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IL-4 Protein 組換え体(リコンビナント)タンパク質 | Recombinant Human IL-4 Protein

掲載日情報：2018/02/07 現在Webページ番号：215978

アールアンドディー システムズ /
R&D Systems, Inc.
[メーカー略称：RSD]

R&D Systems社製の高品質なIL-4 Proteinの組換え体タンパク質(Recombinant Human IL-4 Protein)です。
※本製品は研究用です。研究用以外には使用できません。

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Recombinant Human IL-4 Protein
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説明文
純度：>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.，由来動物：Human，M.W.：15 kDa，Genbank：3565，エンドトキシンレベル：<0.10 EU per 1 µg of the protein by the LAL method.，産生：E. coli
別名：B cell growth factor 1
Genbank No： 3565
Protein Accession No： P05112
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保存条件 -20℃ 法規備考
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製品記事 抗幹細胞マーカー抗体／抗造血幹細胞マーカー抗体（R&D Systems社）
Helper T Cells Marker Antibodies
関連記事 R&D Systems 製品WHO Unit Conversion Table

[在庫・価格 ：2025年12月14日 00時00分現在]

※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。

Recombinant Human IL-4 Protein

文献数： 0

説明文 純度：>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.，由来動物：Human，M.W.：15 kDa，Genbank：3565，エンドトキシンレベル：<0.10 EU per 1 µg of the protein by the LAL method.，産生：E. coli
別名：B cell growth factor 1
Genbank No： 3565
Protein Accession No： P05112
法規制等
保存条件 -20℃ 法規備考
掲載カタログ

製品記事 抗幹細胞マーカー抗体／抗造血幹細胞マーカー抗体（R&D Systems社）
Helper T Cells Marker Antibodies
関連記事 R&D Systems 製品WHO Unit Conversion Table
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  • お問い合わせ

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CF(Carrier-Free)とは？

R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。

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Product Details

Source
E. coli-derivedHis25-Ser153, with an N-terminal Met
Accession #
P05112
Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Predicted Molecular Mass
15 kDa
SDS-PAGE
14 kDa, reducing conditions
Activity
Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. Kitamura, T. et al. (1989) J. Cell Physiol. 140:323. The ED50 for this effect is 0.05-0.2 ng/mL.The specific activity of recombinant human IL-4 is approximately 2.9 x 104 IU/μg, which is calibrated against human IL-4 WHO International Standard (NIBSC code: 88/656).

Bioactivity
Recombinant Human IL-4 (Catalog # 204-IL) stimulates cell proliferation of the TF-1 human erythroleukemic cell line. The ED50 for this effect is 0.05-02 ng/mL.
SDS-PAGE
1 μg/lane of Recombinant Human IL-4 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 14 kDa.

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Related Product & Information

Entrez Gene IDs
3565 (Human); 16189 (Mouse); 287287 (Rat); 397225 (Porcine); 280824 (Bovine); 403785 (Canine); 574281 (Primate); 100302454 (Rabbit)
Background
IL-4
Interleukin-4 (IL-4), also known as B cell-stimulatory factor-1, is a monomeric, approximately 13 kDa‑18 kDa Th2 cytokine that shows pleiotropic effects during immune responses (1‑3). It is a glycosylated polypeptide that contains three intrachain disulfide bridges and adopts a bundled four alpha -helix structure (4). Human IL-4 is synthesized with a 24 aa signal sequence. Alternate splicing generates an isoform with a 16 aa internal deletion. Mature human IL-4 shares 55%, 39% and 43% aa sequence identity with bovine, mouse, and rat IL-4, respectively. Human, mouse, and rat IL-4 are species-specific in their activities (5‑7). IL-4 exerts its effects through two receptor complexes (8, 9). The type I receptor, which is expressed on hematopoietic cells, is a heterodimer of the ligand binding IL-4 R alpha and the common gamma  chain (a shared subunit of the receptors for IL-2, -7, -9, -15, and ‑21). The type II receptor on nonhematopoietic cells consists of IL-4 R alpha and IL‑13 R alpha 1. The type II receptor also transduces IL-13 mediated signals. IL-4 is primarily expressed by Th2-biased CD4+ T cells, mast cells, basophils, and eosinophils (1, 2). It promotes cell proliferation, survival, and immunoglobulin class switch to IgG4 and IgE in human B cells, acquisition of the Th2 phenotype by naïve CD4+ T cells, priming and chemotaxis of mast cells, eosinophils, and basophils, and the proliferation and activation of epithelial cells (10‑13). IL-4 plays a dominant role in the development of allergic inflammation and asthma (12, 14).

