抗Gas 6抗体(Anti-Gas 6, Mouse, Goat-Poly antibody)
掲載日情報：2021/01/28 現在Webページ番号：27416
Gas 6に対する抗体(Anti-Gas 6, Mouse, Goat-Poly )です。
※ 本製品は研究用です。研究用以外には使用できません。
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- 価格
- Product Details
- Applications and Data
- References
- Related Research Areas
- Related Product & Information
- Citations
価格
[在庫・価格 ：2026年04月23日 11時15分現在]
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Anti-Gas 6, Mouse, Goat-Poly |
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Anti-Mouse Gas6 Affinity Purified Polyclonal Ab |
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[在庫・価格 ：2026年04月23日 11時15分現在]
Anti-Gas 6, Mouse, Goat-Poly
文献数： 11
- 商品コード：AF986
- メーカー：RSD
- 包装：100μg
- 価格：¥83,000
- 在庫：1個
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | マッチドペア：Mouse Gas6 サンドイッチELISAの補足用抗体として利用可能，検出用抗体として#BAF986，スタンダードとして#986-GS-025を用いる。 別名：AXLLG Genbank No： 2621 Protein Accession No： CAA42507 |
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| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | -20℃ | 法規備考 | |||||
| 抗原種 | Mouse | 免疫動物 | Goat | ||||
| 交差性 | Mouse | 適用 | ELISA,IHC | ||||
| 標識 | Unlabeled | 性状 | Antigen Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Polyclonal | フォーマット | |||||
| 掲載カタログ |
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| 製品記事 | 免疫染色システム ImmPRESS® Reagent Anti-Goat IgG |
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| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Anti-Mouse Gas6 Affinity Purified Polyclonal Ab
文献数： 9
- 商品コード：AF986-SP
- メーカー：RSD
- 包装：25μg
- 価格：¥28,000
- 在庫：1個
- 納期：2～3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | ※受注発注品。形状：溶液または凍結乾燥 別名：AXLLG Genbank No： 2621 Protein Accession No： CAA42507 |
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| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | -20℃ | 法規備考 | |||||
| 抗原種 | 免疫動物 | Goat | |||||
| 交差性 | Mouse | 適用 | ELISA,IHC | ||||
| 標識 | Unlabeled | 性状 | Antigen Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Polyclonal | フォーマット | |||||
| 掲載カタログ |
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| 製品記事 | 免疫染色システム ImmPRESS® Reagent Anti-Goat IgG 使いっきり抗体 |
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| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Product Details
| Species Reactivity | Mouse |
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| Label | Unconjugated |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant mouse Gas6 (R&D Systems, Catalog # 986-GS)Asp115-Pro673Accession # CAA42507 |
| Source | Polyclonal Goat IgG |
| Purification | Antigen Affinity-purified |
| Specificity | Detects mouse Gas6 in ELISAs and Western blots. In sandwich immunoassays, less than 10% cross-reactivity with recombinant human Gas6 is observed and less than 1% cross-reactivity with recombinant mouse Gas1 is observed. |
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Applications and Data
| Recommended Concentration | Sample | |
| Western Blot | 0.1 µg/mL | Recombinant Mouse Gas6 (Catalog # 986-GS) |
| Mouse Gas6 Sandwich Immunoassay | Reagent | |
| ELISA Capture (Matched Antibody Pair) | 0.2-0.8 µg/mL | Mouse Gas6 Antibody (Catalog #AF986 ) |
| ELISA Detection (Matched Antibody Pair) | 0.1-0.4 µg/mL | Mouse Gas6 Biotinylated Antibody (Catalog #BAF986 ) |
| ELISA Standard | Recombinant Mouse Gas6 Protein (Catalog #986-GS ) | |
| Please Note: Optimal dilutions should be determined by each laboratory for each application.General Protocolsare available in the Technical Information section on our website. | Preparation and Storage | |
| Reconstitution | Reconstitute at 0.2 mg/mL in sterile PBS. | Reconstitution Buffer Available |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C | |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. | |
| 1 month, 2 to 8 °C under sterile conditions after reconstitution. | ||
| 6 months, -20 to -70 °C under sterile conditions after reconstitution. | ||
| Background: Gas6 | Growth arrest-specific gene 6 (Gas6) was initially characterized as a gene whose expression was up-regulated in serum starved NIH 3T3 fibroblasts and whose expression is down-regulated during growth induction. Mouse Gas6 is a 673 amino acid protein that shares 81% identity to its human homolog. Gas6 is a member of the vitamin K-dependent family of proteins that includes human protein S, a negative coregulator in the blood coagulation pathway. Gas6 and protein S share structural motifs that characterize this family: an extensively gamma -carboxylated amino terminus (Gla domain), four EGF-like repeats, and a carboxy terminus containing globular (G) domains with homology to steroid hormone-binding globulin. It is a ligand for the Axl (Ufo/Ark), Sky (Dtk/Tyro3/Rse/Brt/Tif), and Mer (Eyk) families of tyrosine kinase receptors. Gas6 binds to these receptors via tandem G domains at its C-terminus. Gas6 is ubiquitously expressed, but most abundantly in lung, intestine, bone marrow and endothelium. Gas6 has been implicated in a variety of biological processes. It serves as a mitogen for fibroblasts, endothelial cells, neural cells, vascular smooth muscle cells and several tumor-derived cell lines. In addition, Gas6 prevents apoptosis, independent of its mitogenic activity. Gas6 is capable of inducing cell adhesion and chemotaxis in specific cell types. It also supports vitamin K-independent hematopoiesis when expressed by stromal cells. Gas6 signal transduction following Axl/Sky/Mer receptor activation has been reported to occur through such diverse signaling pathways as PI3K, MAP kinase, Src, Ras and beta -catenin. |
