抗Integrin α4抗体(Anti-Integrin α4, Human, Mouse-Mono antibody)

• 価格
• Product Details
• Applications and Data
• Related Product & Information
• Citations

価格

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Product Details

Species Reactivity	Human
Label	Unconjugated
Immunogen	U937 human histiocytic lymphoma cell line
Source	Monoclonal Mouse IgG1 Clone # 2B4
Purification	Protein A or G purified from hybridoma culture supernatant
Specificity	Detects human Integrin alpha 4 subunit (Needham, L.A. et al. (1994) Cell Adhesion and Communication 2:87).

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Applications and Data

	Recommended Concentration	Sample
Adhesion Blockade	The adhesion of U937 human histiocytic lymphoma cells (5 x 104 cells/well) to immobilized recombinant human VCAM-1 (10 μg/mL, 100 µL/well) was maximally inhibited (80 - 100%) by 5 μg/mL of the antibody.

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Related Product & Information

Entrez Gene IDs	3676 (Human); 16401 (Mouse)
Background	Integrin alpha 4/CD49d
background_content	Background: Integrin alpha 4/CD49d Integrin alpha 4, also known as CD49d, is a transmembrane protein that forms heterodimers with beta 1 or beta 7 integrins. These complexes contribute to the trafficking of many hematopoietic cell types. Integrins alpha 4 beta 1 (also known as VLA-4) and alpha 4 beta 7 (LPAM-1) are receptors for fibronectin, VCAM and MAdCAM-1.

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Citations

1. Humanized mouse model of Rasmussen's encephalitis supports the immune-mediated hypothesis
   Authors: H Kebir, L Carmant, F Fontaine, K Béland, CM Bosoi, NT Sanon, JI Alvarez, S Desgent, CL Pittet, D Hébert, MJ Langlois, RM Rébillard, DK Nguyen, C Cieuta-Wal, GL Holmes, HP Goodkin, JR Mytinger, MB Connolly, A Prat, E Haddad
   J. Clin. Invest., 2018;0(0):.
   Species: Mouse
   Sample Type: In Vivo
   Application: Neut


2. Bilirubin Prevents Atherosclerotic Lesion Formation in Low-Density Lipoprotein Receptor-Deficient Mice by Inhibiting Endothelial VCAM-1 and ICAM-1 Signaling
   Authors: ME Vogel, G Idelman, ES Konaniah, SD Zucker
   J Am Heart Assoc, 2017;6(4):.
   Species: Human
   Sample Type: Whole Cells
   Application: Neut


3. Expression of versican V3 by arterial smooth muscle cells alters tumor growth factor beta (TGFbeta)-, epidermal growth factor (EGF)-, and nuclear factor kappaB (NFkappaB)-dependent signaling pathways, creating a microenvironment that resists monocyte adhesion.
   Authors: Kang I, Yoon D, Braun K, Wight T
   J Biol Chem, 2014;289(22):15393-404.
   Species: Human
   Sample Type: Whole Cells
   Application: Neut


4. CD9 may contribute to the survival of human germinal center B cells by facilitating the interaction with follicular dendritic cells.
   Authors: Yoon S, Lee I, Zhang X, Zapata M, Choi Y
   FEBS Open Bio, 2014;4(0):370-6.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


5. The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-beta1 production and FcRL4 expression.
   Authors: Jelicic K, Cimbro R, Nawaz F, Huang D, Zheng X, Yang J, Lempicki R, Pascuccio M, Van Ryk D, Schwing C, Hiatt J, Okwara N, Wei D, Roby G, David A, Hwang I, Kehrl J, Arthos J, Cicala C, Fauci A
   Nat Immunol, 2013;14(12):1256-65.
   Species: Human
   Sample Type: Whole Cells
   Application: Blocking


6. Junctional adhesion molecule (JAM)-B supports lymphocyte rolling and adhesion through interaction with alpha4beta1 integrin.
   Authors: Ludwig RJ, Hardt K, Hatting M, Bistrian R, Diehl S, Radeke HH, Podda M, Schon MP, Kaufmann R, Henschler R, Pfeilschifter JM, Santoso S, Boehncke WH
   Immunology, 2009;128(2):196-205.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Neut


7. L5, the most electronegative subfraction of plasma LDL, induces endothelial vascular cell adhesion molecule 1 and CXC chemokines, which mediate mononuclear leukocyte adhesion.
   Authors: Abe Y, Fornage M, Yang CY, Bui-Thanh NA, Wise V, Chen HH, Rangaraj G, Ballantyne CM
   Atherosclerosis, 2007;192(1):56-66.
   Species: Human
   Sample Type: Whole Cells
   Application: Neut


8. High pressure promotes monocyte adhesion to the vascular wall.
   Authors: Riou S, Mees B, Esposito B, Merval R, Vilar J, Stengel D, Ninio E, van Haperen R, de Crom R, Tedgui A, Lehoux S
   Circ. Res., 2007;100(8):1226-33.
   Species: Human
   Sample Type: Whole Cells
   Application: Neut


9. Rho family small GTPases control migration of hematopoietic progenitor cells into multicellular spheroids of bone marrow stroma cells.
   Authors: Bug G, Rossmanith T, Henschler R, Kunz-Schughart LA, Schroder B, Kampfmann M, Kreutz M, Hoelzer D, Ottmann OG
   J. Leukoc. Biol., 2002;72(4):837-45.
   Species: Human
   Sample Type: Whole Cells
   Application: ICC

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