抗TGF-β Receptor Ⅱ抗体(Anti-TGF-β Receptor Ⅱ, Human, Goat-Poly, Biotin antibody)
掲載日情報:2021/01/28 現在Webページ番号:27514
TGF-β Receptor Ⅱに対する抗体(Anti-TGF-β Receptor Ⅱ, Human, Goat-Poly, Biotin )です。
※ 本製品は研究用です。研究用以外には使用できません。
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- 価格
- Product Details
- Applications and Data
- References
- Related Research Areas
- Related Product & Information
- Citations
価格
[在庫・価格 :2025年02月16日 00時00分現在]
詳細 | 商品名 |
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Anti-TGF-β Receptor II, Human, Goat-Poly, Biotin |
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[在庫・価格 :2025年02月16日 00時00分現在]
Anti-TGF-β Receptor II, Human, Goat-Poly, Biotin
文献数: 2
- 商品コード:BAF241
- メーカー:RSD
- 包装:50μg
- 価格:¥120,000
- 在庫:無(未発注)
- 納期:10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
説明文 | マッチドペア:Human TGF-β RII サンドイッチELISAの検出用抗体として利用可能,補足用抗体として#AF-241-NA,スタンダードとして#241-R2-025を用いる。 別名:AAT3 Genbank No: 7048 Protein Accession No: P37173 |
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法規制等 | |||
保存条件 | -20℃ | 法規備考 | |
抗原種 | Human | 免疫動物 | Goat |
交差性 | Human | 適用 | ELISA,Western Blot |
標識 | Biotin | 性状 | Antigen Affinity Purified |
吸収処理 | クラス | IgG | |
クロナリティ | Polyclonal | フォーマット | |
掲載カタログ |
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製品記事 | Helper T Cells Marker Antibodies |
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関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Product Details
Species Reactivity | Human |
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Label | Biotin |
Immunogen | Mouse myeloma cell line NS0-derived recombinant human TGF‑ beta RIIIle24-Asp159Accession # P37173 |
Source | Polyclonal Goat IgG |
Purification | Antigen Affinity-purified |
Specificity | Detects human TGF-beta RII in ELISAs and Western blots. In sandwich immunoassays, approximately 25% cross-reactivity with recombinant human (rh) TGF-beta RIIb is observed and less than 0.05% cross-reactivity with rhTGF-beta RI, rhTGF-beta RIII, recombinant mouse TGF-beta RII, and rhTGF-beta 1 is observed. |
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Applications and Data
Recommended Concentration | Sample | |
Western Blot | 0.1 µg/mL | Recombinant Human TGF-beta RII (Catalog # 241-R2) |
Human TGF-beta RII Sandwich Immunoassay | Reagent | |
ELISA Capture (Matched Antibody Pair) | 0.2-0.8 µg/mL | Human TGF‑ beta RII Antibody (Catalog #AF-241-NA ) |
ELISA Detection (Matched Antibody Pair) | 0.1-0.4 µg/mL | Human TGF‑ beta RII Biotinylated Antibody (Catalog #BAF241 ) |
ELISA Standard | Recombinant Human TGF-beta RII Protein (Catalog #241-R2 ) | |
Please Note: Optimal dilutions should be determined by each laboratory for each application.General Protocolsare available in the Technical Information section on our website. | Preparation and Storage | |
Reconstitution | Reconstitute at 0.2 mg/mL in sterile PBS. | Reconstitution Buffer Available |
Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. | |
Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. | |
1 month, 2 to 8 °C under sterile conditions after reconstitution. | ||
6 months, -20 to -70 °C under sterile conditions after reconstitution. | ||
Background: TGF-beta RII | Most cell types express three sizes of receptors for TGF-beta. These are designated type I (53 kDa), type II (70 - 85 kDa), and type III (250 - 350 kDa). The type III receptor, a proteoglycan that exists in membrane-bound and soluble forms, binds TGF-beta 1, TGF-beta 2, and TGF-beta 3 but does not appear to be involved in signal transduction. The type II receptor is a membrane-bound serine/threonine kinase that binds TGF-beta 1 and TGF-beta 3 with high affinity and TGF-beta 2 with a much lower affinity. The type I receptor is also a membrane-bound serine/threonine kinase that apparently requires the presence of the type II receptor to bind TGF-beta. Current evidence suggests that signal transduction requires the cytoplasmic domains of both the type I and type II receptors. The recombinant soluble TGF-beta type II receptor is capable of binding TGF-beta 1, TGF-beta 3, and TGF-beta 5 with sufficient affinity to act as an inhibitor of these isoforms at high concentrations. The soluble receptor also binds TGF-beta 2, but with an affinity at least two orders of magnitude lower. Binding of TGF-beta 1, TGF-beta 3, and TGF-beta 5 to the soluble TGF-beta type II receptor can also be demonstrated by using the soluble receptor as a capture agent on ELISA plates and this observation has been used as the basis for the development of immunoassays for these isoforms of TGF-beta. |
