抗IL-13抗体(Anti-IL-13, Human, Goat-Poly, Biotin antibody)
掲載日情報：2021/01/28 現在Webページ番号：27489
IL-13に対する抗体(Anti-IL-13, Human, Goat-Poly, Biotin )です。
※ 本製品は研究用です。研究用以外には使用できません。
追加しました。
- 価格
- Product Details
- Applications and Data
- References
- Related Research Areas
- Related Product & Information
- Citations
価格
[在庫・価格 ：2025年05月10日 00時01分現在]
| 詳細 | 商品名 |
|
文献数 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Anti-IL-13, Human, Goat-Poly, Biotin |
|
4 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
[在庫・価格 ：2025年05月10日 00時01分現在]
Anti-IL-13, Human, Goat-Poly, Biotin
文献数： 4
- 商品コード：BAF213
- メーカー：RSD
- 包装：100μg
- 価格：¥118,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | マッチドペア：Human IL-13 サンドイッチELISAの検出用抗体として利用可能，補足用抗体として#MAB213-500，スタンダードとして#213-ILB-005を用いる。 別名：ALRHMGC116789 Genbank No： 3596 Protein Accession No： AAK53823 |
||
|---|---|---|---|
| 法規制等 | |||
| 保存条件 | -20℃ | 法規備考 | |
| 抗原種 | Human | 免疫動物 | Goat |
| 交差性 | Human | 適用 | ELISA,Western Blot |
| 標識 | Biotin | 性状 | Antigen Affinity Purified |
| 吸収処理 | クラス | IgG | |
| クロナリティ | Polyclonal | フォーマット | |
| 掲載カタログ |
|
||
| 製品記事 | Helper T Cells Marker Antibodies |
||
| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
||
追加しました。
Product Details
| Species Reactivity | Human |
|---|---|
| Label | Biotin |
| Immunogen | E. coli-derived recombinant human IL-13Gly21-Asn132Accession # AAK53823 |
| Source | Polyclonal Goat IgG |
| Purification | Antigen Affinity-purified |
| Specificity | Detects human IL-13 in ELISAs and Western blots. In sandwich immunoassays, less than 0.2% cross‑reactivity with recombinant mouse IL‑13, recombinant human (rh) IL‑13 R alpha 1, and rhIL‑13 R alpha 2 is observed. |
追加しました。
Applications and Data
| Recommended Concentration | Sample | |
| Western Blot | 0.1 µg/mL | Recombinant Human IL‑13 (Catalog # 213-ILB) |
| Human IL-13 Sandwich Immunoassay | Reagent | |
| ELISA Capture (Matched Antibody Pair) | 2-8 µg/mL | Human IL‑13 Antibody (Catalog #MAB213 ) |
| ELISA Detection (Matched Antibody Pair) | 0.1-0.4 µg/mL | Human IL‑13 Biotinylated Antibody (Catalog #BAF213 ) |
| ELISA Standard | Recombinant Human IL-13 Protein (Catalog #213-ILB ) | |
| Please Note: Optimal dilutions should be determined by each laboratory for each application.General Protocolsare available in the Technical Information section on our website. | Preparation and Storage | |
| Reconstitution | Reconstitute at 0.2 mg/mL in sterile PBS. | Reconstitution Buffer Available |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. | |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. | |
| 1 month, 2 to 8 °C under sterile conditions after reconstitution. | ||
| 6 months, -20 to -70 °C under sterile conditions after reconstitution. | ||
| Background: IL-13 | IL-13 is a 17 kDa immunoregulatory cytokine that plays a key role in the pathogenesis of allergic asthma and atopy. It is secreted by Th1 and Th2 CD4+ T cells, NK cells, visceral smooth muscle cells, eosinophils, mast cells, and basophils (1 - 3). IL-13 circulates as a monomer with two internal disulfide bonds that contribute to a bundled four alpha -helix configuration (4, 5). Mature human IL-13 shares 57%, 59%, and 94% amino acid sequence identity with mouse, rat, and rhesus IL-13, respectively. Despite the low homology, it exhibits cross-species activity between human, mouse, and rat (6, 7). IL-13 has diverse activities on numerous cell types (8). On macrophages, IL-13 suppresses the production of pro‑inflammatory cytokines and other cytotoxic substances. On B cells, IL-13 induces immunoglobulin class switching to IgE, upregulates the expression of MHC class II, CD71, CD72, and CD23, and costimulates proliferation. IL-13 upregulates IL-6 while downregulating IL-1 and TNF-alpha production by fibroblasts and endothelial cells. IL-13 binds with low affinity to IL-13 R alpha 1, triggering IL-13 R alpha 1 association with IL-4 R alpha. This high affinity receptor complex also functions as the type 2 IL-4 receptor complex (9, 10). Additionally, IL-13 binds with high affinity to IL-13 R alpha 2 which is expressed intracellularly, on the cell surface, and as a soluble molecule (11 - 14). IL-13 R alpha 2 regulates the bioavailability of both IL-13 and IL-4 and is overexpressed in glioma and several bronchial pathologies (10, 15, 16). Compared to wild type IL-13, the atopy-associated R110Q variant of IL-13 elicits increased responsiveness from eosinophils that express low levels of IL-13 R alpha 2 (17). |
