IL-6 組換え体(リコンビナント)タンパク質 | Recombinant Human IL-6
掲載日情報：2015/01/26 現在Webページ番号：111929
R&D Systems社製の高品質なIL-6の組換え体タンパク質(Recombinant Human IL-6)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 ：2025年04月25日 12時35分現在]
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IL-6, Human, Recombinant, Carrier-free |
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[在庫・価格 ：2025年04月25日 12時35分現在]
IL-6, Human, Recombinant
文献数： 320
- 商品コード：206-IL-010
- メーカー：RSD
- 包装：10μg
- 価格：¥59,000
- 在庫：3個以上
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 産生：E. coli，純度：>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.，由来動物：Human，M.W.：20.3 kDa，Genbank：3569，エンドトキシンレベル：<0.10 EU per 1 µg of the protein by the LAL method. 別名：B cell stimulatory factor-2 Genbank No： 3569 Protein Accession No： Q75MH2 |
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| 保存条件 | -20℃ | 法規備考 | |||||
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| 製品記事 | 抗幹細胞マーカー抗体／抗造血幹細胞マーカー抗体（R&D Systems社） Helper T Cells Marker Antibodies |
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IL-6, Human, Recombinant, Carrier-free
文献数： 1
| 説明文 | Genbank No：
3569
Protein Accession No： Q75MH2 |
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| 製品記事 | 抗幹細胞マーカー抗体／抗造血幹細胞マーカー抗体（R&D Systems社） Helper T Cells Marker Antibodies |
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バルク注文に関して
※バルク包装品も承ります。お気軽にお問合せ下さい。
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CF(Carrier-Free)とは？
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
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Product Details
- Source
- E. coli-derived, Pro29-Met212
- Accession
- Q75MH2
- Purity
- >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Predicted Molecular Mass
- 20.3 kDa
- Activity
- Measured in a cell proliferation assay using T1165.85.2.1 mouse plasmacytoma cells. Nordan, R.P. et al. (1987) J. Immunol. 139
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Additional Information
- Molecule Information
- IL-6
- Aliases
- BSF-2; IFN-beta 2; MGI-2A
- Entrez Gene IDs
- 3569 (Human); 16193 (Mouse); 24498 (Rat); 399500 (Porcine); 403985 (Canine); 100034196 (Equine); 493687 (Feline); 100008733 (Rabbit)
- Background
- IL-6
- Interleukin 6 (IL-6), also known as interferon-beta 2, 26 kDa protein and B cell stimulatory factor-2 (BSF-2), is a pleiotropic α-helical cytokine that plays important roles in acute phase reactions, inflammation, hematopoiesis, bone metabolism, and cancer progression. IL-6 activity is essential for the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. It is secreted by multiple cell types as a 22 kDa - 28 kDa phosphorylated and variably glycosylated molecule. Mature human IL-6 is 183 amino acids (aa) in length and shares 41% aa sequence identity with mouse and rat IL-6. Alternate splicing generates several isoforms with internal deletions, some of which exhibit antagonistic properties.IL-6 induces signaling through a cell surface heterodimeric receptor complex composed of a ligand binding subunit (IL-6 R) and a signal transducing subunit (gp130). IL-6 binds to IL-6 R, triggering IL-6 R association with gp130 and gp130 dimerization. gp130 is also a component of the receptors for CLC, CNTF, CT-1, IL-11, IL-27, LIF, and OSM. Soluble forms of IL-6 R are generated by both alternate splicing and proteolytic cleavage. In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6 R elicit responses from gp130-expressing cells that lack cell surface IL-6 R. Trans-signaling enables a wider range of cell types to respond to IL-6, as the expression of gp130 is ubiquitous, while that of IL-6 R is predominantly restricted to hepatocytes, leukocytes, and lymphocytes. Soluble splice forms of gp130 block trans-signaling from IL-6/IL-6 R but not from other cytokines that utilize gp130 as a coreceptor.
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Citations
Citations of cell biology reagents in peer reviewed literature can be used as a direct measure of product quality. They can also provide crucial insightinto their use under specialized or unique experimental conditions. Because of the importance published citations have to researchers, R&D Systems personnelmanually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but alsoprovides information about sample types, species, and experimental conditions.
Inflammation regulates TMPRSS6 expression via STAT5.
Babitt , Jodie L, Chen , Shanzhuo, Chen , Wenjie, Lin , Herbert , Meynard , Delphine, Nelson , Caroline, Sun , Chia Chi, Waters , Michael , Wu , Qifang
PLoS ONE 2013 8:e82127
Species: Human
Protein Application: Bioassay
Pathogen-induced human TH17 cells produce IFN-gamma or IL-10 and are regulated by IL-1beta.
Aschenbrenner D, Gattorno M, Jarrossay D, Lanzavecchia A, Mele F, Monticelli S, Ronchi F, Sallusto F, Zielinski CE
Nature 2012 484:514-8
Species: Human
Protein Application: Bioassay
Targeting of macrophage galactose-type C-type lectin (MGL) induces DC signaling and activation.
Bellati F, Belleudi F, Clausen H, Frati L, Irimura T, Napoletano C, Nuti M, Pierelli L, Rahimi H, Rughetti A, Wandall HH, Zizzari IG
Eur. J. Immunol. 2012 42:936-45
Species: Human
Protein Application: Bioassay
The C-type Lectin Receptor CLECSF8 (CLEC4D) Is Expressed by Myeloid Cells and Triggers Cellular Activation through Syk Kinase.
Brown GD, Campanero-Rhodes MA, Dennehy KM, Feizi T, Graham LM, Guler R, Gupta V, Hornsell WG, Kim SK, Kimberg M, Palma AS, Reid DM, Schafer G, Sobieszczuk P, Willment JA
J. Biol. Chem. 2012 287:25964-74
Species: Human
Protein Application: Bioassay
The reactivity, distribution and abundance of Non-astrocytic Inner Retinal Glial (NIRG) cells are regulated by microglia, acute damage, and IGF1.
Fischer A, Scott M, Volkov L, Zelinka C
PLoS ONE 2012 7:e44477
Species: Chicken
Protein Application: In Vivo
Mycobacterium tuberculosis infection and tissue factor expression in macrophages.
Kothari H, Pendurthi U, Rao L, Vankayalapati R
PLoS ONE 2012 7:e45700
CD4 T follicular helper cell dynamics during SIV infection.
J. Clin. Invest. 2012 122:3281-94
Species: Primate - Macaca mulatta (Rhesus monkey)
Protein Application: Bioassay
Regulation of the formyl peptide receptor 1 (FPR1) gene in primary human macrophages.
Gemperle C, Herova M, Hersberger M, Loretz C, Marti-Jaun J, Schmid M, Wuest S
PLoS ONE 2012 7:e50195
Increased numbers of immature plasma cells in peripheral blood specifically overexpress chemokine receptor CXCR3 and CXCR4 in patients with ulcerative colitis.
Arakawa T, Fujiwara Y, Hirakawa K, Hosomi S, Kamata N, Maeda K, Okazaki H, Oshitani N, Sogawa M, Tanigawa T, Tominaga K, Watanabe K, Watanabe T, Yamagami H
Clin. Exp. Immunol. 2011 163:215-24
Species: Human
Protein Application: Bioassay
Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages.
Leonard WJ, Li P, Liao W, Lin JX, Wang L
Nat. Immunol. 2011 12:551-9
Species: Human
Protein Application: Bioassay
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