IL-6 組換え体(リコンビナント)タンパク質 | Recombinant Rat IL-6
掲載日情報:2015/01/26 現在Webページ番号:112954
R&D Systems社製の高品質なIL-6の組換え体タンパク質(Recombinant Rat IL-6)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 :2024年05月18日 00時00分現在]
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[在庫・価格 :2024年05月18日 00時00分現在]
IL-6, Rat, Recombinant
文献数: 23
- 商品コード:506-RL-010
- メーカー:RSD
- 包装:10μg
- 価格:¥54,000
- 在庫:無(未発注)
- 納期:10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
説明文 |
産生:E. coli,純度:>97%, by SDS-PAGE under reducing conditions and visualized by silver stain,由来動物:Rat,M.W.:22 kDa,Genbank:3569,エンドトキシンレベル:<0.01 EU per 1 µg of the protein by the LAL method. 別名:B cell stimulatory factor-2 Genbank No: 3569 Protein Accession No: P20607.1 |
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保存条件 | -80℃ | 法規備考 | |||||
掲載カタログ |
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製品記事 |
抗幹細胞マーカー抗体/抗造血幹細胞マーカー抗体(R&D Systems社) Helper T Cells Marker Antibodies |
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関連記事 |
IL-6, Rat, Recombinant, Carrier-free
文献数: 0
- 商品コード:506-RL-010/CF
- メーカー:RSD
- 包装:10μg
- 価格:¥54,000
- 在庫:無(未発注)
- 納期:10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
説明文 |
産生:E. coli,純度:>97%, by SDS-PAGE under reducing conditions and visualized by silver stain,由来動物:Rat,M.W.:22 kDa,Genbank:3569,エンドトキシンレベル:<0.01 EU per 1 µg of the protein by the LAL method. 別名:B cell stimulatory factor-2 Genbank No: 3569 Protein Accession No: P20607.1 |
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別包装品 | 別包装品あり | ||||||
法規制等 | |||||||
保存条件 | -80℃ | 法規備考 | |||||
掲載カタログ |
|
||||||
製品記事 |
抗幹細胞マーカー抗体/抗造血幹細胞マーカー抗体(R&D Systems社) Helper T Cells Marker Antibodies |
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関連記事 |
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バルク注文に関して
※バルク包装品も承ります。お気軽にお問合せ下さい。
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CF(Carrier-Free)とは?
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
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Product Details
- Source
- E. coli-derived, Phe25-Thr211, with an N-terminal Met
- Accession
- P20607.1
- Purity
- >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Predicted Molecular Mass
- 22 kDa
- Activity
- Measured in a cell proliferation assay using T1165.85.2.1 mouse plasmacytoma cells. Nordan, R.P. et al. (1987) J. Immunol. 139
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Additional Information
- Molecule Information
- IL-6
- Aliases
- BSF-2; IFN-beta 2; MGI-2A
- Entrez Gene IDs
- 3569 (Human); 16193 (Mouse); 24498 (Rat); 399500 (Porcine); 403985 (Canine); 100034196 (Equine); 493687 (Feline); 100008733 (Rabbit)
- Background
- IL-6
- Interleukin 6 (IL-6), also known as interferon-beta 2, 26 kDa protein and B cell stimulatory factor-2 (BSF-2), is a pleiotropic α-helical cytokine that plays important roles in acute phase reactions, inflammation, hematopoiesis, bone metabolism, and cancer progression. IL-6 activity is essential for the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. It is secreted by multiple cell types as a 22 kDa - 28 kDa phosphorylated and variably glycosylated molecule. Mature human IL-6 is 183 amino acids (aa) in length and shares 41% aa sequence identity with mouse and rat IL-6. Alternate splicing generates several isoforms with internal deletions, some of which exhibit antagonistic properties.IL-6 induces signaling through a cell surface heterodimeric receptor complex composed of a ligand binding subunit (IL-6 R) and a signal transducing subunit (gp130). IL-6 binds to IL-6 R, triggering IL-6 R association with gp130 and gp130 dimerization. gp130 is also a component of the receptors for CLC, CNTF, CT-1, IL-11, IL-27, LIF, and OSM. Soluble forms of IL-6 R are generated by both alternate splicing and proteolytic cleavage. In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6 R elicit responses from gp130-expressing cells that lack cell surface IL-6 R. Trans-signaling enables a wider range of cell types to respond to IL-6, as the expression of gp130 is ubiquitous, while that of IL-6 R is predominantly restricted to hepatocytes, leukocytes, and lymphocytes. Soluble splice forms of gp130 block trans-signaling from IL-6/IL-6 R but not from other cytokines that utilize gp130 as a coreceptor.
