抗IL-1 Receptor Antagonist抗体(Anti-IL-1 Receptor Antagonist, Mouse, Goat-Poly, Biotin antibody)
掲載日情報：2021/01/28 現在Webページ番号：27706
IL-1 Receptor Antagonistに対する抗体(Anti-IL-1 Receptor Antagonist, Mouse, Goat-Poly, Biotin )です。
※ 本製品は研究用です。研究用以外には使用できません。
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- 価格
- Product Details
- Applications and Data
- Related Research Areas
- Related Product & Information
- Citations
価格
[在庫・価格 ：2024年05月18日 00時00分現在]
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Anti-IL-1 Receptor Antagonist, Mouse, Goat-Poly, Biotin <Anti-IL-1RA> |
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[在庫・価格 ：2024年05月18日 00時00分現在]
Anti-IL-1 Receptor Antagonist, Mouse, Goat-Poly, Biotin <Anti-IL-1RA>
文献数： 5
- 商品コード：BAF480
- メーカー：RSD
- 包装：50μg
- 価格：¥113,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 |
マッチドペア：Mouse IL-1ra/IL-1F3 サンドイッチELISAの検出用抗体として利用可能，補足用抗体として#AF-480-NA，スタンダードとして#480-RM-010を用いる。 別名：DIRA Genbank No： 3557 |
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| 法規制等 | |||
| 保存条件 | -20℃ | 法規備考 | |
| 抗原種 | Mouse | 免疫動物 | Goat |
| 交差性 | Mouse | 適用 | ELISA,Western Blot |
| 標識 | Biotin | 性状 | Antigen Affinity Purified |
| 吸収処理 | クラス | IgG | |
| クロナリティ | Polyclonal | フォーマット | |
| 掲載カタログ |
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| 製品記事 |
M1/M2 Macrophage Activation Marker Helper T Cells Marker Antibodies |
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| 関連記事 |
R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Product Details
| Species Reactivity | Mouse |
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| Label | Biotin |
| Immunogen | E. coli-derived recombinant mouse IL‑1ra/IL-1F3 |
| Source | Polyclonal Goat IgG |
| Purification | Antigen Affinity-purified |
| Specificity | Detects mouse IL‑1ra/IL-1F3 in ELISAs and Western blots. In sandwich immunoassays, approximately 45% cross-reactivity with recombinant rat IL‑1ra is observed and less than 1% cross-reactivity with recombinant human IL-1ra, recombinant porcine IL-1ra, and recombinant equine IL‑1ra is observed. |
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Applications and Data
| Recommended Concentration | Sample | |
| Western Blot | 0.1 µg/mL | Recombinant Mouse IL‑1ra/IL‑1F3 (Catalog # 480-RM) |
| Mouse IL-1ra/IL-1F3 Sandwich Immunoassay | Reagent | |
| ELISA Capture (Matched Antibody Pair) | 0.2-0.8 µg/mL | Mouse IL‑1ra/IL‑1F3 Antibody (Catalog #AF-480-NA ) |
| ELISA Detection (Matched Antibody Pair) | 0.1-0.4 µg/mL | Mouse IL‑1ra/IL‑1F3 Biotinylated Antibody (Catalog #BAF480 ) |
| ELISA Standard | Recombinant Mouse IL-1ra/IL-1F3 Protein (Catalog #480-RM ) | |
| Please Note: Optimal dilutions should be determined by each laboratory for each application.General Protocolsare available in the Technical Information section on our website. | Preparation and Storage | |
| Reconstitution | Reconstitute at 0.2 mg/mL in sterile PBS. | Reconstitution Buffer Available |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. | |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. | |
| 1 month, 2 to 8 °C under sterile conditions after reconstitution. | ||
| 6 months, -20 to -70 °C under sterile conditions after reconstitution. | ||
| Background: IL-1ra/IL-1F3 | IL-1ra was originally isolated from the urine of patients with monocytic leukemia and has also been purified from adherent monocytes. The naturally-occurring, fully glycosylated form has an apparent molecular weight of about 25,000 Daltons. The protein shows 26% amino acid homology to IL-1 beta and 19% homology to IL-1 alpha. It will compete with either factor for receptor binding, but does not interact with either one. Human IL-1ra will bind to both types of IL-1 receptor (I and II) on human cells. In mouse, IL-1 RII does not bind IL-1ra. IL-1ra has been shown to block the inflammatory responses induced by IL-1 both in vitro and in vivo. Pre-clinical and clinical studies were done to test possible therapeutic applications for IL-1ra in the treatment of sepsis, rheumatoid arthritis and chronic myelogenous leukemia. |
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| Long Name: | Interleukin 1 Receptor Antagonist | |
| Entrez Gene IDs: | 3557 (Human); 16181 (Mouse); 60582 (Rat); 397499 (Porcine) | |
| Alternate Names: | DIRA; ICIL-1RA; IL1F3; IL-1F3; IL1ra; IL-1ra; IL-1ra3; IL1RN; IL-1RN; interleukin 1 receptor antagonist; IRAP; MVCD4 | |
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Related Research Areas
| Cytokine and Growth Factor Receptors on VSMC | ||
| Cytokines and Receptors in Allergy and Asthma | ||
| Cytokines and Receptors in Angiogenesis | ||
| IL-1 Family | ||
| Macrophage Activation Markers | ||
| Neuroinflammation | ||
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Related Product & Information
| Background | IL-1ra/IL-1F3 |
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| background_content | Background: IL-1ra/IL-1F3 IL-1ra was originally isolated from the urine of patients with monocytic leukemia and has also been purified from adherent monocytes. The naturally-occurring, fully glycosylated form has an apparent molecular weight of about 25,000 Daltons. The protein shows 26% amino acid homology to IL-1 beta and 19% homology to IL-1 alpha. It will compete with either factor for receptor binding, but does not interact with either one. Human IL-1ra will bind to both types of IL-1 receptor (I and II) on human cells. In mouse, IL-1 RII does not bind IL-1ra. IL-1ra has been shown to block the inflammatory responses induced by IL-1 both in vitro and in vivo. Pre-clinical and clinical studies were done to test possible therapeutic applications for IL-1ra in the treatment of sepsis, rheumatoid arthritis and chronic myelogenous leukemia. |
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Citations
- Stratification is the key: inflammatory biomarkers accurately direct immunomodulatory therapy in experimental sepsis.
Authors: Osuchowski MF, Connett J, Welch K, Granger J, Remick DG
Crit. Care Med., 2009;37(5):1567-73.
Species: Mouse
Sample Type: Plasma
Application: ELISA Development - Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality.
Authors: Osuchowski MF, Welch K, Siddiqui J, Remick DG
J. Immunol., 2006;177(3):1967-74.
Species: Mouse
Sample Type: Plasma
Application: ELISA Development - Sequential ELISA to profile multiple cytokines from small volumes.
Authors: Osuchowski MF, Siddiqui J, Copeland S, Remick DG
J. Immunol. Methods, 2005;302(1):172-81.
Species: Mouse
Sample Type: Plasma
Application: ELISA Development
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