抗BRCA2 [5F6]抗体 | Anti-BRCA2 [5F6] antibody

• 特長
• 価格
• DATA IMAGES
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET
• REFERENCEE(抜粋)

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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DATA IMAGES

Sample (30 μg of whole cell lysate) A: HeLa 5% SDS PAGE GTX70123 diluted at 1:500 The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.

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製品情報

Host	Mouse
Clonality	Monoclonal
Clone Name	5F6
Isotype	IgG1
Application	WB, IHC-P, IHC-Fr
Reactivity	Human

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APPLICATION

Application Note

Do not boil samples for longer than two minutes. For WB: Use at a concentration of 1-5 μg/ml. Predicted molecular weight: 380 kDa. Optimal dilutions/concentrations should be determined by the reseracher.

Calculated MW	390 kDa. ( Note )

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PROPERTIES

Form	Liquid
Buffer	PBS
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration	1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species	Human
Immunogen	Amino acids 2336-2478 of human BRCA2 expressed in E. coli. BRCA2-P400.
Purification	Protein G purified
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	Brca2, Dna Repair Associated , Brcc2 , Brovca2 , Facd , Fad , Fad1 , Fancd , Fancd1 , Glm3 , Pnca2 , Xrcc11 , Brca2
Cellular Localization	Nuclear
Background	BRCA2-5F6 recognizes the BRCA2 gene product, a 390kDa nuclear protein. The BRCA2 gene was originally isolated based on its importance in the predisposition of women to early-onset breast and ovarian cancers, suggesting mutations affect its tumor suppressor-like activity. Targeted disruption of the BRCA2 gene in mice and binding of Rad51 to its carboxyl terminus have indicated an involvement in DNA recombination and double strand break repair.
Database	・ Gene ID: 675 ・ UniProt: P51587

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REFERENCEE(抜粋)

Application Reference	Application/Reactivity
Bosviel R et al. OMICS 2012; 16 (5) : 235-44 Can soy phytoestrogens decrease DNA methylation in BRCA1 and BRCA2 oncosuppressor genes in breast cancer?	Application : IHC-P Reactivity : Human
Bernard-Gallon DJ et al. Anticancer Res 2004; 24 (1) : 321-4 Differential expressions of BRCA1 and BRCA2 in infantile gynecomastia.	Application : IHC-P Reactivity : Human
Bernard-Gallon DJ et al. Breast Cancer Res 2001; 3 (1) : 22402 BRCA1 and BRCA2 protein expressions in an ovotestis of a 46, XX true hermaphrodite.	Application : IHC-P Reactivity : Human

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