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Citations
Citations of cell biology reagents in peer reviewed literature can be used as a direct measure of product quality. They can also provide crucial insightinto their use under specialized or unique experimental conditions. Because of the importance published citations have to researchers, R&D Systems personnelmanually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but alsoprovides information about sample types, species, and experimental conditions.
Astrocyte-derived interleukin-6 promotes specific neuronal differentiation of neural progenitor cells from adult hippocampus.
Blong CC, McCloskey MA, Oh J
J. Neurosci. Res. 2010 88:2798-809
Species: Rat
Protein Application: Bioassay
Fibroblast growth factor inhibits interferon gamma-STAT1 and interleukin 6-STAT3 signaling in chondrocytes.
Bryja V, Jelinkova P, Kozubik A, Krejci P, Pejchalova K, Prochazkova J, Thompson LM, Wilcox WR
Cell. Signal. 2009 21:151-60
Species: Mouse
Protein Application: Bioassay
The anti-inflammatory and anti-angiogenic role of mesenchymal stem cells in corneal wound healing following chemical injury.
Kim MK, Ko JH, Lee HJ, Lee JH, Oh JY, Shin MS, Wee WR
Stem Cells 2008 26:1047-55
Species: Rat
Protein Application: ELISA development
Microglia-derived interleukin-6 and leukaemia inhibitory factor promote astrocytic differentiation of neural stem/progenitor cells.
Akaike A, Kihara T, Matsuda S, Nakanishi M, Niidome T, Sugimoto H
Eur. J. Neurosci. 2007 25:649-58
Species: Rat
Protein Application: Bioassay
Central blockade of melanocortin receptors attenuates the metabolic and locomotor responses to peripheral interleukin-1beta administration.
Reyes TM, Whitaker KW
Neuropharmacology 2007 54:509-20
Species: Rat
Protein Application: In Vivo
Inflammatory signalling pathways involved in astroglial activation by unconjugated bilirubin.
Brites D, Brito MA, Falcao AS, Fernandes A, Gama MJ, Gordo AC, Silva RF
J. Neurochem. 2006 96:1667-79
Species: Rat
Protein Application: Bioassay
In vivo modulation of LPS-induced alterations in brain and peripheral cytokines and HPA axis activity by cannabinoids.
Diamond M, Finn DP, Roche M
J. Neuroimmunol. 2006 181:57-67
Species:
Protein Application: ELISA Standard
The cytokine interleukin-6 is sufficient but not necessary to mimic the peripheral conditioning lesion effect on axonal growth.
Bryson JB, Cao Z, Carmel J, Chaudhry N, Filbin MT, Gao Y, Hart RB, Hou J, Martinez J, Siddiq M, Spencer T
J. Neurosci. 2006 26:5565-73
Species: Rat
Protein Application: Bioassay
Identification of astrocyte-expressed factors that modulate neural stem/progenitor cell differentiation.
Aimone JB, Barkho BZ, Song H
Stem Cells Dev. 2006 15:407-21
Species: Rat
Protein Application: Bioassay
Amphiregulin: an early trigger of liver regeneration in mice.
Avila MA, Berasain C, Castillo J, Erroba E, Garcia-Trevijano ER, Lee DC, Prieto J
Gastroenterology 2005 128:424-32
Species: Rat
Protein Application: Bioassay
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