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References
| Manfioletti, G. et al. (1993) Mol. Cell Biol. 13:4976. | |
| Goruppi, S. et al. (1996) Oncogene 12:471. | |
| Crosier, K and P. Crosier (1997) Pathology 29:131. | |
| Dormady, S. et al. (2000) Proc. Natl. Acad. Sci. USA 97:12260. | |
| Goruppi, S. et al. (2001) Mol. Cell Biol. 21:902. | |
| Long Name: | Growth-arrest-specific Protein 6 |
| Entrez Gene IDs: | 2621 (Human); 14456 (Mouse) |
| Alternate Names: | AXLLG; AXLLGAXL stimulatory factor; AXSFAXL receptor tyrosine kinase ligand; DKFZp666G247; FLJ34709; Gas6; GAS-6; growth arrest-specific 6; growth arrest-specific protein 6 |
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Related Research Areas
| Hedgehog Family | ||
| Infectious Diseases | ||
| Inflammatory Mediators | ||
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Related Product & Information
| Background | Gas6 |
|---|---|
| background_content | Background: Gas6 Growth arrest-specific gene 6 (Gas6) was initially characterized as a gene whose expression was up-regulated in serum starved NIH 3T3 fibroblasts and whose expression is down-regulated during growth induction. Mouse Gas6 is a 673 amino acid protein that shares 81% identity to its human homolog. Gas6 is a member of the vitamin K-dependent family of proteins that includes human protein S, a negative coregulator in the blood coagulation pathway. Gas6 and protein S share structural motifs that characterize this family: an extensively gamma -carboxylated amino terminus (Gla domain), four EGF-like repeats, and a carboxy terminus containing globular (G) domains with homology to steroid hormone-binding globulin. It is a ligand for the Axl (Ufo/Ark), Sky (Dtk/Tyro3/Rse/Brt/Tif), and Mer (Eyk) families of tyrosine kinase receptors. Gas6 binds to these receptors via tandem G domains at its C-terminus. Gas6 is ubiquitously expressed, but most abundantly in lung, intestine, bone marrow and endothelium. Gas6 has been implicated in a variety of biological processes. It serves as a mitogen for fibroblasts, endothelial cells, neural cells, vascular smooth muscle cells and several tumor-derived cell lines. In addition, Gas6 prevents apoptosis, independent of its mitogenic activity. Gas6 is capable of inducing cell adhesion and chemotaxis in specific cell types. It also supports vitamin K-independent hematopoiesis when expressed by stromal cells. Gas6 signal transduction following Axl/Sky/Mer receptor activation has been reported to occur through such diverse signaling pathways as PI3K, MAP kinase, Src, Ras and beta -catenin. |
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Citations
- GAS6 is a key homeostatic immunological regulator of host-commensal interactions in the oral mucosa
Authors: M Nassar, Y Tabib, T Capucha, G Mizraji, T Nir, M Pevsner-Fi, G Zilberman-, O Heyman, G Nussbaum, H Bercovier, A Wilensky, E Elinav, T Burstyn-Co, AH Hovav
Proc. Natl. Acad. Sci. U.S.A, 2017;0(0):.
Species: Mouse
Sample Type: Tissue Homogenates
Application: WB - TAM receptors regulate multiple features of microglial physiology
Authors: L Fourgeaud, PG Través, Y Tufail, H Leal-Baile, ED Lew, PG Burrola, P Callaway, A Zagórska, CV Rothlin, A Nimmerjahn, G Lemke
Nature, 2016;532(7598):240-4.
Species: Mouse
Sample Type: Tissue Homogenates
Application: WB - Mutations in pre-mRNA processing factors 3, 8, and 31 cause dysfunction of the retinal pigment epithelium.
Authors: Farkas M, Lew D, Sousa M, Bujakowska K, Chatagnon J, Bhattacharya S, Pierce E, Nandrot E
Am J Pathol, 2014;184(10):2641-52.
Species: Mouse
Sample Type: Whole Tissue
Application: IF - Diversification of TAM receptor tyrosine kinase function.
Authors: Zagorska A, Traves P, Lew E, Dransfield I, Lemke G
Nat Immunol, 2014;15(10):920-8.
Species: Mouse
Sample Type: Cell Lysates
Application: WB - Genetic dissection of TAM receptor-ligand interaction in retinal pigment epithelial cell phagocytosis.
Neuron, 2012;76(6):1123-32.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC Frozen - Complement component C1q regulates macrophage expression of Mer tyrosine kinase to promote clearance of apoptotic cells.
Authors: Galvan MD, Foreman DB, Zeng E
J. Immunol., 2012;188(8):3716-23.
Species: Mouse
Sample Type: Cell Lysates
Application: WB - Role of Gas6 in erythropoiesis and anemia in mice.
Authors: Angelillo-Scherrer A, Burnier L, Lambrechts D, Fish RJ, Tjwa M, Plaisance S, Sugamele R, DeMol M, Martinez-Soria E, Maxwell PH, Lemke G, Goff SP, Matsushima GK, Earp HS, Chanson M, Collen D, Izui S, Schapira M, Conway EM, Carmeliet P
J. Clin. Invest., 2008;118(2):583-96.
Species: Mouse
Sample Type: Cell Culture Supernates
Application: ELISA Development - A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation.
Authors: Sather S, Kenyon KD, Lefkowitz JB, Liang X, Varnum BC, Henson PM, Graham DK
Blood, 2007;109(3):1026-33.
Species: Mouse
Sample Type: Serum
Application: IP
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