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Citations

R&D Systems personnel manually curate a database that contains references using R&D Systems products.
The data collected includes not only links to publications in PubMed,
but also provides information about sample types, species, and experimental conditions.
Soluble HLA-associated peptide from PSF1 has a cancer vaccine potency
Authors: M Yoshida, Y Ishioka, T Ozawa, H Okuyama, M Iguchi, T Ota, T Ito, M Nagira, A Morita, H Tanaka, H Naito, H Kidoya, N Takakura
Sci Rep, 2017;7(1):11137.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Cancer-derived Circulating MicroRNAs Promote Tumor Angiogenesis by Entering Dendritic Cells to Degrade Highly Complementary MicroRNAs
Authors: J Wang, H Ye, D Zhang, K Cheng, Y Hu, X Yu, L Lu, J Hu, C Zuo, B Qian, Y Yu, S Liu, G Liu, C Mao, S Liu
Theranostics, 2017;7(6):1407-1421.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation
Authors: MA Schumacher, M Hedl, C Abraham, JK Bernard, PR Lozano, JJ Hsieh, D Almohazey, EB Bucar, S Punit, PJ Dempsey, MR Frey
Cell Death Dis, 2017;8(2):e2622.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Retinoic-acid-orphan-receptor-C inhibition suppresses Th17 cells and induces thymic aberrations
Authors: C Guntermann, A Piaia, ML Hamel, D Theil, T Rubic-Schn, A Del Rio-Es, L Dong, A Billich, K Kaupmann, J Dawson, K Hoegenauer, D Orain, S Hintermann, R Stringer, DD Patel, A Doelemeyer, M Deurinck, J Schümann
JCI Insight, 2017;2(5):e91127.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination
Authors: H Zan, C Tat, Z Qiu, JR Taylor, JA Guerrero, T Shen, P Casali
Nat Commun, 2017;8(0):14244.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
The IGH locus relocalizes to a recombination compartment in the perinucleolar region of differentiating B-lymphocytes
Authors: A Pichugin, OV Iarovaia, A Gavrilov, I Sklyar, N Barinova, A Barinov, E Ivashkin, G Caron, S Aoufouchi, SV Razin, T Fest, M Lipinski, YS Vassetzky
Oncotarget, 2017;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Th1high in tumor microenvironment is an indicator of poor prognosis for patients with NSCLC
Authors: J Huang, F Shen, H Huang, C Ling, G Zhang
Oncotarget, 2017;8(8):13116-13125.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Vaccination with poly(IC:LC) and peptide-pulsed autologous dendritic cells in patients with pancreatic cancer
Authors: S Mehrotra, CD Britten, S Chin, E Garrett-Ma, CA Cloud, M Li, G Scurti, ML Salem, MH Nelson, MB Thomas, CM Paulos, AM Salazar, MI Nishimura, MP Rubinstein, Z Li, DJ Cole
J Hematol Oncol, 2017;10(1):82.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Gla-rich protein function as an anti-inflammatory agent in monocytes/macrophages: Implications for calcification-related chronic inflammatory diseases
Authors: CSB Viegas, RM Costa, L Santos, PA Videira, Z Silva, N Araújo, AL Macedo, AP Matos, C Vermeer, DC Simes
PLoS ONE, 2017;12(5):e0177829.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
A phase II trial of autologous dendritic cell vaccination and radiochemotherapy following fluorescence-guided surgery in newly diagnosed glioblastoma patients
Authors: S Inogés, S Tejada, AL de Cerio, JG Pérez-Larr, J Espinós, MA Idoate, PD Domínguez, RG de Eulate, J Aristu, M Bendandi, F Pastor, M Alonso, E Andreu, FP Cardoso, RD Valle
J Transl Med, 2017;15(1):104.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Dendritic cell MST1 inhibits Th17 differentiation
Authors: C Li, Y Bi, Y Li, H Yang, Q Yu, J Wang, Y Wang, H Su, A Jia, Y Hu, L Han, J Zhang, S Li, W Tao, G Liu
Nat Commun, 2017;8(0):14275.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Oil-Soluble Contrast Medium (OSCM) for Hysterosalpingography Modulates Dendritic Cell and Regulatory T Cell Profiles in the Peritoneal Cavity: A Possible Mechanism by Which OSCM Enhances Fertility
Authors: G Izumi, K Koga, M Takamura, W Bo, M Nagai, M Miyashita, M Harada, T Hirata, Y Hirota, O Yoshino, T Fujii, Y Osuga
