LAP 組換え体(リコンビナント)タンパク質 | Recombinant Human LAP
掲載日情報：2015/01/26 現在Webページ番号：112119
R&D Systems社製の高品質なLAPの組換え体タンパク質(Recombinant Human LAP)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 ：2025年08月02日 20時35分現在]
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LAP/TGF-β1, Human, Recombinant, Carrier-Free |
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[在庫・価格 ：2025年08月02日 20時35分現在]
LAP/TGF-β1, Human, Recombinant
文献数： 24
- 商品コード：246-LP-025
- メーカー：RSD
- 包装：25μg
- 価格：¥79,000
- 在庫：1個
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：カルタヘナ該当品
| 説明文 | 産生：Sf 21 (baculovirus)，純度：>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by CoomassieR Blue Staining.，由来動物：Human，M.W.：27 kDa (monomer)，Genbank：7040，エンドトキシンレベル：<0.10 EU per 1 μg of the protein by the LAL method. 別名：LAP (TGF-beta 1) Genbank No： 7040 Protein Accession No： P01137.2 |
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| 法規制等 | カルタヘナ該当品 | ||
| 保存条件 | -20℃ | 法規備考 | |
| 掲載カタログ |
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| 製品記事 | 抗幹細胞マーカー抗体／抗造血幹細胞マーカー抗体（R&D Systems社） Helper T Cells Marker Antibodies |
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LAP/TGF-β1, Human, Recombinant, Carrier-Free
文献数： 0
- 商品コード：246-LP-025/CF
- メーカー：RSD
- 包装：25μg
- 価格：¥79,000
- 在庫：1個
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：カルタヘナ該当品
| 説明文 | 産生：Sf 21 (baculovirus)，純度：>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by CoomassieR Blue Staining.，由来動物：Human，M.W.：27 kDa (monomer)，Genbank：7040，エンドトキシンレベル：<0.10 EU per 1 μg of the protein by the LAL method. 別名：LAP (TGF-beta 1) Genbank No： 7040 Protein Accession No： P01137.2 |
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| 法規制等 | カルタヘナ該当品 | ||
| 保存条件 | -20℃ | 法規備考 | |
| 掲載カタログ |
|
||
| 製品記事 | 抗幹細胞マーカー抗体／抗造血幹細胞マーカー抗体（R&D Systems社） Helper T Cells Marker Antibodies |
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バルク注文に関して
※バルク包装品も承ります。お気軽にお問合せ下さい。
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CF(Carrier-Free)とは？
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
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Product Details
- Source
- Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Leu30-Arg278 (Cys33Ser)
- Accession
- P01137.2
- Structure
- Disulfide-linked homodimer
- Purity
- >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Predicted Molecular Mass
- 27 kDa (monomer)
- SDS-PAGE
- 28-36 kDa, reducing & 60-70 kDa, non-reducing conditions (variably glycosylated)
- Activity
- Measured by its ability to inhibit TGF-beta 1 activity on HT‑2 mouse T cells. Tsang, M. et al. (1995) Cytokine 7
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Additional Information
- Molecule Information
- LAP (TGF-beta 1)
- Aliases
- undefined
- Entrez Gene IDs
- 7040 (Human)
- Background
- TGF-beta Family Ligands
- Transforming Growth Factor Beta 1, 2, and 3 (TGF-beta 1, TGF-beta 2, and TGF-beta 3) are highly pleiotropic cytokines that virtually all cell types secrete. TGF-beta molecules are proposed to act as cellular switches that regulate processes such as immune function, proliferation, and epithelial-mesenchymal transition. Targeted deletions of these genes in mice show that each TGF-beta isoform has some non-redundant functions: TGF-beta 1 is involved in hematopoiesis and endothelial differentiation; TGF-beta 2 affects development of cardiac, lung, craniofacial, limb, eye, ear, and urogenital systems; and TGF-beta 3 influences palatogenesis and pulmonary development. The full range of in vitro biological activities of TGF-beta 5 has not yet been explored. However, TGF-beta 1, TGF-beta 2, TGF-beta 3, and TGF-beta 5 have been found to be largely interchangeable in an inhibitory bioassay, and it is anticipated that TGF-beta 5 will show a spectrum of activities similar to the other TGF-beta family members. To date, the production of TGF-beta 5 has only been demonstrated in Xenopus.TGF-beta ligands are initially synthesized as precursor proteins that undergo proteolytic cleavage. The mature segments form active ligand dimers via a disulfide-rich core consisting of the characteristic 'cysteine knot'. TGF-beta signaling begins with binding to a complex of the accessory receptor betaglycan (also known as TGF-beta RIII) and a type II serine/threonine kinase receptor termed TGF-beta RII. This receptor then phosphorylates and activates a type I serine/threonine kinase receptor, either ALK-1 or TGF-beta RI (also called ALK-5). The activated type I receptor phosphorylates and activates Smad proteins that regulate transcription. Use of other signaling pathways that are Smad-independent allows for distinct actions observed in response to TGF-beta in different contexts.
