抗IL-13抗体(Anti-IL-13, Mouse, Goat-Poly, Biotin antibody)
掲載日情報：2021/01/28 現在Webページ番号：27650
IL-13に対する抗体(Anti-IL-13, Mouse, Goat-Poly, Biotin )です。
※ 本製品は研究用です。研究用以外には使用できません。
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- 価格
- Product Details
- Applications and Data
- References
- Related Research Areas
- Related Product & Information
- Citations
価格
[在庫・価格 ：2025年05月10日 00時01分現在]
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[在庫・価格 ：2025年05月10日 00時01分現在]
Anti-IL-13, Mouse, Goat-Poly, Biotin
文献数： 29
- 商品コード：BAF413
- メーカー：RSD
- 包装：50μg
- 価格：¥119,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | マッチドペア：Mouse IL-13 サンドイッチELISAの検出用抗体として利用可能，補足用抗体として#MAB413-500，スタンダードとして#413-ML-005を用いる。 別名：ALRHMGC116789 Genbank No： 3596 Protein Accession No： P20109 |
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| 法規制等 | |||
| 保存条件 | -20℃ | 法規備考 | |
| 抗原種 | Mouse | 免疫動物 | Goat |
| 交差性 | Mouse | 適用 | ELISA,Western Blot |
| 標識 | Biotin | 性状 | Antigen Affinity Purified |
| 吸収処理 | クラス | IgG | |
| クロナリティ | Polyclonal | フォーマット | |
| 掲載カタログ |
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| 製品記事 | Helper T Cells Marker Antibodies |
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| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Product Details
| Species Reactivity | Mouse |
|---|---|
| Label | Biotin |
| Immunogen | E. coli-derived recombinant mouse IL-13 (R&D Systems, Catalog # 413-ML)Accession # P20109 |
| Source | Polyclonal Goat IgG |
| Purification | Antigen Affinity-purified |
| Specificity | Detects mouse IL-13 in ELISAs and Western blots. In sandwich immunoassays, less than 0.1% cross‑reactivity with rhIL-13 is observed. |
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Applications and Data
| Recommended Concentration | Sample | |
| Western Blot | 0.1 µg/mL | Recombinant Mouse IL‑13 (Catalog # 413-ML) |
| Mouse IL-13 Sandwich Immunoassay | Reagent | |
| ELISA Capture (Matched Antibody Pair) | 2-8 µg/mL | Mouse IL‑13 Antibody (Catalog #MAB413 ) |
| ELISA Detection (Matched Antibody Pair) | 0.1-0.4 µg/mL | Mouse IL‑13 Biotinylated Antibody (Catalog #BAF413 ) |
| ELISA Standard | Recombinant Mouse IL-13 Protein (Catalog #413-ML ) | |
| Please Note: Optimal dilutions should be determined by each laboratory for each application.General Protocolsare available in the Technical Information section on our website. | Preparation and Storage | |
| Reconstitution | Reconstitute at 0.2 mg/mL in sterile PBS. | Reconstitution Buffer Available |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. | |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. | |
| 1 month, 2 to 8 °C under sterile conditions after reconstitution. | ||
| 6 months, -20 to -70 °C under sterile conditions after reconstitution. | ||
| Background: IL-13 | IL-13 is a 17 kDa immunoregulatory cytokine that plays a key role in the pathogenesis of allergic asthma and atopy. It is secreted by Th1 and Th2 CD4+ T cells, NK cells, visceral smooth muscle cells, eosinophils, mast cells, and basophils (1 - 3). IL-13 circulates as a monomer with two internal disulfide bonds that contribute to a bundled four alpha -helix configuration (4, 5). Mature mouse IL-13 shares 57%, 75%, and 58% amino acid sequence identity with human, rat, and rhesus IL-13, respectively. Despite the low homology, it exhibits cross-species activity between human, mouse, and rat (6, 7). IL-13 has diverse activities on numerous cell types (8). On macrophages, IL-13 suppresses the production of proinflammatory cytokines and other cytotoxic substances. On B cells, IL-13 induces immunoglobulin class switching to IgE, upregulates the expression of MHC class II, CD71, CD72, and CD23, and costimulates proliferation. IL-13 upregulates IL-6 while downregulating IL-1 and TNF-alpha production by fibroblasts and endothelial cells. IL-13 binds with low affinity to IL-13 R alpha 1, triggering IL-13 R alpha 1 association with IL-4 R alpha. This high affinity receptor complex also functions as the type 2 IL-4 receptor complex (9, 10). Additionally, IL-13 binds with high affinity to IL-13 R alpha 2 which is expressed intracellularly, on the cell surface, and as a soluble molecule (11 - 14). IL-13 R alpha 2 regulates the bioavailability of both IL-13 and IL-4 and is overexpressed in glioma and several bronchial pathologies (10, 15, 16). Compared to wild type IL-13, the atopy-associated R110Q variant of IL-13 elicits increased responsiveness from eosinophils that express low levels of IL-13 R alpha 2 (17). |
