IL-6 組換え体(リコンビナント)タンパク質 | Recombinant Mouse IL-6
掲載日情報：2015/01/26 現在Webページ番号：112669
R&D Systems社製の高品質なIL-6の組換え体タンパク質(Recombinant Mouse IL-6)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 ：2025年04月26日 09時55分現在]
| 詳細 | 商品名 |
|
文献数 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
IL-6, Mouse, Recombinant |
|
199 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
IL-6, Mouse, Recombinant, Carrier-free |
|
0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
[在庫・価格 ：2025年04月26日 09時55分現在]
IL-6, Mouse, Recombinant
文献数： 199
- 商品コード：406-ML-005
- メーカー：RSD
- 包装：5μg
- 価格：¥59,000
- 在庫：2個
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 産生：E. coli，純度：>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.，由来動物：Mouse，M.W.：21.8 kDa，Genbank：3569，エンドトキシンレベル：<0.10 EU per 1 µg of the protein by the LAL method. 別名：B cell stimulatory factor-2 Genbank No： 3569 Protein Accession No： P08505 |
||||||
|---|---|---|---|---|---|---|---|
| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | -20℃ | 法規備考 | |||||
| 掲載カタログ |
|
||||||
| 製品記事 | 抗幹細胞マーカー抗体／抗造血幹細胞マーカー抗体（R&D Systems社） Helper T Cells Marker Antibodies |
||||||
| 関連記事 | |||||||
IL-6, Mouse, Recombinant, Carrier-free
文献数： 0
- 商品コード：406-ML-005/CF
- メーカー：RSD
- 包装：5μg
- 価格：¥59,000
- 在庫：無(発注済)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 産生：E. coli，純度：>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.，由来動物：Mouse，M.W.：21.8 kDa，Genbank：3569，エンドトキシンレベル：<0.10 EU per 1 µg of the protein by the LAL method. 別名：B cell stimulatory factor-2 Genbank No： 3569 Protein Accession No： P08505 |
||||||
|---|---|---|---|---|---|---|---|
| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | 4℃,凍結禁止 | 法規備考 | |||||
| 掲載カタログ |
|
||||||
| 製品記事 | 抗幹細胞マーカー抗体／抗造血幹細胞マーカー抗体（R&D Systems社） Helper T Cells Marker Antibodies |
||||||
| 関連記事 | |||||||
追加しました。
バルク注文に関して
※バルク包装品も承ります。お気軽にお問合せ下さい。
追加しました。
CF(Carrier-Free)とは？
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
追加しました。
Product Details
- Source
- E. coli-derived, Phe25-Thr211, with an N-terminal Met
- Accession
- P08505
- Purity
- >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Predicted Molecular Mass
- 21.8 kDa
- Activity
- Measured in a cell proliferation assay using T1165.85.2.1 mouse plasmacytoma cells. Nordan, R.P. et al. (1987) J. Immunol. 139
追加しました。
Additional Information
- Molecule Information
- IL-6
- Aliases
- BSF-2; IFN-beta 2; MGI-2A
- Entrez Gene IDs
- 3569 (Human); 16193 (Mouse); 24498 (Rat); 399500 (Porcine); 403985 (Canine); 100034196 (Equine); 493687 (Feline); 100008733 (Rabbit)
- Background
- IL-6
- Interleukin 6 (IL-6), also known as interferon-beta 2, 26 kDa protein and B cell stimulatory factor-2 (BSF-2), is a pleiotropic α-helical cytokine that plays important roles in acute phase reactions, inflammation, hematopoiesis, bone metabolism, and cancer progression. IL-6 activity is essential for the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. It is secreted by multiple cell types as a 22 kDa - 28 kDa phosphorylated and variably glycosylated molecule. Mature human IL-6 is 183 amino acids (aa) in length and shares 41% aa sequence identity with mouse and rat IL-6. Alternate splicing generates several isoforms with internal deletions, some of which exhibit antagonistic properties.IL-6 induces signaling through a cell surface heterodimeric receptor complex composed of a ligand binding subunit (IL-6 R) and a signal transducing subunit (gp130). IL-6 binds to IL-6 R, triggering IL-6 R association with gp130 and gp130 dimerization. gp130 is also a component of the receptors for CLC, CNTF, CT-1, IL-11, IL-27, LIF, and OSM. Soluble forms of IL-6 R are generated by both alternate splicing and proteolytic cleavage. In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6 R elicit responses from gp130-expressing cells that lack cell surface IL-6 R. Trans-signaling enables a wider range of cell types to respond to IL-6, as the expression of gp130 is ubiquitous, while that of IL-6 R is predominantly restricted to hepatocytes, leukocytes, and lymphocytes. Soluble splice forms of gp130 block trans-signaling from IL-6/IL-6 R but not from other cytokines that utilize gp130 as a coreceptor.
