抗IL-17F抗体(Anti-IL-17F, Goat-Poly antibody)
掲載日情報：2021/01/28 現在Webページ番号：26924
IL-17Fに対する抗体(Anti-IL-17F, Goat-Poly )です。
※ 本製品は研究用です。研究用以外には使用できません。
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- 価格
- Product Details
- Applications and Data
- References
- Related Research Areas
- Summary
- Related Product & Information
- Citations
価格
[在庫・価格 ：2025年04月26日 20時55分現在]
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Anti-IL-17F, Goat-Poly |
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Anti-Human IL-17F Affinity Purified Polyclonal Ab |
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[在庫・価格 ：2025年04月26日 20時55分現在]
Anti-IL-17F, Goat-Poly
文献数： 7
- 商品コード：AF1335
- メーカー：RSD
- 包装：100μg
- 価格：¥107,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | マッチドペア：Human IL-17F サンドイッチELISAの補足用抗体として利用可能，検出用抗体として#BAF1335，スタンダードとして#1335-IL-025を用いる。 別名：Cytokine ML-1 Genbank No： 112744 Protein Accession No： AAK83350 |
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| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | -20℃ | 法規備考 | |||||
| 抗原種 | Human | 免疫動物 | Goat | ||||
| 交差性 | Human | 適用 | ELISA,IC,IHC,Western Blot | ||||
| 標識 | Unlabeled | 性状 | Antigen Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Polyclonal | フォーマット | |||||
| 掲載カタログ |
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| 製品記事 | 免疫染色システム ImmPRESS® Reagent Anti-Goat IgG |
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| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Anti-Human IL-17F Affinity Purified Polyclonal Ab
文献数： 0
- 商品コード：AF1335-SP
- メーカー：RSD
- 包装：25μg
- 価格：¥30,000
- 在庫：無(未発注)
- 納期：2～3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | ※受注発注品。形状：溶液または凍結乾燥 別名：Cytokine ML-1 Genbank No： 112744 Protein Accession No： AAK83350 |
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| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | -20℃ | 法規備考 | |||||
| 抗原種 | 免疫動物 | Goat | |||||
| 交差性 | Human | 適用 | ELISA,IC,IHC,Western Blot | ||||
| 標識 | Unlabeled | 性状 | Antigen Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Polyclonal | フォーマット | |||||
| 掲載カタログ |
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| 製品記事 | 免疫染色システム ImmPRESS® Reagent Anti-Goat IgG 使いっきり抗体 |
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| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Product Details
| Species Reactivity | Human, Primate |
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| Label | Unconjugated |
| Immunogen | E. coli-derived recombinant human IL-17F (R&D Systems, Catalog # 1335-IL)Arg31-Gln163Accession # AAK83350 |
| Source | Polyclonal Goat IgG |
| Purification | Antigen Affinity-purified |
| Specificity | Detects human IL-17F in ELISAs and Western blots. In sandwich immunoassays, less than 1% cross-reactivity recombinant human (rh) IL‑17, rhIL‑17B, rhIL-17C, rhIL-17D, rhIL-17E, and recombinant mouse IL-17F is observed. |
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Applications and Data
| Recommended Concentration | Sample | |
| Western Blot | 0.1 µg/mL | Recombinant Human IL‑17F (Catalog # 1335-IL) |
| Immunocytochemistry | 5-15 µg/mL | Immersion fixed human peripheral blood mononuclear cells treated with PMA and ionomycin.
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| Human/Primate IL-17F Sandwich Immunoassay | Reagent | |
| ELISA Capture (Matched Antibody Pair) | 0.2-0.8 µg/mL | Human/Primate IL‑17F Antibody (Catalog #AF1335 ) |
| ELISA Detection (Matched Antibody Pair) | 0.1-0.4 µg/mL | Human/Primate IL‑17F Biotinylated Antibody (Catalog #BAF1335 ) |
| ELISA Standard | Recombinant Human IL-17F Protein (Catalog #1335-IL ) | |
| Please Note: Optimal dilutions should be determined by each laboratory for each application.General Protocolsare available in the Technical Information section on our website. | Preparation and Storage | |
| Reconstitution | Reconstitute at 0.2 mg/mL in sterile PBS. | Reconstitution Buffer Available |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C | |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. | |
| 1 month, 2 to 8 °C under sterile conditions after reconstitution. | ||
| 6 months, -20 to -70 °C under sterile conditions after reconstitution. | ||
| Background: IL-17F | The Interleukin 17 (IL-17) family proteins, comprising six members (IL-17A through IL-17F), are secreted, structurally related proteins that share a conserved cystine-knot fold near the C-terminus, but have considerable sequence divergence at the N-terminus. With the exception of IL-17B, which exists as a non-covalently linked dimer, all IL-17 family members are disulfide-linked dimers. IL-17 family proteins are pro-inflammatory cytokines that induce local cytokine production and are involved in the regulation of immune functions (1, 2). Human IL-17F cDNA encodes a 163 aa protein with a putative 30 aa signal peptide. Among IL-17 family members, IL-17F is most closely related to IL-17A (approximately 44% aa sequence