Sandwich Immunoassay | Reagent | |
| ELISA Capture (Matched Antibody Pair) | 2-8 µg/mL | Human/Primate ST2/IL-33 R Antibody (Catalog #MAB523 ) |
| ELISA Detection (Matched Antibody Pair) | 0.1-0.4 µg/mL | Human/Primate ST2/IL-33 R Biotinylated Antibody (Catalog #BAF523 ) |
| ELISA Standard | Recombinant Human ST2/IL-33 R Fc Chimera Protein, CF (Catalog #523-ST ) | |
| Please Note: Optimal dilutions should be determined by each laboratory for each application.General Protocolsare available in the Technical Information section on our website. | Preparation and Storage | |
| Reconstitution | Reconstitute at 0.2 mg/mL in sterile PBS. | Reconstitution Buffer Available |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. | |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. | |
| 1 month, 2 to 8 °C under sterile conditions after reconstitution. | ||
| 6 months, -20 to -70 °C under sterile conditions after reconstitution. | ||
| Background: ST2/IL-33 R | ST2, also known as IL-1 R4 and T1, is an Interleukin-1 receptor family glycoprotein that contributes to Th2 immune responses (1, 2). Human ST2 consists of a 310 amino acid (aa) extracellular domain (ECD) with three Ig-like domains, a 21 aa transmembrane segment, and a 207 aa cytoplasmic domain with an intracellular TIR domain (3, 4). Alternate splicing of the 120 kDa human ST2 generates a soluble 60 kDa isoform that lacks the transmembrane and cytoplasmic regions as well as an isoform that additionally lacks the third Ig‑like domain (4). Within the ECD, human ST2 shares 68% and 64% aa sequence identity with mouse and rat ST2, respectively. ST2 is expressed on the surface of mast cells, activated Th2 cells, macrophages, and cardiac myocytes (5‑8). It binds IL-33, a cytokine that is upregulated by inflammation or mechanical strain in smooth muscle cells, airway epithelia, keratinocytes, and cardiac fibroblasts (5, 9). IL-33 binding induces the association of ST2 with IL-1R AcP, a shared signaling subunit that also associates with IL-1 RI and IL-1 R rp2 (1, 10, 11). In macrophages, ST2 interferes with signaling from IL-1 RI and TLR4 by sequestering the adaptor proteins MyD88 and Mal (7). In addition to its role in promoting mast cell and Th2 dependent inflammation, ST2 activation enhances antigen induced hypernociception and protects from atherosclerosis and cardiac hypertrophy (5, 12‑14). The soluble ST2 isoform is released by activated Th2 cells and strained cardiac myocytes and is elevated in the serum in allergic asthma (6, 8, 15). Soluble ST2 functions as a decoy receptor that blocks IL‑33’s ability to signal through transmembrane ST2 (10, 13‑15). |
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References
| Barksby, H.E. et al. (2007) Clin. Exp. Immunol. 149:217. | |
| Gadina, M. and C.A. Jefferies (2007) Science STKE 2007:pe31. | |
| Tominaga, S. et al. (1992) Biochim. Biophys. Acta 1171:215. | |
| Li, H. et al. (2000) Genomics 67:284. | |
| Schmitz, J. et al. (2005) Immunity 23:479. | |
| Lecart, S. et al. (2002) Eur. J. Immunol. 32:2979. | |
| Brint, E.K. et al. (2004) Nat. Immunol. 5:373. | |
| Weinberg, E.O. et al. (2002) Circulation 106:2961. | |
| Sanada S. et al. (2007) J. Clin. Invest. 117:1538. | |
| Palmer, G. et al. (2008) Cytokine 42:358. | |
| Chackerian, A.A. et al. (2007) J. Immunol. 179:2551. | |
| Allakhverdi, Z. et al. (2007) J. Immunol. 179:2051. | |
| Verri Jr., W.A. et al. (2008) Proc. Natl. Acad. Sci. 105:2723. | |
| Miller, A.M. et al. (2008) J. Exp. Med. 205:339. | |
| Hayakawa, H. et al. (2007) J. Biol. Chem. 282:26369. | |
| Long Name: | Interleukin 33 Receptor |
| Entrez Gene IDs: | 9173 (Human); 17082 (Mouse) |
| Alternate Names: | DER4; Fit-1; IL-1 R4; IL1R4; IL-1R4; IL-1RL1; IL-33R; Ly84; ST2; ST2L; ST2V; suppression of tumorigenicity 2; T1 |
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Related Research Areas
| Group 2 ILCs | ||
| IL-1 Family | ||
| Th2 Cells | ||
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Related Product & Information
| Background | ST2/IL-33 R |
|---|---|
| background_content | Background: ST2/IL-33 R ST2, also known as IL-1 R4 and T1, is an Interleukin-1 receptor family glycoprotein that contributes to Th2 immune responses (1, 2). Human ST2 consists of a 310 amino acid (aa) extracellular domain (ECD) with three Ig-like domains, a 21 aa transmembrane segment, and a 207 aa cytoplasmic domain with an intracellular TIR domain (3, 4). Alternate splicing of the 120 kDa human ST2 generates a soluble 60 kDa isoform that lacks the transmembrane and cytoplasmic regions as well as an isoform that additionally lacks the third Ig‑like domain (4). Within the ECD, human ST2 shares 68% and 64% aa sequence identity with mouse and rat ST2, respectively. ST2 is expressed on the surface of mast cells, activated Th2 cells, macrophages, and cardiac myocytes (5‑8). It binds IL-33, a cytokine that is upregulated by inflammation or mechanical strain in smooth muscle cells, airway epithelia, keratinocytes, and cardiac fibroblasts (5, 9). IL-33 binding induces the association of ST2 with IL-1R AcP, a shared signaling subunit that also associates with IL-1 RI and IL-1 R rp2 (1, 10, 11). In macrophages, ST2 interferes with signaling from IL-1 RI and TLR4 by sequestering the adaptor proteins MyD88 and Mal (7). In addition to its role in promoting mast cell and Th2 dependent inflammation, ST2 activation enhances antigen induced hypernociception and protects from atherosclerosis and cardiac hypertrophy (5, 12‑14). The soluble ST2 isoform is released by activated Th2 cells and strained cardiac myocytes and is elevated in the serum in allergic asthma (6, 8, 15). Soluble ST2 functions as a decoy receptor that blocks IL‑33’s ability to signal through transmembrane ST2 (10, 13‑15). |
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Citations
- A novel IL-1 family cytokine, IL-33, potently activates human eosinophils.
Authors: Cherry WB, Yoon J, Bartemes KR, Iijima K, Kita H
J. Allergy Clin. Immunol., 2008;121(6):1484-90.
Species: Human
Sample Type: Whole Cells
Application: Flow
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