TNF-alpha 組換え体(リコンビナント)タンパク質 | Recombinant Rat TNF-alpha

掲載日情報:2015/01/26 現在Webページ番号:112963

R&D Systems社製の高品質なTNF-alphaの組換え体タンパク質(Recombinant Rat TNF-alpha)です。
本製品は研究用です。研究用以外には使用できません。

[在庫・価格 :2024年03月28日 19時15分現在]

※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
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納期 文献数
TNF-α, Rat, Recombinant
10日程度 ※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。 57
説明文
産生:E. coli,純度:>97%, by SDS-PAGE under reducing conditions and visualized by silver stain,由来動物:Rat,M.W.:17 kDa,Genbank:7124,エンドトキシンレベル:<0.1 EU per 1 µg of the protein by the LAL method.
別名:APC1 protein
Genbank No: 7124
Protein Accession No: P16599
別包装品 別包装品あり
法規制等
保存条件 -20℃ 法規備考
掲載カタログ

製品記事 組換え体TNF-α
抗幹細胞マーカー抗体/抗造血幹細胞マーカー抗体(R&D Systems社)
Helper T Cells Marker Antibodies
関連記事
TNF-α, Rat, Recombinant, Carrier-free
10日程度 ※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。 0
説明文
産生:E. coli,純度:>97%, by SDS-PAGE under reducing conditions and visualized by silver stain,由来動物:Rat,M.W.:17 kDa,Genbank:7124,エンドトキシンレベル:<0.1 EU per 1 µg of the protein by the LAL method.
別名:APC1 protein
Genbank No: 7124
Protein Accession No: P16599
別包装品 別包装品あり
法規制等
保存条件 -20℃ 法規備考
掲載カタログ

製品記事 組換え体TNF-α
抗幹細胞マーカー抗体/抗造血幹細胞マーカー抗体(R&D Systems社)
Helper T Cells Marker Antibodies
関連記事

[在庫・価格 :2024年03月28日 19時15分現在]

※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。

TNF-α, Rat, Recombinant

文献数: 57

説明文 産生:E. coli,純度:>97%, by SDS-PAGE under reducing conditions and visualized by silver stain,由来動物:Rat,M.W.:17 kDa,Genbank:7124,エンドトキシンレベル:<0.1 EU per 1 µg of the protein by the LAL method.
別名:APC1 protein
Genbank No: 7124
Protein Accession No: P16599
別包装品 別包装品あり
法規制等
保存条件 -20℃ 法規備考
掲載カタログ

製品記事 組換え体TNF-α
抗幹細胞マーカー抗体/抗造血幹細胞マーカー抗体(R&D Systems社)
Helper T Cells Marker Antibodies
関連記事

TNF-α, Rat, Recombinant, Carrier-free

文献数: 0

説明文 産生:E. coli,純度:>97%, by SDS-PAGE under reducing conditions and visualized by silver stain,由来動物:Rat,M.W.:17 kDa,Genbank:7124,エンドトキシンレベル:<0.1 EU per 1 µg of the protein by the LAL method.
別名:APC1 protein
Genbank No: 7124
Protein Accession No: P16599
別包装品 別包装品あり
法規制等
保存条件 -20℃ 法規備考
掲載カタログ

製品記事 組換え体TNF-α
抗幹細胞マーカー抗体/抗造血幹細胞マーカー抗体(R&D Systems社)
Helper T Cells Marker Antibodies
関連記事

バルク注文に関して

バルク包装品も承ります。お気軽にお問合せ下さい。

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CF(Carrier-Free)とは?

R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。

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Product Details

Source
E. coli-derived, Leu80-Leu235, with an N-terminal Met
Accession
P16599
Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Predicted Molecular Mass
17 kDa
Activity
Measured in a cytotoxicity assay using L‑929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D. Matthews, N. and M.L. Neale (1987) in Lymphokines and Interferons, A Practical Approach. Clemens, M.J. et al. (eds)

