抗IL-17抗体(Anti-IL-17, Human, Goat-Poly, Biotin antibody)
掲載日情報：2021/01/28 現在Webページ番号：27572
IL-17に対する抗体(Anti-IL-17, Human, Goat-Poly, Biotin )です。
※ 本製品は研究用です。研究用以外には使用できません。
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- 価格
- Product Details
- Applications and Data
- References
- Related Research Areas
- Summary
- Related Product & Information
- Citations
価格
[在庫・価格 ：2025年04月26日 20時35分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
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Anti-IL-17, Human, Goat-Poly, Biotin |
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[在庫・価格 ：2025年04月26日 20時35分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
Anti-IL-17, Human, Goat-Poly, Biotin
文献数： 15
- 商品コード：BAF317
- メーカー：RSD
- 包装：50μg
- 価格：¥120,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | マッチドペア：Human/Primate IL-17 サンドイッチELISAの検出用抗体として利用可能，補足用抗体として#MAB317-500，スタンダードとして#317-ILB-050を用いる。 別名：CTLA-8 Genbank No： 3605 Protein Accession No： Q16552 |
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| 法規制等 | |||
| 保存条件 | -20℃ | 法規備考 | |
| 抗原種 | Human | 免疫動物 | Goat |
| 交差性 | Human | 適用 | ELISA,IHC |
| 標識 | Biotin | 性状 | Antigen Affinity Purified |
| 吸収処理 | クラス | IgG | |
| クロナリティ | Polyclonal | フォーマット | |
| 掲載カタログ |
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| 製品記事 | 免疫染色システム ImmPRESS® Reagent Anti-Goat IgG M1/M2 Macrophage Activation Marker |
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| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Product Details
| Species Reactivity | Human, Primate |
|---|---|
| Label | Biotin |
| Immunogen | E. coli-derived recombinant human IL-17Ile20-Ala155Accession # Q16552 |
| Source | Polyclonal Goat IgG |
| Purification | Antigen Affinity-purified |
| Specificity | Detects human and primate IL-17 in direct ELISAs. In sandwich immunoassays, approximately 22% cross-reactivity with rhIL-17A/F heterodimer is observed, and less than 0.05% cross‑reactivity with recombinant mouse (rm) IL‑17, recombinant human (rh) IL-10, rhIL-12, rhIL-16, rhIFN-gamma, rhIL-17B, rhIL-17C, rhIL-17D, rhIL-17E and rhIL-17F is observed. |
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Applications and Data
| Recommended Concentration | Sample | |
| Human/Primate IL-17 Sandwich Immunoassay | Reagent | |
| ELISA Capture (Matched Antibody Pair) | 2-8 µg/mL | Human/Primate IL‑17/IL‑17A Antibody (Catalog #MAB317 ) |
| ELISA Detection (Matched Antibody Pair) | 0.1-0.4 µg/mL | Human/Primate IL‑17/IL‑17A Biotinylated Antibody (Catalog #BAF317 ) |
| ELISA Standard | Recombinant Human IL-17A Protein, CF (Catalog #317-ILB ) | |
| Please Note: Optimal dilutions should be determined by each laboratory for each application.General Protocolsare available in the Technical Information section on our website. | Preparation and Storage | |
| Reconstitution | Reconstitute at 0.2 mg/mL in sterile PBS. | Reconstitution Buffer Available |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. | |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. | |
| 1 month, 2 to 8 °C under sterile conditions after reconstitution. | ||
| 6 months, -20 to -70 °C under sterile conditions after reconstitution. | ||
| Background: IL-17/IL-17A | Interleukin 17 (also known as CTLA-8) is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpesvirus Saimiri. cDNA clones encoding IL-17 have been isolated from activated rat, mouse and human T cells. Human IL-17 cDNA encodes a 155 amino acid (aa) residue precursor protein with a 19 amino acid residue signal peptide that is cleaved to yield the 136 aa residue mature IL-17 containing one potential N-linked glycosylation site. Both recombinant and natural IL-17 have been shown to exist as disulfide-linked homodimers. At the amino acid level, human IL-17 shows 72% and 63% sequence identity with herpesvirus and rat IL-17, respectively. An IL-17 specific mouse cell surface receptor (IL-17 R) has been cloned. While the expression of IL-17 mRNA is restricted to activated T cells, the expression of mIL-17 R mRNA has been detected in virtually all cells and tissues tested. IL-17 exhibits multiple biological activities on a variety of cells including the induction of IL-6 and IL-8 production in fibroblasts, the enhancement of surface expression of ICAM-1 in fibroblasts, activation of NF-kappa B and costimulation of T cell proliferation. The non-glycosylated, E. coli-expressed rhIL-17 has been shown to be active on human as well as mouse cell lines. |
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References
| Yao, Z. et al. (1995) J. Immunol. 155:5483. | |
| Yao, Z. et al. (1995) Immunity 3:811. | |
| Rouvier, E. et al. (1993) J. Immunol. 150:5445. | |
| Long Name: | Interleukin 17 |
| Entrez Gene IDs: | 3605 (Human); 16171 (Mouse); 301289 (Rat); 481837 (Canine) |
| Alternate Names: | CTLA-8; CTLA8cytotoxic T-lymphocyte-associated serine esterase 8; Cytotoxic T-lymphocyte-associated antigen 8; IL17; IL-17; IL17A; IL-17A; IL-17Acytotoxic T-lymphocyte-associated protein 8; IL-17CTLA-8; IL17interleukin-17A; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin 17A |
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Related Research Areas
