TGF-beta 2 組換え体(リコンビナント)タンパク質 | Recombinant Human TGF-beta 2
掲載日情報：2015/01/26 現在Webページ番号：112358
R&D Systems社製の高品質なTGF-beta 2の組換え体タンパク質(Recombinant Human TGF-beta 2)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 ：2025年06月06日 20時55分現在]
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TGF-β2, Human, Recombinant <Transforming Growth Factor-β2> |
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TGF-β2, Human, Carrier-free <Transforming Growth Factor-β2> |
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[在庫・価格 ：2025年06月06日 20時55分現在]
TGF-β2, Human, Recombinant <Transforming Growth Factor-β2>
文献数： 54
- 商品コード：302-B2-002
- メーカー：RSD
- 包装：2μg
- 価格：¥91,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 産生：NS0，純度：>97%, by SDS-PAGE under reducing conditions and visualized by silver stain，由来動物：Human，M.W.：12.7 kDa (monomer)，Genbank：7042，エンドトキシンレベル：<0.10 EU per 1 µg of the protein by the LAL method. 別名：BSC-1 cell growth inhibitor Genbank No： 7042 Protein Accession No： P61812 |
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| 保存条件 | -20℃ | 法規備考 | |||||
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| 製品記事 | 抗幹細胞マーカー抗体／抗造血幹細胞マーカー抗体（R&D Systems社） Helper T Cells Marker Antibodies |
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TGF-β2, Human, Carrier-free <Transforming Growth Factor-β2>
文献数： 0
- 商品コード：302-B2-002/CF
- メーカー：RSD
- 包装：2μg
- 価格：¥91,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 産生：NS0，純度：>97%, by SDS-PAGE under reducing conditions and visualized by silver stain，由来動物：Human，M.W.：12.7 kDa (monomer)，Genbank：7042，エンドトキシンレベル：<0.10 EU per 1 µg of the protein by the LAL method. 別名：BSC-1 cell growth inhibitor Genbank No： 7042 Protein Accession No： P61812 |
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| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | -20℃ | 法規備考 | |||||
| 掲載カタログ |
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| 製品記事 | 抗幹細胞マーカー抗体／抗造血幹細胞マーカー抗体（R&D Systems社） Helper T Cells Marker Antibodies |
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バルク注文に関して
※バルク包装品も承ります。お気軽にお問合せ下さい。
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CF(Carrier-Free)とは？
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
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Product Details
- Source
- Mouse myeloma cell line, NS0-derived, Ala303-Ser414
- Accession
- P61812
- Structure
- Disulfide-linked homodimer
- Purity
- >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Predicted Molecular Mass
- 12.7 kDa (monomer)
- SDS-PAGE
- 12 kDa, reducing conditions24 kDa, non-reducing conditions
- Activity
- Measured by its ability to inhibit the IL-4-dependent proliferation of HT‑2 mouse T cells. Tsang, M. et al. (1995) Cytokine 7
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Additional Information
- Molecule Information
- TGF-beta 2
- Aliases
- TGFB2
- Entrez Gene IDs
- 7042 (Human); 21808 (Mouse); 397084 (Porcine)
- Background
- TGF-beta Family Ligands
- Transforming Growth Factor Beta 1, 2, and 3 (TGF-beta 1, TGF-beta 2, and TGF-beta 3) are highly pleiotropic cytokines that virtually all cell types secrete. TGF-beta molecules are proposed to act as cellular switches that regulate processes such as immune function, proliferation, and epithelial-mesenchymal transition. Targeted deletions of these genes in mice show that each TGF-beta isoform has some non-redundant functions: TGF-beta 1 is involved in hematopoiesis and endothelial differentiation; TGF-beta 2 affects development of cardiac, lung, craniofacial, limb, eye, ear, and urogenital systems; and TGF-beta 3 influences palatogenesis and pulmonary development. The full range of in vitro biological activities of TGF-beta 5 has not yet been explored. However, TGF-beta 1, TGF-beta 2, TGF-beta 3, and TGF-beta 5 have been found to be largely interchangeable in an inhibitory bioassay, and it is anticipated that TGF-beta 5 will show a spectrum of activities similar to the other TGF-beta family members. To date, the production of TGF-beta 5 has only been demonstrated in Xenopus.TGF-beta ligands are initially synthesized as precursor proteins that undergo proteolytic cleavage. The mature segments form active ligand dimers via a disulfide-rich core consisting of the characteristic 'cysteine knot'. TGF-beta signaling begins with binding to a complex of the accessory receptor betaglycan (also known as TGF-beta RIII) and a type II serine/threonine kinase receptor termed TGF-beta RII. This receptor then phosphorylates and activates a type I serine/threonine kinase receptor, either ALK-1 or TGF-beta RI (also called ALK-5). The activated type I receptor phosphorylates and activates Smad proteins that regulate transcription. Use of other signaling pathways that are Smad-independent allows for distinct actions observed in response to TGF-beta in different contexts.