|
追加しました。
References
| Wills-Karp, M. (2004) Immunol. Rev. 202:175. | |
| Nakajima H. and K. Takatsu (2007) Int. Arch. Allergy Immunol. 142:265. | |
| McKenzie, A.N. et al. (1993) Proc. Natl. Acad. Sci. 90:3735. | |
| Moy, F.J. et al. (2001) J. Mol. Biol. 310:219. | |
| Eisenmesser, E.Z. et al. (2001) J. Mol. Biol. 310:231. | |
| Ruetten, H. and C. Thiemermann (1997) Shock 8:409. | |
| Lakkis, F.G. et al. (1997) Biochem. Biophys. Res. Commun. 235:529. | |
| Wynn, T.A. (2003) Annu. Rev. Immunol. 21:425. | |
| Andrews, A.L. et al. (2002) J. Biol. Chem. 277:46073. | |
| Tabata, Y. et al. (2007) Curr. Allergy Asthma Rep. 7:338. | |
| Chiaramonte, M.G. et al. (2003) J. Exp. Med. 197:687. | |
| Daines, M.O. and G.K. Hershey (2002) J. Biol. Chem. 227:10387. | |
| Matsumura, M. et al. (2007) Biochem. Biophys. Res. Commun. 360:464. | |
| Tabata, Y. et al. (2007) J. Immunol. 177:7905. | |
| Andrews, A.L. et al. (2006) J. Allergy Clin. Immunol. 118:858. | |
| Joshi, B.H. et al. (2006) Vitam. Horm. 74:479. | |
| Andrews, A-L. et al. (2007) J. Allergy Clin. Immunol. 120:91. | |
| Long Name: | Interleukin 13 |
| Entrez Gene IDs: | 3596 (Human); 16163 (Mouse); 116553 (Rat); 574325 (Primate) |
| Alternate Names: | ALRHMGC116789; BHR1interleukin-13; IL13; IL-13; IL-13MGC116788; interleukin 13; MGC116786; NC30; P600 |
追加しました。
Related Research Areas
| Cytokines and Receptors in Allergy and Asthma | ||
| Cytokines and Receptors in Angiogenesis | ||
| Cytokines and Receptors in Tfh Cell Differentiation and Function | ||
| gamma delta T Cells | ||
| Group 2 ILCs | ||
| Myeloid-derived Suppressor Cells (MDSC) | ||
| Natural Killer T (NKT) Cells | ||
| T Cell Cytokine Signaling | ||
| Th2 Cells | ||
| Th22 Cells | ||
| ||
追加しました。
Related Product & Information
| Background | IL-13 |
|---|---|
| background_content | Background: IL-13 IL-13 is a 17 kDa immunoregulatory cytokine that plays a key role in the pathogenesis of allergic asthma and atopy. It is secreted by Th1 and Th2 CD4+ T cells, NK cells, visceral smooth muscle cells, eosinophils, mast cells, and basophils (1 - 3). IL-13 circulates as a monomer with two internal disulfide bonds that contribute to a bundled four alpha -helix configuration (4, 5). Mature human IL-13 shares 57%, 59%, and 94% amino acid sequence identity with mouse, rat, and rhesus IL-13, respectively. Despite the low homology, it exhibits cross-species activity between human, mouse, and rat (6, 7). IL-13 has diverse activities on numerous cell types (8). On macrophages, IL-13 suppresses the production of pro‑inflammatory cytokines and other cytotoxic substances. On B cells, IL-13 induces immunoglobulin class switching to IgE, upregulates the expression of MHC class II, CD71, CD72, and CD23, and costimulates proliferation. IL-13 upregulates IL-6 while downregulating IL-1 and TNF-alpha production by fibroblasts and endothelial cells. IL-13 binds with low affinity to IL-13 R alpha 1, triggering IL-13 R alpha 1 association with IL-4 R alpha. This high affinity receptor complex also functions as the type 2 IL-4 receptor complex (9, 10). Additionally, IL-13 binds with high affinity to IL-13 R alpha 2 which is expressed intracellularly, on the cell surface, and as a soluble molecule (11 - 14). IL-13 R alpha 2 regulates the bioavailability of both IL-13 and IL-4 and is overexpressed in glioma and several bronchial pathologies (10, 15, 16). Compared to wild type IL-13, the atopy-associated R110Q variant of IL-13 elicits increased responsiveness from eosinophils that express low levels of IL-13 R alpha 2 (17). |
追加しました。
Citations
- Th2 cytokine response in Major Depressive Disorder patients before treatment.
Authors: Pavon L, Kiryushko D, Novitskaya V, Sandoval-Lopez G, Eugenia Hernandez M, Soroka V, Klingelhofer J, Loria F, Estrada I, Lukanidin E, Berezin V, Perez M, Moreno J, Bock E, Avila U, Leff P, Anton B, Heinze G
J. Neuroimmunol., 2006;172(1):156-65.
Species: Human
Sample Type: Serum
Application: ELISA Development - Marked differences in human melanoma antigen-specific T cell responsiveness after vaccination using a functional microarray.
Authors: Chen DS, Soen Y, Stuge TB
PLoS Med., 2005;2(10):e265.
Species: Human
Sample Type: Whole Cells
Application: functional microarray
追加しました。
製品情報は掲載時点のものですが、価格表内の価格については随時最新のものに更新されます。お問い合わせいただくタイミングにより製品情報・価格などは変更されている場合があります。
表示価格に、消費税等は含まれていません。一部価格が予告なく変更される場合がありますので、あらかじめご了承下さい。