| B Cell Chemotaxis, Migration, and Adhesion | ||||||||
| Cytokines and Receptors in Tfh Cell Differentiation and Function | ||||||||
| gamma delta T Cells | ||||||||
| Helper T (Th) Cells | ||||||||
| IL-17 Family | ||||||||
| LTi Cells | ||||||||
| Macrophage Activation Markers | ||||||||
| Molecules Secreted by VSMC | ||||||||
| Multiple Sclerosis and Myelin Related Molecules | ||||||||
| Natural Killer T (NKT) Cells | ||||||||
| NCR-ILC3 | ||||||||
| Neuroinflammation | ||||||||
| T Cell Cytokine Signaling | ||||||||
| Th17 Cells | ||||||||
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| Images | Ratings | Applications | Species | Reviewed By | Date | Details | ||
|---|---|---|---|---|---|---|---|---|
| Very Good | ELISA | Human | Anonymous | 01/18/2018 | ||||
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Summary
| Application | ELISA |
| Sample Tested | Serum and Plasma |
| Species | Human |
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Related Product & Information
| Background | IL-17/IL-17A |
|---|---|
| background_content | Background: IL-17/IL-17A Interleukin 17 (also known as CTLA-8) is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpesvirus Saimiri. cDNA clones encoding IL-17 have been isolated from activated rat, mouse and human T cells. Human IL-17 cDNA encodes a 155 amino acid (aa) residue precursor protein with a 19 amino acid residue signal peptide that is cleaved to yield the 136 aa residue mature IL-17 containing one potential N-linked glycosylation site. Both recombinant and natural IL-17 have been shown to exist as disulfide-linked homodimers. At the amino acid level, human IL-17 shows 72% and 63% sequence identity with herpesvirus and rat IL-17, respectively. An IL-17 specific mouse cell surface receptor (IL-17 R) has been cloned. While the expression of IL-17 mRNA is restricted to activated T cells, the expression of mIL-17 R mRNA has been detected in virtually all cells and tissues tested. IL-17 exhibits multiple biological activities on a variety of cells including the induction of IL-6 and IL-8 production in fibroblasts, the enhancement of surface expression of ICAM-1 in fibroblasts, activation of NF-kappa B and costimulation of T cell proliferation. The non-glycosylated, E. coli-expressed rhIL-17 has been shown to be active on human as well as mouse cell lines. |
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Citations
R&D Systems personnel manually curate a database that contains references using R&D Systems products.The data collected includes not only links to publications in PubMed,but also provides information about sample types, species, and experimental conditions.
- IL-33 Attenuates Sepsis by Inhibiting IL-17 Receptor Signaling through Upregulation of SOCS3
Authors: R Lv, J Zhao, M Lei, D Xiao, Y Yu, J Xie
Cell. Physiol. Biochem., 2017;42(5):1961-1972.
Species: Human
Sample Type: Serum
Application: ELISA detection - Interleukin-10 and prostaglandin E2 have complementary but distinct suppressive effects on Toll-like receptor-mediated dendritic cell activation in ovarian carcinoma
Authors: E Brencicova, AL Jagger, HG Evans, M Georgouli, A Laios, S Attard Mon, G Mehra, J Spencer, AA Ahmed, S Raju-Kanki, LS Taams, SS Diebold
PLoS ONE, 2017;12(4):e0175712.
Species: Human
Sample Type: Cell Culture Supernates
Application: ELISA detection - Increase in circulating Th17 cells during anti-TNF therapy is associated with ultrasonographic improvement of synovitis in rheumatoid arthritis
Authors: Dobrina N Hull
Arthritis Res. Ther, 2016;18(1):303.
Species: Human
Sample Type: Cell Culture Supernates
Application: ELISA detection - IL-10 suppresses Th17 cells and promotes regulatory T cells in the CD4+ T cell population of rheumatoid arthritis patients.
Authors: Heo YJ, Joo YB, Oh HJ, Park MK, Heo YM, Cho ML, Kwok SK, Ju JH, Park KS, Cho SG, Park SH, Kim HY, Min JK
Immunol. Lett., 2010;127(2):150-6.
Species: Human
Sample Type: Cell Culture Supernates
Application: ELISA Development - Effect of serum content and diluent selection on assay sensitivity and signal intensity in multiplex bead-based immunoassays.
Authors: Pfleger C, Schloot N, ter Veld F
J. Immunol. Methods, 2007;329(1):214-8.
Species: Human
Sample Type: Serum
Application: Luminex Development - Ultrasensitive flow-based immunoassays using single-molecule counting.
Authors: Todd J, Freese B, Lu A, Held D, Morey J, Livingston R, Goix P
Clin. Chem., 2007;53(11):1990-5.
Species: Human
Sample Type: Plasma
Application: ELISA Development - Marked differences in human melanoma antigen-specific T cell responsiveness after vaccination using a functional microarray.
Authors: Chen DS, Soen Y, Stuge TB
PLoS Med., 2005;2(10):e265.
Species: Human
Sample Type: Whole Cells
Application: functional microarray - Plasma cell-like morphology of Th1-cytokine-producing cells associated with the loss of CD3 expression.
Authors: Page G, Sattler A, Kersten S, Thiel A, Radbruch A, Miossec P
Am. J. Pathol., 2004;164(2):409-17.
Species: Human
Sample Type: Whole Tissue
Application: IHC Paraffin-embedded
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