抗IL-12抗体(Anti-IL-12, Mouse, Goat-Poly, Biotin antibody)
掲載日情報：2021/01/28 現在Webページ番号：27722
IL-12に対する抗体(Anti-IL-12, Mouse, Goat-Poly, Biotin )です。
※ 本製品は研究用です。研究用以外には使用できません。
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- 価格
- Product Details
- Applications and Data
- Related Research Areas
- Related Product & Information
- Citations
価格
[在庫・価格 ：2025年04月26日 20時55分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
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Anti-IL-12(p40), Mouse, Goat-Poly, Biotin |
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[在庫・価格 ：2025年04月26日 20時55分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
Anti-IL-12(p40), Mouse, Goat-Poly, Biotin
文献数： 6
- 商品コード：BAF499
- メーカー：RSD
- 包装：50μg
- 価格：¥119,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | マッチドペア：Mouse IL-12/IL-23 p40 Allele-specific サンドイッチELISAの検出用抗体として利用可能，補足用抗体として#MAB499-500，スタンダードとして#499-ML-025を用いる。Mouse IL-23 サンドイッチELISAの検出用抗体として利用可能，補足用抗体として#MAB1887，スタンダードとして#1887-ML-010を用いる。Mouse IL-12/IL-23 p40 Nonallele-specific サンドイッチELISAの検出用抗体として利用可能，補足用抗体として#MAB4991-500，スタンダードとして#499-ML-025を用いる。 別名：IL-12，IL-23 p40 Protein Accession No： P43432 |
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| 法規制等 | |||
| 保存条件 | -20℃ | 法規備考 | |
| 抗原種 | Mouse | 免疫動物 | Goat |
| 交差性 | Mouse | 適用 | ELISA,Western Blot |
| 標識 | Biotin | 性状 | Antigen Affinity Purified |
| 吸収処理 | クラス | IgG | |
| クロナリティ | Polyclonal | フォーマット | |
| 掲載カタログ |
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| 製品記事 | M1/M2 Macrophage Activation Marker Helper T Cells Marker Antibodies |
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| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Product Details
| Species Reactivity | Mouse |
|---|---|
| Label | Biotin |
| Immunogen | S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse IL‑12 p40Met23-Ser355Accession # P43432 |
| Source | Polyclonal Goat IgG |
| Purification | Antigen Affinity-purified |
| Specificity | Detects mouse IL-12 p40 in ELISAs and Western blots. In sandwich immunoassays, approximately 30% cross-reactivity with recombinant mouse IL‑12 p70 is observed. |
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Applications and Data
| Recommended Concentration | Sample | |
| Western Blot | 0.1 µg/mL | Recombinant Mouse IL‑12/IL‑23 p40 Homodimer (Catalog # 499-ML) |
| Mouse IL-12/IL-23 p40 Allele-specific Sandwich Immunoassay | Reagent | |
| ELISA Capture (Matched Antibody Pair) | 2-8 µg/mL | Mouse IL‑12/IL‑23 p40 Antibody (Catalog #MAB499 ) |
| ELISA Detection (Matched Antibody Pair) | 0.1-0.4 µg/mL | Mouse IL‑12/IL‑23 p40 Biotinylated Antibody (Catalog #BAF499 ) |
| ELISA Standard | Recombinant Mouse IL-12/IL-23 p40 Homodimer Protein (Catalog #499-ML ) | |
| Mouse IL-23 Sandwich Immunoassay | Reagent | |
| ELISA Capture (Matched Antibody Pair) | 2-8 µg/mL | Mouse IL‑23 Antibody (Catalog #MAB1887 ) |
| ELISA Detection (Matched Antibody Pair) | 0.1-0.4 µg/mL | Mouse IL‑12/IL‑23 p40 Biotinylated Antibody (Catalog #BAF499 ) |
| ELISA Standard | Recombinant Mouse IL-23 Protein (Catalog #1887-ML ) | |
| Mouse IL-12/IL-23 p40 Nonallele-specific Sandwich Immunoassay | Reagent | |
| ELISA Capture (Matched Antibody Pair) | 2-8 µg/mL | Mouse IL‑12/IL‑23 p40 Antibody (Catalog #MAB4991 ) |
| ELISA Detection (Matched Antibody Pair) | 0.1-0.4 µg/mL | Mouse IL‑12/IL‑23 p40 Biotinylated Antibody (Catalog #BAF499 ) |
| ELISA Standard | Recombinant Mouse IL-12/IL-23 p40 Homodimer Protein (Catalog #499-ML ) | |
| Please Note: Optimal dilutions should be determined by each laboratory for each application.General Protocolsare available in the Technical Information section on our website. | Preparation and Storage | |
| Reconstitution | Reconstitute at 0.2 mg/mL in sterile PBS. | Reconstitution Buffer Available |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. | |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. | |
| 1 month, 2 to 8 °C under sterile conditions after reconstitution. | ||
| 6 months, -20 to -70 °C under sterile conditions after reconstitution. | ||