追加しました。
Citations
Citations of cell biology reagents in peer reviewed literature can be used as a direct measure of product quality. They can also provide crucial insightinto their use under specialized or unique experimental conditions. Because of the importance published citations have to researchers, R&D Systems personnelmanually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but alsoprovides information about sample types, species, and experimental conditions.
Exposure to atmospheric particulate matter enhances Th17 polarization through the aryl hydrocarbon receptor.
Fechner , John H, Julliard , Walker, Knopp , Samantha, Mezrich , Joshua D, Schauer , James J, van Voorhis , Michael, Zhang , Xiaoji
PLoS ONE 2013 8:e82545
Species: Mouse
Protein Application: cell culture
IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39.
Ben-Hamo , Rotem, Burns , Evan J, Efroni , Sol, Kuchroo , Vijay K, Mascanfroni , Ivan D, Mayo , Lior, Patel , Bonny, Quintana , Francisc, Robson , Simon C, Sloma , Ido, Vieira , Silvio M, Wu , Yan, Yeste , Ada
Nat Immunol 2013 14:1054-63
Species: Mouse
Protein Application: Bioassay
Host-derived MCP-1 and MIP-1alpha regulate protective anti-tumor immunity to localized and metastatic B16 melanoma.
Fujimoto M, Hamaguchi Y, Hasegawa M, Huu DL, Matsushita T, Nakasone Y, Sato S, Takehara K, Yanaba M
Am. J. Pathol. 2012 180:365-74
Species: Mouse
Protein Application: In Vivo
CXCL1 can be regulated by IL-6 and promotes granulocyte adhesion to brain capillaries during bacterial toxin exposure and encephalomyelitis.
Dumas A, Richard JF, Roy M, Vallieres L
J Neuroinflammation 2012 9:18
Species: Mouse
Protein Application: Bioassay
Hepatocyte-specific mutation of both NF-kappaB RelA and STAT3 abrogates the acute phase response in mice.
Akira S, Algul H, Allen E, Blahna MT, Ferrari JD, Hilliard KL, Jones MR, Mizgerd JP, Pelton SI, Quinton LJ, Sabharwal V, Schmid RM, Spira A, Zhang X
J. Clin. Invest. 2012 122:1758-63
Species: Mouse
Protein Application: In Vivo
Hepatocarcinogenesis in FXR-/- mice mimics human HCC progression that operates through HNF1alpha regulation of FXR expression.
Forman BM, Huang W, Lai L, Liu N, Liu X, Lou G, Meng Z, Wang X, Xu R, Xu Z, Yen Y, Zhang L, Zhang Y, Zhou W
Mol. Endocrinol. 2012 26:775-85
Species: Mouse
Protein Application: Bioassay
Sphingosine-1-phosphate enhances satellite cell activation in dystrophic muscles through a S1PR2/STAT3 signaling pathway.
Carlson ME, Leong WI, Loh KC
PLoS ONE 2012 7:e37218
Species: Mouse
Protein Application: Bioassay
IL-6 activates STAT5 in T cells.
Crabe S, Elson G, Gauchat JF, Letellier MC, Sharma M, Tormo AJ
Cytokine 2012 60:575
Species: Mouse
Protein Application: Bioassay
Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells.
Nat. Med. 2012 1248:18
Regulation of innate CD8+ T-cell activation mediated by cytokines.
Proc Natl Acad Sci U S A 2012 109:9971-6
追加しました。
製品情報は掲載時点のものですが、価格表内の価格については随時最新のものに更新されます。お問い合わせいただくタイミングにより製品情報・価格などは変更されている場合があります。
表示価格に、消費税等は含まれていません。一部価格が予告なく変更される場合がありますので、あらかじめご了承下さい。