J. Immunol., 2017;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Dendritic Cell Lineage Potential in Human Early Hematopoietic Progenitors
Authors: J Helft, F Anjos-Afon, AG van der Ve, P Chakravart, D Bonnet, C Reis E Sou
Cell Rep, 2017;20(3):529-537.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Characterization of tonsillar IL10 secreting B cells and their role in the pathophysiology of tonsillar hypertrophy
Authors: L Sarmiento, J De Rosa, A Machicote, LA Billordo, P Baz, PM Fernández, I Kaimen Mac, A Blanco, EI Arana
Sci Rep, 2017;7(1):11077.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
CXCL4 Exposure Potentiates TLR-Driven Polarization of Human Monocyte-Derived Dendritic Cells and Increases Stimulation of T Cells
Authors: SC Silva-Card, AJ Affandi, L Spel, M Cossu, JAG van Roon, M Boes, TRDJ Radstake
J. Immunol., 2017;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
GATA3 regulates FLG and FLG2 expression in human primary keratinocytes
Authors: J Zeitvogel, N Jokmin, S Rieker, I Klug, C Brandenber, T Werfel
Sci Rep, 2017;7(1):11847.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Colony-stimulating factor 1 receptor blockade inhibits tumor growth by altering the polarization of tumor-associated macrophages in hepatocellular carcinoma
Authors: JY Ao, XD Zhu, ZT Chai, H Cai, YY Zhang, KZ Zhang, LQ Kong, N Zhang, BG Ye, DN Ma, HC Sun
Mol. Cancer Ther., 2017;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Activated Natural Killer Cells Mediate the Suppressive Effect of Interleukin-4 on Tumor Development via STAT6 Activation in an Atopic Condition Melanoma Model
Authors: DJ Son, YY Jung, MH Park, HL Lee, MJ Song, HS Yoo, DY Hwang, SB Han, JT Hong
Neoplasia, 2017;19(7):537-548.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Differential Th17 response induced by the two clades of the pandemic ST258 Klebsiella pneumoniae clonal lineages producing KPC-type carbapenemase
Authors: AM Clemente, G Castronovo, A Antonelli, MM D'Andrea, M Tanturli, E Perissi, S Paccosi, A Parenti, F Cozzolino, GM Rossolini, MG Torcia
PLoS ONE, 2017;12(6):e0178847.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Establishment of induced pluripotent stem cells from normal B cells and inducing AID expression in their differentiation into hematopoietic progenitor cells
Authors: F Kawamura, M Inaki, A Katafuchi, Y Abe, N Tsuyama, Y Kurosu, A Yanagi, M Higuchi, S Muto, T Yamaura, H Suzuki, H Noji, S Suzuki, MA Yoshida, M Sasatani, K Kamiya, M Onodera, A Sakai
Sci Rep, 2017;7(1):1659.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
CD99 isoforms regulate CD1a expression in human monocyte-derived DCs through ATF-2/CREB-1 phosphorylation
Authors: K Mahiddine, A Mallaviall, H Bziouech, F Larbret, A Bernard, G Bernard
Eur J Immunol, 2016;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
JAK-STAT6 Pathway Inhibitors Block Eotaxin-3 Secretion by Epithelial Cells and Fibroblasts from Esophageal Eosinophilia Patients: Promising Agents to Improve Inflammation and Prevent Fibrosis in EoE
Authors: Edaire Cheng
PLoS ONE, 2016;11(6):e0157376.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Ani9, A Novel Potent Small-Molecule ANO1 Inhibitor with Negligible Effect on ANO2
PLoS ONE, 2016;11(5):e0155771.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status
Circ Res, 2016;0(0):.
Species: Human
Sample Type: Plasma
Application: Bioassay
MiR-146a modulates macrophage polarization in systemic juvenile idiopathic arthritis by targeting INHBA
Mol Immunol, 2016;77(0):205-212.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Diverse fates of uracilated HIV-1 DNA during infection of myeloid lineage cells
Elife, 2016;5(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
JAK2 Disease-Risk Variants Are Gain of Function and JAK Signaling Threshold Determines Innate Receptor-Induced Proinflammatory Cytokine Secretion in Macrophages
J Immunol, 2016;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Impaired Tight Junctions in Atopic Dermatitis Skin and in a Skin-Equivalent Model Treated with Interleukin-17