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Additional Information

Molecule Information
TNF-alpha
Aliases
Cachetin; DIF; TNF; tnfa; tnf-a; TNFSF1A; TNFSF2
Entrez Gene IDs
7124 (Human); 21926 (Mouse); 24835 (Rat); 397086 (Porcine); 280943 (Bovine); 403922 (Canine); 100033834 (Equine); 493755 (Feline); 100009088 (Rabbit)
Background
TNF-alpha Background
Tumor necrosis factor alpha (TNF-α), also known as cachectin and TNFSF2, is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that plays a central role in inflammation, apoptosis, and immune system development. TNF-α is produced by a wide variety of immune and epithelial cell types. Human TNF-α consists of a 35 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a 177 aa extracellular domain (ECD). Within the ECD, human TNF-α shares 97% aa sequence identity with rhesus and 71% - 92% with bovine, canine, cotton rat, equine, feline, mouse, porcine, and rat TNF-α. The 26 kDa type 2 transmembrane protein is assembled intracellularly to form a noncovalently linked homotrimer. Ligation of this complex induces reverse signaling that promotes lymphocyte costimulation but diminishes monocyte responsiveness.Cleavage of membrane bound TNF-α by TACE/ADAM17 releases a 55 kDa soluble trimeric form of TNF-α. TNF-α trimers bind the ubiquitous TNF RI and the hematopoietic cell-restricted TNF RII, both of which are also expressed as homotrimers. TNF-α regulates lymphoid tissue development through control of apoptosis. It also promotes inflammatory responses by inducing the activation of vascular endothelial cells and macrophages. TNF-α is a key cytokine in the development of several inflammatory disorders. It contributes to the development of type 2 diabetes through its effects on insulin resistance and fatty acid metabolism.

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Citations

Citations of cell biology reagents in peer reviewed literature can be used as a direct measure of product quality. They can also provide crucial insightinto their use under specialized or unique experimental conditions. Because of the importance published citations have to researchers, R&D Systems personnelmanually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but alsoprovides information about sample types, species, and experimental conditions.

Astrocytes acquire resistance to iron-dependent oxidative stress upon proinflammatory activation.
Codazzi F, Consonni A, Giacalone G, Grohovaz F, Macco R, Martinelli Boneschi F, Pelizzoni I, Vitali I, Zacchetti D
J Neuroinflammation 2013 10:130
Species: Rat
Protein Application: Bioassay


Glial tumor necrosis factor alpha (TNF-alpha) generates metaplastic inhibition of spinal learning.
Baumbauer KM, Beattie MS, Bresnahan JC, Ferguson AR, Grau JW, Huie JR, Lee KH
PLoS ONE 2012 7:e39751
Species: Rat
Protein Application: In Vivo


Inhibiting nonmuscle myosin II impedes inflammatory infiltration and ameliorates progressive renal disease.
Ge Y, Gong R, Si J, Zhuang S
Lab. Invest. 2010 90:448-58
Species: Rat
Protein Application: In Vivo


Distribution and tumor necrosis factor-alpha isoform binding specificity of locally administered etanercept into injured and uninjured rat sciatic nerve.
Kato K, Kikuchi S, Myers RR, Shubayev VI
Neuroscience 2009 160:492-500
Species: N/A
Protein Application: Western Blot Control


IL-1beta receptor blockade protects islets against pro-inflammatory cytokine induced necrosis and apoptosis.
Danobeitia JS, Fernandez LA, Greenwood KK, Hanson MS, Schram BR, Schwarznau A, Sperger JM, Vijayan A
J. Cell. Physiol. 2009 220:341-7
Species: Rat
Protein Application: Bioassay


A shed form of LDL receptor-related protein-1 regulates peripheral nerve injury and neuropathic pain in rodents.
Arandjelovic S, Campana WM, Dolkas J, Dragojlovic N, Gaultier A, Gonias SL, Janes J, Li X, Myers RR, Zhou GP
J. Clin. Invest. 2008 118:161-72
Species: Rat
Protein Application: Bioassay


Inhibition of rho family functions by lovastatin promotes myelin repair in ameliorating experimental autoimmune encephalomyelitis.
Paintlia AS, Paintlia MK, Singh AK, Singh I
Mol. Pharmacol. 2008 73:1381-93
Species: Rat
Protein Application: Bioassay


Regulation of tumor necrosis factor receptor-1 and the IKK-NF-kappaB pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor.
Arandjelovic S, Campana WM, Cravatt BF, Fazio S, Gaultier A, Gonias SL, Linton MF, Niessen S, Overton CD
Blood 2008 111:5316-25
Species: Mouse
Protein Application: Bioassay


Deleterious role of TNF-alpha in retinal ischemia-reperfusion injury.
Berger S, David J, Nijhawan S, Rosenbaum DM, Rosenbaum PS, Savitz SI, Singh M
Invest. Ophthalmol. Vis. Sci. 2008 49:3605-10
Species: Rat
Protein Application: In Vivo


Hydralazine reduces leukocyte migration through different mechanisms in spontaneously hypertensive and normotensive rats.
Carvalho MH, de Cassia Tostes R, de Oliveira MA, Dos Santos RA, Fortes ZB, Rodrigues SF, Soares AG
Eur. J. Pharmacol. 2008 589:206-14
Species: Rat
Protein Application: In Vivo


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