Latent TGF-beta 1 組換え体(リコンビナント)タンパク質 | Recombinant Human Latent TGF-beta 1
掲載日情報：2015/01/26 現在Webページ番号：112348
R&D Systems社製の高品質なLatent TGF-beta 1の組換え体タンパク質(Recombinant Human Latent TGF-beta 1)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 ：2025年05月06日 15時55分現在]
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TGF-β1, Latent, Human, Recombinant <Transforming Growth Factor-β1 Latent> |
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本製品は取扱中止になりました | 17 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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TGF-β1, Latent, Human, Recombinant, Carrier-free <Transforming Growth Factor-β1 Latent> |
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本製品は取扱中止になりました | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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[在庫・価格 ：2025年05月06日 15時55分現在]
TGF-β1, Latent, Human, Recombinant <Transforming Growth Factor-β1 Latent>
文献数： 17
- 商品コード：299-LT-005
- メーカー：RSD
- 包装：5μg
- 本製品は取扱中止になりました
| 説明文 | Genbank No：
7040
Protein Accession No： P01137 |
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| 保存条件 | 法規備考 | ||||||
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| 製品記事 | 抗幹細胞マーカー抗体／抗造血幹細胞マーカー抗体（R&D Systems社） Helper T Cells Marker Antibodies |
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TGF-β1, Latent, Human, Recombinant, Carrier-free <Transforming Growth Factor-β1 Latent>
文献数： 0
- 商品コード：299-LT-005/CF
- メーカー：RSD
- 包装：5μg
- 本製品は取扱中止になりました
| 説明文 | Genbank No：
7040
Protein Accession No： P01137 |
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| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | 法規備考 | ||||||
| 掲載カタログ |
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| 製品記事 | 抗幹細胞マーカー抗体／抗造血幹細胞マーカー抗体（R&D Systems社） Helper T Cells Marker Antibodies |
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バルク注文に関して
※バルク包装品も承ります。お気軽にお問合せ下さい。
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CF(Carrier-Free)とは？
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
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Product Details
- Source
- Chinese Hamster Ovary cell line, CHO-derived, Leu30-Ser390
- Accession
- P01137
- Purity
- >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Predicted Molecular Mass
- 41.3 kDa (monomer)
- SDS-PAGE
- 40-43 kDa & 12 kDa, reducing conditions80-90 kDa, non-reducing conditions
- Activity
- Measured by its ability to inhibit the IL-4-dependent proliferation of HT‑2 mouse T cells. Tsang, M. et al. (1995) Cytokine 7
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Additional Information
- Molecule Information
- TGF-beta 1
- Aliases
- TGFB1
- Entrez Gene IDs
- 7040 (Human); 21803 (Mouse); 59086 (Rat); 397078 (Porcine)
- Background
- TGF-beta Family Ligands
- Transforming Growth Factor Beta 1, 2, and 3 (TGF-beta 1, TGF-beta 2, and TGF-beta 3) are highly pleiotropic cytokines that virtually all cell types secrete. TGF-beta molecules are proposed to act as cellular switches that regulate processes such as immune function, proliferation, and epithelial-mesenchymal transition. Targeted deletions of these genes in mice show that each TGF-beta isoform has some non-redundant functions: TGF-beta 1 is involved in hematopoiesis and endothelial differentiation; TGF-beta 2 affects development of cardiac, lung, craniofacial, limb, eye, ear, and urogenital systems; and TGF-beta 3 influences palatogenesis and pulmonary development. The full range of in vitro biological activities of TGF-beta 5 has not yet been explored. However, TGF-beta 1, TGF-beta 2, TGF-beta 3, and TGF-beta 5 have been found to be largely interchangeable in an inhibitory bioassay, and it is anticipated that TGF-beta 5 will show a spectrum of activities similar to the other TGF-beta family members. To date, the production of TGF-beta 5 has only been demonstrated in Xenopus.TGF-beta ligands are initially synthesized as precursor proteins that undergo proteolytic cleavage. The mature segments form active ligand dimers via a disulfide-rich core consisting of the characteristic 'cysteine knot'. TGF-beta signaling begins with binding to a complex of the accessory receptor betaglycan (also known as TGF-beta RIII) and a type II serine/threonine kinase receptor termed TGF-beta RII. This receptor then phosphorylates and activates a type I serine/threonine kinase receptor, either ALK-1 or TGF-beta RI (also called ALK-5). The activated type I receptor phosphorylates and activates Smad proteins that regulate transcription. Use of other signaling pathways that are Smad-independent allows for distinct actions observed in response to TGF-beta in different contexts.
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Citations
Citations of cell biology reagents in peer reviewed literature can be used as a direct measure of product quality. They can also provide crucial insightinto their use under specialized or unique experimental conditions. Because of the importance published citations have to researchers, R&D Systems personnelmanually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but alsoprovides information about sample types, species, and experimental conditions.
The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-beta1 production and FcRL4 expression.
Arthos J, Cicala C, Cimbro R, David A, Fauci A, Hiatt J, Huang D, Hwang I, Jelicic K, Kehrl J, Lempicki R, Nawaz F, Okwara N, Pascuccio M, Roby G, Schwing C, Van Ryk D, Wei D, Yang J, Zheng X
Nat Immunol 2013 14:1256-65
Species: Human
Protein Application: Bioassay
Calpain mediates pulmonary vascular remodeling in rodent models of pulmonary hypertension, and its inhibition attenuates pathologic features of disease.
Caldwell RW, Greer PA, Han W, Ma W, Su Y, Toque HA, Tuder RM, Wang KK
J. Clin. Invest. 2011 121:4548-66
Species: Porcine
Protein Application: activation
Membrane protein GARP is a receptor for latent TGF-beta on the surface of activated human Treg.
Colau D, Coulie PG, Lucas S, Stockis J
Eur. J. Immunol. 2009 39:3315-22
Species: Human
Protein Application: Binding Assay
Antibody-mediated blockade of integrin alpha v beta 6 inhibits tumor progression in vivo by a transforming growth factor-beta-regulated mechanism.
Dolinski BM, Fawell SE, Gardner HA, Gown AM, Heaney G, Ho S, Horan GS, Kelly R, Leone DR, LePage DJ, McCoon PE, Rayhorn P, Reid C, Simon KJ, Skelly MM, Tao N, Thomas GJ, Van Aarsen LA, Violette SM, Weinreb PH
Cancer Res. 2008 68:561-70
Species: Human
Protein Application: Bioassay
Metastable tolerance to rhesus monkey renal transplants is correlated with allograft TGF-beta 1+CD4+ T regulatory cell infiltrates.
Bontrop R, Burlingham WJ, Doxiadis G, Fechner JH, Hamawy MM, Hu H, Jankowska-Gan E, Jonker M, Katayama M, Knechtle SJ, Kusaka S, Schultz JM, Torrealba JR, Wubben J
J. Immunol. 2004 172:5753-64
Species: N/A
Protein Application: Western Blot Control
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