PLoS ONE, 2016;11(9):e0161759.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Procyanidin A2 Modulates IL-4-Induced CCL26 Production in Human Alveolar Epithelial Cells
Int J Mol Sci, 2016;17(11):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Thymic stromal chemokine TSLP acts through Th2 cytokine production to induce cutaneous T cell lymphoma
Cancer Res, 2016;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
CD11c/CD18 Dominates Adhesion of Human Monocytes, Macrophages and Dendritic Cells over CD11b/CD18
PLoS ONE, 2016;11(9):e0163120.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Cryptococcus gattii Capsule Blocks Surface Recognition Required for Dendritic Cell Maturation Independent of Internalization and Antigen Processing.
Authors: Huston S, Ngamskulrungroj P, Xiang R, Ogbomo H, Stack D, Li S, Timm-McCann M, Kyei S, Oykhman P, Kwon-Chung K, Mody C
J Immunol, 2016;196(3):1259-71.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Enhanced Cytotoxic CD8 T Cell Priming Using Dendritic Cell-Expressing Human Papillomavirus-16 E6/E7-p16INK4 Fusion Protein with Sequenced Anti-Programmed Death-1
Authors: TM Garcia-Bat, E Kim, F Concha-Ben, S Trivedi, RB Mailliard, A Gambotto, RL Ferris
J. Immunol, 2016;196(6):2870-8.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Posttranscriptional upregulation of p53 by reactive oxygen species in chronic lymphocytic leukemia
Cancer Res, 2016;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Adenovirally-Induced Polyfunctional T Cells Do Not Necessarily Recognize the Infected Target: Lessons from a Phase I Trial of the AERAS-402 Vaccine
Sci Rep, 2016;6(0):36355.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
An Allergic Lung Microenvironment Suppresses Carbon Nanotube-Induced Inflammasome Activation via STAT6-Dependent Inhibition of Caspase-1.
Authors: Shipkowski K, Taylor A, Thompson E, Glista-Baker E, Sayers B, Messenger Z, Bauer R, Jaspers I, Bonner J
PLoS ONE, 2015;10(6):e0128888.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
TLR8 Senses Bacterial RNA in Human Monocytes and Plays a Nonredundant Role for Recognition of Streptococcus pyogenes.
Authors: Eigenbrod T, Pelka K, Latz E, Kreikemeyer B, Dalpke A
J Immunol, 2015;195(3):1092-9.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Histamine promotes the development of monocyte-derived dendritic cells and reduces tumor growth by targeting the myeloid NADPH oxidase.
Authors: Martner A, Wiktorin H, Lenox B, Ewald Sander F, Aydin E, Aurelius J, Thoren F, Stahlberg A, Hermodsson S, Hellstrand K
J Immunol, 2015;194(10):5014-21.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Novel mechanism of macrophage-mediated metastasis revealed in a zebrafish model of tumor development.
Authors: Wang J, Cao Z, Zhang X, Nakamura M, Sun M, Hartman J, Harris R, Sun Y, Cao Y
Cancer Res, 2015;75(2):306-15.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Association of antigen-specific T-cell responses with antigen expression and immunoparalysis in multiple myeloma.
Authors: Fichtner S, Hose D, Engelhardt M, Meissner T, Neuber B, Krasniqi F, Raab M, Schonland S, Ho A, Goldschmidt H, Hundemer M
Clin Cancer Res, 2015;21(7):1712-21.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Dendritic cell SIRT1-HIF1alpha axis programs the differentiation of CD4+ T cells through IL-12 and TGF-beta1.
Authors: Liu G, Bi Y, Xue L, Zhang Y, Yang H, Chen X, Lu Y, Zhang Z, Liu H, Wang X, Wang R, Chu Y, Yang R
Proc Natl Acad Sci U S A, 2015;112(9):E957-65.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Mapping the HLA ligandome landscape of acute myeloid leukemia: a targeted approach toward peptide-based immunotherapy.
Authors: Berlin C, Kowalewski D, Schuster H, Mirza N, Walz S, Handel M, Schmid-Horch B, Salih H, Kanz L, Rammensee H, Stevanovic S, Stickel J
Leukemia, 2015;29(3):647-59.
Species: Human
Sample Type: Whole Cells
Application: Bioassay

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製品情報は掲載時点のものですが、価格表内の価格については随時最新のものに更新されます。お問い合わせいただくタイミングにより製品情報・価格などは変更されている場合があります。
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