| Background: IL-12/IL-23 p40 | Interleukin 12, also known as natural killer cell stimulatory factor (NKSF) or cytotoxic lymphocyte maturation factor (CLMF), is a pleiotropic cytokine originally identified in the medium of activated human B lymphoblastoid cell lines. IL-12 has multiple effects on T cells and NK cells and is a key mediator in the development of Th1 cells. IL-12 is a heterodimeric cytokine containing two disulfide-linked subunits, p35 and p40. Human and mouse IL-12 share 70% and 60% amino acid sequence identity in their p40 and p35 subunits, respectively. Although mouse IL-12 is active on human or mouse IL-12 responsive cells, human IL-12 is not active on mouse cells. The disulfide-linked mouse p40 homodimer can bind to IL-12 receptors and is an antagonist of IL-12 activities in vitro. The mouse p40 monomer is at least ten times less active than the homodimer as an IL-12 antagonist. At the present time, the existence and the physiological role of mouse p40 homodimer in vivo remains to be determined. |
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| Long Name: | Interleukin 12/Interleukin 23 p40 | |
| Entrez Gene IDs: | 3593 (Human); 16160 (Mouse); 64546 (Rat); 403976 (Canine); 493741 (Feline) | |
| Alternate Names: | CLMF2; IL12 p40; IL-12 p40; IL12B; IL-12B; NKSF2 | |
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Related Research Areas
| Cytokines and Receptors in Allergy and Asthma | ||
| Cytokines and Receptors in Angiogenesis | ||
| gamma delta T Cells | ||
| IL-12 Family | ||
| Th1 Cells | ||
| Th17 Cells | ||
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| All Products for IL-12/IL-23 p40 | ||
| IL-12/IL-23 p40 Primary Antibodies | ||
| IL-12/IL-23 p40 ELISAs | ||
| IL-12/IL-23 p40 Proteins and Enzymes | ||
| IL-12/IL-23 p40 ELISpot and FluoroSpot Kits | ||
| IL-12/IL-23 p40 cDNA Clones | ||
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Related Product & Information
| Background | IL-12/IL-23 p40 |
|---|---|
| background_content | Background: IL-12/IL-23 p40 Interleukin 12, also known as natural killer cell stimulatory factor (NKSF) or cytotoxic lymphocyte maturation factor (CLMF), is a pleiotropic cytokine originally identified in the medium of activated human B lymphoblastoid cell lines. IL-12 has multiple effects on T cells and NK cells and is a key mediator in the development of Th1 cells. IL-12 is a heterodimeric cytokine containing two disulfide-linked subunits, p35 and p40. Human and mouse IL-12 share 70% and 60% amino acid sequence identity in their p40 and p35 subunits, respectively. Although mouse IL-12 is active on human or mouse IL-12 responsive cells, human IL-12 is not active on mouse cells. The disulfide-linked mouse p40 homodimer can bind to IL-12 receptors and is an antagonist of IL-12 activities in vitro. The mouse p40 monomer is at least ten times less active than the homodimer as an IL-12 antagonist. At the present time, the existence and the physiological role of mouse p40 homodimer in vivo remains to be determined. |
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Citations
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
- A widespread sequence-specific mRNA decay pathway mediated by hnRNPs A1 and A2/B1
Genes Dev, 2016;30(9):1070-85.
Species: Human
Sample Type: Recombinant Protein
Application: WB - IL-Y, a synthetic member of the IL-12 cytokine family, suppresses the development of type 1 diabetes in NOD mice.
Authors: Flores R, Kim E, Zhou L, Yang C, Zhao J, Gambotto A, Robbins P
Eur J Immunol, 2015;45(11):3114-25.
Species: Mouse
Sample Type: Cell Culture Supernates
Application: DirELISA - Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFNgamma production.
Authors: Lemos HP, Grespan R, Vieira SM, Cunha TM, Verri WA, Fernandes KS, Souto FO, McInnes IB, Ferreira SH, Liew FY, Cunha FQ
Proc. Natl. Acad. Sci. U.S.A., 2009;106(14):5954-9.
Species: Mouse
Sample Type: Tissue Homogenates
Application: ELISA Development - Glechoma hederacea inhibits inflammatory mediator release in IFN-gamma and LPS-stimulated mouse peritoneal macrophages.
Authors: An HJ, Jeong HJ, Um JY, Kim HM, Hong SH
J Ethnopharmacol, 2006;106(3):418-24.
Species: Mouse
Sample Type: Cell Culture Supernates
Application: ELISA Development - 17beta-estradiol (E2) modulates cytokine and chemokine expression in human monocyte-derived dendritic cells.
Authors: Bengtsson AK, Ryan EJ, Giordano D, Magaletti DM, Clark EA
Blood, 2004;104(5):1404-10.
Species: Human
Sample Type: Cell Culture Supernates
Application: ELISA Development - AMD3100, a CxCR4 antagonist, attenuates allergic lung inflammation and airway hyperreactivity.
Authors: Lukacs NW, Berlin A, Schols D, Skerlj RT, Bridger GJ
Am. J. Pathol., 2002;160(4):1353-60.
Species: Mouse
Sample Type: Tissue Homogenates
Application: ELISA Development
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