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References
Miyazono, K. et al. (1994) Adv. in Immunol. 55:181. | |
Long Name: | Transforming Growth Factor beta Receptor II |
Entrez Gene IDs: | 7048 (Human); 21813 (Mouse) |
Alternate Names: | AAT3; EC 2.7.11; EC 2.7.11.30; FAA3; HNPCC6; LDS1B; LDS2B; MFS2; RIIC; TAAD2; tbetaR-II; TGF-beta receptor type II; TGF-beta receptor type IIB; TGF-beta receptor type-2; TGF-beta RII; TGF-beta type II receptor; TGFbetaRII; TGFbeta-RII; TGFBR2; TGF-bRII; TGFR-2; transforming growth factor beta receptor type IIC; transforming growth factor, beta receptor II (70/80kDa) isoform 1; transforming growth factor, beta receptor II (70/80kDa) isoform 2; transforming growth factor, beta receptor II (70/80kDa); transforming growth factor, beta receptor II (70-80kD); Transforming growth factor-beta receptor type II |
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Related Research Areas
Airway Inflammation and Remodeling | ||
Cytokine and Growth Factor Receptors on VSMC | ||
Cytokines and Receptors in Angiogenesis | ||
Preeclampsia | ||
Regulatory T Cells (Tregs) | ||
T Cell Cytokine Signaling | ||
TGF-beta Family | ||
TGF-beta Superfamily | ||
Th17 Cells | ||
Th22 Cells | ||
Th9 Cells | ||
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Related Product & Information
Background | TGF-beta RII |
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background_content | Background: TGF-beta RII Most cell types express three sizes of receptors for TGF-beta. These are designated type I (53 kDa), type II (70 - 85 kDa), and type III (250 - 350 kDa). The type III receptor, a proteoglycan that exists in membrane-bound and soluble forms, binds TGF-beta 1, TGF-beta 2, and TGF-beta 3 but does not appear to be involved in signal transduction. The type II receptor is a membrane-bound serine/threonine kinase that binds TGF-beta 1 and TGF-beta 3 with high affinity and TGF-beta 2 with a much lower affinity. The type I receptor is also a membrane-bound serine/threonine kinase that apparently requires the presence of the type II receptor to bind TGF-beta. Current evidence suggests that signal transduction requires the cytoplasmic domains of both the type I and type II receptors. The recombinant soluble TGF-beta type II receptor is capable of binding TGF-beta 1, TGF-beta 3, and TGF-beta 5 with sufficient affinity to act as an inhibitor of these isoforms at high concentrations. The soluble receptor also binds TGF-beta 2, but with an affinity at least two orders of magnitude lower. Binding of TGF-beta 1, TGF-beta 3, and TGF-beta 5 to the soluble TGF-beta type II receptor can also be demonstrated by using the soluble receptor as a capture agent on ELISA plates and this observation has been used as the basis for the development of immunoassays for these isoforms of TGF-beta. |
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Citations
- Ad5/48 hexon oncolytic virus expressing sTGFbetaRIIFc produces reduced hepatic and systemic toxicities and inhibits prostate cancer bone metastases.
Authors: Xu W, Zhang Z, Yang Y, Hu Z, Wang C, Morgan M, Wu Y, Hutten R, Xiao X, Stock S, Guise T, Prabhakar B, Brendler C, Seth P
Mol Ther, 2014;22(8):1504-17.
Species: Human
Sample Type: Cell Culture Supernates
Application: ELISA detection - Ig-reactive CD4+CD25+ T cells from tolerized (New Zealand Black x New Zealand White)F1 mice suppress in vitro production of antibodies to DNA.
Authors: La Cava A, Ebling FM, Hahn BH
J. Immunol., 2004;173(5):3542-8.
Species: Mouse
Sample Type: Whole Cells
Application: Flow
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