homology), but shares only limited sequence homology (16 - 30%) with IL-17B, C, D and E. Human and mouse IL-17F share 55% sequence identity. IL-17F is expressed in activated CD4+ T-cells and activated monocytes. Five receptors (IL-17 RA, B, C, D and E) have been identified (5). Although the ligands for IL-17 RD and E are not known yet, it is reported that IL-17 RA binds IL-17A, and IL-17 RB binds IL-17B and IL-17E. IL-17 RC binds IL-17A and IL-17F with similarly high affinity and functions as a receptor for both IL-17A and IL-17F (5, 6). The biological activities mediated by IL-17F are similar to those of IL‑17. IL‑17F stimulates production of IL-6, IL-8, G-CSF, and regulates cartilage matrix turnover by increasing matrix release and inhibiting new matrix synthesis (4). IL‑17F also inhibits angiogenesis and induces production of IL-2, TGF-beta, and monocyte chemoattractant protein-1 in endothelial cells (3). |
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References
| Aggarwal, S. and A.L. Gurney (2002) J. Leukoc. Biol. 71:1. | |
| Moseley, T.A. et al. (2003) Cytokine & Growth Factor Rev. 14:155. | |
| Starnes, T. et al. (2001) J. Immunol. 167:4137. | |
| Shen, F. & S. L. Gaffen (2008) Cytokine 41:92. | |
| Kuestner, R.E. et al. (2007) J. Immunol. 179:5462. | |
| Long Name: | Interleukin 17F |
| Entrez Gene IDs: | 112744 (Human); 257630 (Mouse); 301291 (Rat) |
| Alternate Names: | Cytokine ML-1; IL17F; IL-17F; IL-17Finterleukin-17F; IL24; IL-24; interleukin 17F; Interleukin-24; ML-1; ML1interleukin-24 |
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Related Research Areas
| Helper T (Th) Cells | ||||||||
| IL-17 Family | ||||||||
| T Cell Cytokine Signaling | ||||||||
| Th17 Cells | ||||||||
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| Images | Ratings | Applications | Species | Reviewed By | Date | Details | ||
|---|---|---|---|---|---|---|---|---|
| Excellent | ELISA | Human | Anonymous | 01/09/2018 | ||||
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Summary
| Application | ELISA |
| Sample Tested | EDTA Plasma |
| Species | Human |
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Related Product & Information
| Background | IL-17F |
|---|---|
| background_content | Background: IL-17F The Interleukin 17 (IL-17) family proteins, comprising six members (IL-17A through IL-17F), are secreted, structurally related proteins that share a conserved cystine-knot fold near the C-terminus, but have considerable sequence divergence at the N-terminus. With the exception of IL-17B, which exists as a non-covalently linked dimer, all IL-17 family members are disulfide-linked dimers. IL-17 family proteins are pro-inflammatory cytokines that induce local cytokine production and are involved in the regulation of immune functions (1, 2). Human IL-17F cDNA encodes a 163 aa protein with a putative 30 aa signal peptide. Among IL-17 family members, IL-17F is most closely related to IL-17A (approximately 44% aa sequence homology), but shares only limited sequence homology (16 - 30%) with IL-17B, C, D and E. Human and mouse IL-17F share 55% sequence identity. IL-17F is expressed in activated CD4+ T-cells and activated monocytes. Five receptors (IL-17 RA, B, C, D and E) have been identified (5). Although the ligands for IL-17 RD and E are not known yet, it is reported that IL-17 RA binds IL-17A, and IL-17 RB binds IL-17B and IL-17E. IL-17 RC binds IL-17A and IL-17F with similarly high affinity and functions as a receptor for both IL-17A and IL-17F (5, 6). The biological activities mediated by IL-17F are similar to those of IL‑17. IL‑17F stimulates production of IL-6, IL-8, G-CSF, and regulates cartilage matrix turnover by increasing matrix release and inhibiting new matrix synthesis (4). IL‑17F also inhibits angiogenesis and induces production of IL-2, TGF-beta, and monocyte chemoattractant protein-1 in endothelial cells (3). |
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Citations
- Upregulation of IL-17A/F from human lung tissue explants with cigarette smoke exposure: implications for COPD.
Authors: Chang Y, Al-Alwan L, Alshakfa S, Audusseau S, Mogas A, Chouiali F, Nair P, Baglole C, Hamid Q, Eidelman D
Respir Res, 2014;15(1):145.
Species: Human
Sample Type: Whole Tissue
Application: IHC Paraffin-embedded - Expression of the T helper 17-associated cytokines IL-17A and IL-17F in asthma and COPD.
Authors: Doe C, Bafadhel M, Siddiqui S, Desai D, Mistry V, Rugman P, McCormick M, Woods J, May R, Sleeman MA, Anderson IK, Brightling CE
Chest, 2011;138(5):1140-7.
Species: Human
Sample Type: Whole Tissue
Application: IHC - Tripeptidyl-peptidase II controls DNA damage responses and in vivo gamma-irradiation resistance of tumors.
Authors: Hong X, Lei L, Kunert B, Naredla R, Applequist SE, Grandien A, Glas R
Cancer Res., 2007;67(15):7165-74.
Species: Mouse
Sample Type: Cell Lysates
Application: WB
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