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References
| Wills-Karp, M. (2004) Immunol. Rev. 202:175. | |
| Nakajima, H. and K. Takatsu (2007) Int. Arch. Allergy Immunol. 142:265. | |
| Brown, K.D. et al. (1989) J. Immunol. 142:679. | |
| Moy, F.J. et al. (2001) J. Mol. Biol. 310:219. | |
| Eisenmesser, E.Z. et al. (2001) J. Mol. Biol. 310:231. | |
| Ruetten, H. and C. Thiemermann (1997) Shock 8:409. | |
| Lakkis, F.G. et al. (1997) Biochem. Biophys. Res. Commun. 235:529. | |
| Wynn, T.A. (2003) Annu. Rev. Immunol. 21:425. | |
| Andrews, A.L. et al. (2002) J. Biol. Chem. 277:46073. | |
| Tabata, Y. et al. (2007) Curr. Allergy Asthma Rep. 7:338. | |
| Chiaramonte, M.G. et al. (2003) J. Exp. Med. 197:687. | |
| Daines, M.O. and G.K. Hershey (2002) J. Biol. Chem. 227:10387. | |
| Matsumura, M. et al. (2007) Biochem. Biophys. Res. Commun. 360:464. | |
| Tabata, Y. et al. (2007) J. Immunol. 177:7905. | |
| Andrews, A.L. et al. (2006) J. Allergy Clin. Immunol. 118:858. | |
| Joshi, B.H. et al. (2006) Vitam. Horm. 74:479. | |
| Andrews, A.-L. et al. (2007) J. Allergy Clin. Immunol. 120:91. | |
| Long Name: | Interleukin 13 |
| Entrez Gene IDs: | 3596 (Human); 16163 (Mouse); 116553 (Rat); 574325 (Primate) |
| Alternate Names: | ALRHMGC116789; BHR1interleukin-13; IL13; IL-13; IL-13MGC116788; interleukin 13; MGC116786; NC30; P600 |
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Related Research Areas
| Cytokines and Receptors in Allergy and Asthma | ||
| Cytokines and Receptors in Angiogenesis | ||
| Cytokines and Receptors in Tfh Cell Differentiation and Function | ||
| gamma delta T Cells | ||
| Group 2 ILCs | ||
| Myeloid-derived Suppressor Cells (MDSC) | ||
| Natural Killer T (NKT) Cells | ||
| T Cell Cytokine Signaling | ||
| Th2 Cells | ||
| Th22 Cells | ||
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Related Product & Information
| Background | IL-13 |
|---|---|
| background_content | Background: IL-13 IL-13 is a 17 kDa immunoregulatory cytokine that plays a key role in the pathogenesis of allergic asthma and atopy. It is secreted by Th1 and Th2 CD4+ T cells, NK cells, visceral smooth muscle cells, eosinophils, mast cells, and basophils (1 - 3). IL-13 circulates as a monomer with two internal disulfide bonds that contribute to a bundled four alpha -helix configuration (4, 5). Mature mouse IL-13 shares 57%, 75%, and 58% amino acid sequence identity with human, rat, and rhesus IL-13, respectively. Despite the low homology, it exhibits cross-species activity between human, mouse, and rat (6, 7). IL-13 has diverse activities on numerous cell types (8). On macrophages, IL-13 suppresses the production of proinflammatory cytokines and other cytotoxic substances. On B cells, IL-13 induces immunoglobulin class switching to IgE, upregulates the expression of MHC class II, CD71, CD72, and CD23, and costimulates proliferation. IL-13 upregulates IL-6 while downregulating IL-1 and TNF-alpha production by fibroblasts and endothelial cells. IL-13 binds with low affinity to IL-13 R alpha 1, triggering IL-13 R alpha 1 association with IL-4 R alpha. This high affinity receptor complex also functions as the type 2 IL-4 receptor complex (9, 10). Additionally, IL-13 binds with high affinity to IL-13 R alpha 2 which is expressed intracellularly, on the cell surface, and as a soluble molecule (11 - 14). IL-13 R alpha 2 regulates the bioavailability of both IL-13 and IL-4 and is overexpressed in glioma and several bronchial pathologies (10, 15, 16). Compared to wild type IL-13, the atopy-associated R110Q variant of IL-13 elicits increased responsiveness from eosinophils that express low levels of IL-13 R alpha 2 (17). |
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Citations
- Therapeutic reversal of food allergen sensitivity by mature retinoic acid-differentiated dendritic cell induction of LAG3(+)CD49b(-)Foxp3(-) regulatory T�cells
