TGF-beta 3 組換え体(リコンビナント)タンパク質 | Recombinant Human TGF-beta 3
掲載日情報：2015/01/26 現在Webページ番号：112106
R&D Systems社製の高品質なTGF-beta 3の組換え体タンパク質(Recombinant Human TGF-beta 3)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 ：2025年12月14日 00時00分現在]
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TGF-β3, Human, Recombinant <Transforming Growth Factor-β3> |
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TGF-β3, Human, Recombinant, Carrier-free |
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[在庫・価格 ：2025年12月14日 00時00分現在]
TGF-β3, Human, Recombinant <Transforming Growth Factor-β3>
文献数： 75
- 商品コード：243-B3-002
- メーカー：RSD
- 包装：2μg
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価格：
¥70,000特別価格 ¥49,000 - 在庫：1個
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：カルタヘナ該当品
| キャンペーン期間 |
2025/12/01 ～ 2026/02/27
[RSD]厳選 抗体＆リコンビナントタンパク質 30％OFFキャンペーン[～2026/02/27] |
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| 説明文 | 産生：Sf 21 (baculovirus)，純度：>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.，由来動物：Human，M.W.：12.7 kDa (monomer)，Genbank：7043，エンドトキシンレベル：<0.01 EU per 1 µg of the protein by the LAL method. 別名：ARVD Genbank No： 7043 Protein Accession No： P10600 |
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| 別包装品 | 別包装品あり | ||||||
| 法規制等 | カルタヘナ該当品 | ||||||
| 保存条件 | -20℃ | 法規備考 | |||||
| 掲載カタログ |
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| 製品記事 | 抗幹細胞マーカー抗体／抗造血幹細胞マーカー抗体（R&D Systems社） Helper T Cells Marker Antibodies |
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| 関連記事 | R&D Systems 製品WHO Unit Conversion Table |
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TGF-β3, Human, Recombinant, Carrier-free
文献数： 0
- 商品コード：243-B3-002/CF
- メーカー：RSD
- 包装：2μg
- 価格：¥70,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：カルタヘナ該当品
| 説明文 | 産生：Sf 21 (baculovirus)，純度：>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.，由来動物：Human，M.W.：12.7 kDa (monomer)，Genbank：7043，エンドトキシンレベル：<0.01 EU per 1 µg of the protein by the LAL method. 別名：ARVD Genbank No： 7043 Protein Accession No： P10600 |
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| 別包装品 | 別包装品あり | ||||||
| 法規制等 | カルタヘナ該当品 | ||||||
| 保存条件 | -20℃ | 法規備考 | |||||
| 掲載カタログ |
|
||||||
| 製品記事 | 抗幹細胞マーカー抗体／抗造血幹細胞マーカー抗体（R&D Systems社） Helper T Cells Marker Antibodies |
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| 関連記事 | R&D Systems 製品WHO Unit Conversion Table |
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追加しました。
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2025/12/01
試薬 特別価格
[RSD]厳選 抗体＆リコンビナントタンパク質 30％OFFキャンペーン[～2026/02/27]
期間：2025/12/01 ～2026/02/27
R&D Systems, Inc.（RSD）
バルク注文に関して
※バルク包装品も承ります。お気軽にお問合せ下さい。
追加しました。
CF(Carrier-Free)とは？
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
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Product Details
- Source
- Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Ala301-Ser412 (Tyr340Phe)
- Accession
- P10600
- Structure
- Disulfide-linked homodimer
- Purity
- >97%, by SDS-PAGE with silver staining.