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Citations
Citations of cell biology reagents in peer reviewed literature can be used as a direct measure of product quality. They can also provide crucial insightinto their use under specialized or unique experimental conditions. Because of the importance published citations have to researchers, R&D Systems personnelmanually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but alsoprovides information about sample types, species, and experimental conditions.
Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
Burton L, Chan E, Fridlyand J, Koeppen H, Li J, Lin E, Merchant M, Moffat J, Neve R, Peng J, Penuel E, Ribas A, Settleman J, Sosman J, Sutherlin DP, Wang Y, Wilson TR, Yan Y
Nature 2012 487:505-9
Species: Human
Protein Application: Bioassay
TGFbeta signalling plays an important role in IL4-induced alternative activation of microglia.
J Neuroinflammation 2012 9:210
Species: Mouse
Protein Application: Bioassay
Transforming growth factor-beta regulates basal transcriptional regulatory machinery to control cell proliferation and differentiation in cranial neural crest-derived osteoprogenitor cells.
Chai Y, Hosokawa R, Iwata J, Sanchez-Lara PA, Slavkin H, Urata M
J. Biol. Chem. 2011 285:4975-82
Species: Mouse
Protein Application: In Vivo
Thrombospondin 1 inhibits inflammatory lymphangiogenesis by CD36 ligation on monocytes.
Bock F, Cursiefen C, Dana R, Lawler J, Maruyama K, Masli S, Saban D, Sadrai Z
J. Exp. Med. 2011 208:1083-92
Species: Mouse
Protein Application: Bioassay
An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition.
Bert AG, Bracken CP, Drew PA, Farshid G, Goodall GJ, Gregory PA, Khew-Goodall Y, Lim YY, Lindeman GJ, Morris M, Roslan S, Shannon MF, Smith E, Wright JA, Wyatt L
Mol. Biol. Cell 2011 22:1686-98
Species: Canine
Protein Application: Bioassay
TGFbeta2-mediated production of hyaluronan is important for the induction of epicardial cell differentiation and invasion.
Austin AF, Barnett JV, Camenisch TD, Craig EA, Vaillancourt RR
Exp. Cell Res. 2010 316:3397-405
Species: Mouse
Protein Application: Bioassay
Angiopoietin-like 7 secretion is induced by glaucoma stimuli and its concentration is elevated in glaucomatous aqueous humor.
Gelatt KN, Kallberg ME, Komaromy AM, Kuchtey J, Kuchtey RW, Rinkoski T
Invest. Ophthalmol. Vis. Sci. 2008 49:3438-48
Species: Human
Protein Application: Bioassay
Activation of transforming growth factor-beta by the integrin alphavbeta8 delays epithelial wound closure.
Neurohr C, Nishimura SL, Sheppard D
Am. J. Respir. Cell Mol. Biol. 2006 35:252-9
Species: Human
Protein Application: Bioassay
Identification of astrocyte-expressed factors that modulate neural stem/progenitor cell differentiation.
Aimone JB, Barkho BZ, Song H
Stem Cells Dev. 2006 15:407-21
Species: Rat
Protein Application: Bioassay
Expression of PDGF and their receptors in human retinal pigment epithelial cells and fibroblasts: regulation by TGF-beta.
Detrick B, Hooks JJ, Kutty V, Nagineni CN
J. Cell. Physiol. 2005 203:35-43
Species: Human
Protein Application: Bioassay
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