Authors: W Dawicki, C Li, J Town, X Zhang, JR Gordon
J. Allergy Clin. Immunol., 2017;139(5):1608-1620.e3.
Species: Mouse
Sample Type: Serum
Application: ELISA detection - Macrophage migration inhibitory factor deficiency enhances immune response to Nippostrongylus brasiliensis
Authors: SR Damle, RK Martin, JV Cross, DH Conrad
Mucosal Immunol, 2016;0(0):.
Species: Mouse
Sample Type: Cell Culture Supernates
Application: ELISA Development - RSV vaccine-enhanced disease is orchestrated by the combined actions of distinct CD4 T cell subsets.
Authors: Knudson C, Hartwig S, Meyerholz D, Varga S
PLoS Pathog, 2015;11(3):e1004757.
Species: Mouse
Sample Type: Cell Culture Supernates
Application: ELISA detection - Mast cells contribute to double-stranded RNA-induced augmentation of airway eosinophilia in a murine model of asthma.
Authors: Kan-o K, Matsunaga Y, Fukuyama S, Moriwaki A, Hirai-Kitajima H, Yokomizo T, Aritake K, Urade Y, Nakanishi Y, Inoue H, Matsumoto K
Respir Res, 2013;14(0):28.
Species: Mouse
Sample Type: Whole Cells
Application: Flow - Breast milk immune complexes are potent inducers of oral tolerance in neonates and prevent asthma development.
Authors: Mosconi E, Rekima A, Seitz-Polski B
Mucosal Immunol, 2010;3(5):461-74.
Species: Mouse
Sample Type: Cell Culture Supernates
Application: ELISA Development - Chlamydial respiratory infection during allergen sensitization drives neutrophilic allergic airways disease.
Authors: Horvat JC, Starkey MR, Kim RY, Beagley KW, Preston JA, Gibson PG, Foster PS, Hansbro PM
J. Immunol., 2010;184(8):4159-69.
Species: Mouse
Sample Type: Cell Culture Supernates
Application: ELISA Development - IL-6 is required for airway mucus production induced by inhaled fungal allergens.
Authors: Neveu WA, Allard JB, Dienz O, Wargo MJ, Ciliberto G, Whittaker LA, Rincon M
J. Immunol., 2009;183(3):1732-8.
Species: Mouse
Sample Type: Cell Culture Supernates
Application: ELISA Development - T-bet inhibits both TH2 cell-mediated eosinophil recruitment and TH17 cell-mediated neutrophil recruitment into the airways.
Authors: Fujiwara M, Hirose K, Kagami S, Takatori H, Wakashin H, Tamachi T, Watanabe N, Saito Y, Iwamoto I, Nakajima H
J. Allergy Clin. Immunol., 2007;119(3):662-70.
Species: Mouse
Sample Type: Whole Cells
Application: ICC - Loss of pro-apoptotic Bim promotes accumulation of pulmonary T lymphocytes and enhances allergen-induced goblet cell metaplasia.
Authors: Pierce J, Rir-Sima-Ah J, Estrada I, Wilder J, Strasser A, Tesfaigzi Y
Am. J. Physiol. Lung Cell Mol. Physiol., 2006;291(5):L862-70.
Species: Mouse
Sample Type: Tissue Homogenates
Application: ELISA Development - Severe sepsis exacerbates cell-mediated immunity in the lung due to an altered dendritic cell cytokine profile.
Authors: Wen H, Hogaboam CM, Gauldie J, Kunkel SL
Am. J. Pathol., 2006;168(6):1940-50.
Species: Mouse
Sample Type: Tissue Homogenates
Application: ELISA Development
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