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Citations
Citations of cell biology reagents in peer reviewed literature can be used as a direct measure of product quality. They can also provide crucial insightinto their use under specialized or unique experimental conditions. Because of the importance published citations have to researchers, R&D Systems personnelmanually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but alsoprovides information about sample types, species, and experimental conditions.
Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche.
Ema H, Iwama A, Karlsson G, Karlsson S, Miyoshi H, Nakauchi H, Shioda S, Taketo MM, Yamaguchi T, Yamazaki S
Cell 2011 147:1146-58
Species: Mouse
Protein Application: In Vivo
Analysis of adhesion molecules, target cells, and role of IL-2 in human FOXP3+ regulatory T cell suppressor function.
Darnell DA, Glass DD, Holland SM, Shevach EM, Spalding C, Tran DQ, Uzel G
J. Immunol. 2009 182:2929-38
Species: Mouse
Protein Application: Bioassay
Antibody-mediated blockade of integrin alpha v beta 6 inhibits tumor progression in vivo by a transforming growth factor-beta-regulated mechanism.
Dolinski BM, Fawell SE, Gardner HA, Gown AM, Heaney G, Ho S, Horan GS, Kelly R, Leone DR, LePage DJ, McCoon PE, Rayhorn P, Reid C, Simon KJ, Skelly MM, Tao N, Thomas GJ, Van Aarsen LA, Violette SM, Weinreb PH
Cancer Res. 2008 68:561-70
Species: Human
Protein Application: Bioassay
The aberrant methylation of TSP1 suppresses TGF-beta1 activation in colorectal cancer.
Grady WM, Kim YH, Markowitz SD, Meherem S, Rojas A, Washington MK, Willis JE
Int. J. Cancer 2008 123:14-21
Species: Porcine
Protein Application: Bioassay
Human anti-inflammatory macrophages induce Foxp3+ GITR+ CD25+ regulatory T cells, which suppress via membrane-bound TGFbeta-1.
De Boer T, Geluk A, Joosten SA, Ottenhoff TH, Savage ND, van Meijgaarden K, Walburg KV
J. Immunol. 2008 181:2220-6
Species: Human
Protein Application: Bioassay
Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function.
Baker SR, Blazar BR, Ge YG, Godfrey WR, June CH, Levine BL, Liu B, Porter SB, Spoden DJ
Blood 2005 105:750-8
Species: Human
Protein Application: Bioassay
TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice.
Fuss I, Kitani A, Nawata H, Pedersen A
J. Immunol. 2004 172:834-42
Species: Mouse
Protein Application: Bioassay
Latency-associated peptide prevents skin fibrosis in murine sclerodermatous graft-versus-host disease, a model for human scleroderma.
Gilliam AC, McCormick LL, Zhang Y
J. Invest. Dermatol. 2003 121:713-9
Species: Mouse
Protein Application: In Vivo
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