- Predicted Molecular Mass
- 12.7 kDa (monomer)
- SDS-PAGE
- 12 kDa, reducing conditions24 kDa, non-reducing conditions
- Activity
- Measured by its ability to inhibit the IL-4-dependent proliferation of HT‑2 mouse T cells. Tsang, M. et al. (1995) Cytokine 7
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Additional Information
- Molecule Information
- TGF-beta 3
- Aliases
- TGFB3
- Entrez Gene IDs
- 7043 (Human); 21809 (Mouse); 25717 (Rat)
- Background
- TGF-beta Family Ligands
- Transforming Growth Factor Beta 1, 2, and 3 (TGF-beta 1, TGF-beta 2, and TGF-beta 3) are highly pleiotropic cytokines that virtually all cell types secrete. TGF-beta molecules are proposed to act as cellular switches that regulate processes such as immune function, proliferation, and epithelial-mesenchymal transition. Targeted deletions of these genes in mice show that each TGF-beta isoform has some non-redundant functions: TGF-beta 1 is involved in hematopoiesis and endothelial differentiation; TGF-beta 2 affects development of cardiac, lung, craniofacial, limb, eye, ear, and urogenital systems; and TGF-beta 3 influences palatogenesis and pulmonary development. The full range of in vitro biological activities of TGF-beta 5 has not yet been explored. However, TGF-beta 1, TGF-beta 2, TGF-beta 3, and TGF-beta 5 have been found to be largely interchangeable in an inhibitory bioassay, and it is anticipated that TGF-beta 5 will show a spectrum of activities similar to the other TGF-beta family members. To date, the production of TGF-beta 5 has only been demonstrated in Xenopus.TGF-beta ligands are initially synthesized as precursor proteins that undergo proteolytic cleavage. The mature segments form active ligand dimers via a disulfide-rich core consisting of the characteristic 'cysteine knot'. TGF-beta signaling begins with binding to a complex of the accessory receptor betaglycan (also known as TGF-beta RIII) and a type II serine/threonine kinase receptor termed TGF-beta RII. This receptor then phosphorylates and activates a type I serine/threonine kinase receptor, either ALK-1 or TGF-beta RI (also called ALK-5). The activated type I receptor phosphorylates and activates Smad proteins that regulate transcription. Use of other signaling pathways that are Smad-independent allows for distinct actions observed in response to TGF-beta in different contexts.
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Citations
Citations of cell biology reagents in peer reviewed literature can be used as a direct measure of product quality. They can also provide crucial insightinto their use under specialized or unique experimental conditions. Because of the importance published citations have to researchers, R&D Systems personnelmanually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but alsoprovides information about sample types, species, and experimental conditions.
Human embryonic stem cell-derived mesenchymal stroma cells (hES-MSCs) engraft in vivo and support hematopoiesis without suppressing immune function: implications for off-the shelf ES-MSC therapies.
Hyllner J, Le Blanc K, Li O, Scheding S, Sundberg B, Tormin A
PLoS ONE 2013 8:e55319
Species: Human
Protein Application: Cell Culture Substrate
Molecular characterization of prospectively isolated multipotent mesenchymal progenitors provides new insight into the cellular identity of mesenchymal stem cells in mouse bone marrow.
Badaloni A, Chiara F, Consalez G, Nihlberg K, Polisetti N, Qian H, Sigvardsson M, Stjernberg J
Mol Cell Biol 2013 33:661-77
Species: Mouse
Protein Application: Bioassay
Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
Burton L, Chan E, Fridlyand J, Koeppen H, Li J, Lin E, Merchant M, Moffat J, Neve R, Peng J, Penuel E, Ribas A, Settleman J, Sosman J, Sutherlin DP, Wang Y, Wilson TR, Yan Y
Nature 2012 487:505-9
Species: Human
Protein Application: Bioassay
Primary Mesenchymal Stem and Progenitor Cells from Bone Marrow Lack Expression of CD44 Protein.
Le Blanc K, Qian H, Sigvardsson M
J. Biol. Chem. 2012 287:25795-807
Species: Human
Protein Application: Bioassay
Transforming growth factor Beta 3 is required for excisional wound repair in vivo.
Biggs L, Dunnwald M, Kaartinen V, Le M, Morrison J, Naridze R, Rhea L, Schutte B
PLoS ONE 2012 7:e48040
Species: Mouse
Protein Application: In Vivo
Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth.
Castonguay R, Grinberg AV, Kumar R, Matthews RG, Mulivor AW, Pearsall RS, Presman E, Sako D, Seehra J, Solban N, Underwood KW, Werner ED
J. Biol. Chem. 2011 286:30034-46
Species: Human
Protein Application: Surface Plasmon Resonance
An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition.
Bert AG, Bracken CP, Drew PA, Farshid G, Goodall GJ, Gregory PA, Khew-Goodall Y, Lim YY, Lindeman GJ, Morris M, Roslan S, Shannon MF, Smith E, Wright JA, Wyatt L
Mol. Biol. Cell 2011 22:1686-98
Species: Canine
Protein Application: Bioassay
Age-related changes in rat bone-marrow mesenchymal stem cell plasticity.
Asumda FZ, Chase PB
BMC Cell Biol. 2011 12:44
Species: Rat
Protein Application: Bioassay
Isolation and propagation of enteric neural crest progenitor cells from mouse embryonic stem cells and embryos.
Faial T, Gierl MS, Kawaguchi J, Nichols J, Smith A
Development 2010 137:693-704
Species: Mouse
Protein Application: Bioassay
Expression of the HGF receptor c-met by macrophages in experimental autoimmune encephalomyelitis.
Fontana A, Moransard M, Sawitzky M, Suter T
Glia 2010 58:559-71
Species: Mouse
Protein Application: Bioassay
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