抗Human IL-4 R alpha Allophycocyanin抗体(Anti-Human IL-4 R alpha Allophycocyanin antibody)

• 価格
• Product Details
• Applications and Data
• Related Product & Information
• Citations

価格

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Product Details

Species Reactivity	Human
Label	Allophycocyanin
Immunogen	S. frugiperda insect ovarian cell line Sf 21-derived recombinant human IL‑4 RGly24-His232Accession # P24394
Source	Monoclonal Mouse IgG2A Clone # 25463
Purification	Protein A or G purified from ascites
Specificity	Detects human IL‑4 R alpha in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human (rh) IL-9 R, recombinant mouse IL-4 R, rhIL-5 R alpha, rhIL-5 R beta, rhIL-13 R alpha 1, or rhIL-13 R alpha 2 is observed.

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Applications and Data

	Recommended Concentration	Sample
Flow Cytometry	10 µL/106 cells	See below

Flow Cytometry
	Detection of IL‑4 R alpha in Daudi Human Cell Line by Flow Cytometry. Daudi human Burkitt's lymphoma cell line was stained with Mouse Anti-Human IL‑4 R alpha APC‑conjugated Monoclonal Antibody (Catalog # FAB230A, filled histogram) or isotype control antibody (Catalog # IC003A, open histogram). View our protocol for Staining Membrane-associated Proteins.

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Related Product & Information

Long Name	Interleukin 4 Receptor alpha
Background	IL-4 R alpha
background_content	Background: IL-4 R alpha Interleukin 4 receptor (IL-4 R) is the transmembrane ligand binding subunit of the heterodimeric IL-4 receptor complex. In the type I receptor complex, IL-4 R associates with the common gamma chain, whereas in the type II receptor complex, it associates with IL-13 R alpha 1. IL-4 R is expressed by B cells, T cells, monocytes and macrophages.

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Citations

1. 4PD Functionalized Dendrimers: A Flexible Tool for In Vivo Gene Silencing of Tumor-Educated Myeloid Cells
   Authors: S Zilio, JL Vella, AC De la Fuen, PM Daftarian, DT Weed, A Kaifer, I Marigo, K Leone, V Bronte, P Serafini
   J. Immunol., 2017;0(0):.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


2. The TORC1-activated Proteins, p70S6K and GRB10, Regulate IL-4 Signaling and M2 Macrophage Polarization by Modulating Phosphorylation of Insulin Receptor Substrate-2
   Authors: Nicola M Heller
   J. Biol. Chem., 2016;291(48):24922-24930.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


3. Absence of a role for interleukin-13 in inflammatory bowel disease.
   Authors: Biancheri P, Di Sabatino A, Ammoscato F, Facciotti F, Caprioli F, Curciarello R, Hoque S, Ghanbari A, Joe-Njoku I, Giuffrida P, Rovedatti L, Geginat J, Corazza G, MacDonald T
   Eur J Immunol, 2014;44(2):370-85.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow


4. Presence of circulating Her2-reactive CD8 + T-cells is associated with lower frequencies of myeloid-derived suppressor cells and regulatory T cells, and better survival in older breast cancer patients.
   Authors: Bailur J, Gueckel B, Derhovanessian E, Pawelec G
   Breast Cancer Res, 0;17(0):34.
   Species: Human
   Sample Type: Whole Cells
   Application: Flow

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