How to search

HOME> Products> Molecular Biology> Gene Control Reagent : PIPA
HOME> Products> Natural and Chemical compound> Gene Control Reagent : PIPA

Gene Control Reagent : PIPA

Date：February 16 2017Web Page No：80767

Alternative gene silencer other than siRNA or PNA
PIPA (Py-Im-Polyamide)

PIPA (Py-Im-Polyamide)

PIPA (Py-Im-Polyamide) is a gene expression control reagent, consisting of all non-proteinogenic amino acids, such as N-methylpyrrole (Py), N-methylimidazole (Im), β-Alanine (βAla) and γ-aminobutyric acid (γAbu).
PIPA can bind to specific nucleotide sequences in the minor groove of double-helical DNA with high affinity and specificity, suggesting that PIPA blocks binding of transcription factors inhibiting gene expression, thus PIPA can be used for gene-control.

Features

  • Alternative gene silencer other than siRNA or PNA
  • Stable in cells or bodies because of nuclease resistance
  • Specifically binds to the target double strand DNA
  • Flexible Design against any gene
  • No-toxicities have been found in animal experiments
  • Form : Freeze dried powder
  • No additives
Code Structure (C-terminal amide) Mol. Weight Target Gene Reference
HPTB01 Ac-Im-Py-Py-βAla-Im-Py-Py-gAbu-PyPy-Py-βAla-Py-Py-βAla-Dp 1787.9 Human TGF-β1 1
HPTB02 Ac-Im-Im-βAla-Im-Py-Im-gAbu-Py-Py-Py-βAla-Py-Py-βAla-Dp 1667.75 Human TGF-β1 1
HPTB03 Ac-Im-Py-Im-βAla-Py-Py-Py-gAbu-Im-Py-Im-βAla-Py-Py-Py-βAla-Dp 1912 Human TGF-β1 1
HPTB04 Ac-Py-Py-βAla-Py-Im-Py-gAbu-Py-Py-Py-βAla-Im-Py-βAla-Dp 1665.78 Rat TGF-β1 2
HPLH05 Ac-Im-Py-Im-βAla-Py-Py-Im-gAbu-Py-Py-Py-βAla-Py-Py-Py-βAla-Dp 1911.01 Human LOX-1 3
HPLR06 Ac-Py-Py-βAla-Py-Py-Im-gAbu-Py-Im-Im-βAla-Py-Im-βAla-Dp 1667.75 Rat LOX-1 4
HPCT07 Ac-Im-Py-Py-βAla-Py-Py-Py-gAbu-Im-Py-Im-βAla-Im-Py-Py-βAla-Dp 1912 Human CTGF 5
HPTE08 Ac-Py-Im-βAla-Im-Im-Im-gAbu-Im-Py-Py-βAla-Py-Py-βAla-Dp 1668.74 TMPRSS2-ERG 6*
HPTE09 Ac-Py-Im-βAla-Im-Im-Im-gAbu-Py-Py-Py-βAla-Py-Py-βAla-Dp 1667.75 TMPRSS2-ERG 6*

* Published patent

Go back to index

Reference

  1. Igarashi, J. et. al., PLoS One. 2015,10, e0125295.
  2. Matsuda, H. et. al., Kidney Int. 2011, 79, 46-56.
  3. Kamei, T. et. al., J. Biomed. Biotechnol., 2012, 2102:715928.
  4. Yao, E. H. et. al., Hypertension, 2008, 52, 86-92.
  5. Wan, J. X.et. al., Biol. Pharm. Bull. 2011, 34, 1572-1577.
  6. Obinata, D. et. al., Cancer Sci., 2014, 105, 1272-1278.
  7. P. B. Dervan et. al., Nature (1998) 391 468-471
  8. P. B. Dervan and R. W. Burli, Current Opinion in Chemical Biology 3 (1999) 688-693
  9. P. B. Dervan, Bioorganic & Medicinal Chemistry 9 (2001) 2215-2235.

[Date : February 15 2024 12:37]

Detail Product Name Product Code Supplier Size Price
PIPA for Human TGF-β1
HPTB01 HPL 100 µg -

Description
Storage CAS
Link

PIPA for Human TGF-β1
HPTB01 HPL 1 mg -

Description
Storage CAS
Link

PIPA for Human TGF-β1
HPTB02 HPL 100 µg -

Description
Storage CAS
Link

PIPA for Human TGF-β1
HPTB02 HPL 1 mg -

Description
Storage CAS
Link

PIPA for Human TGF-β1
HPTB03 HPL 100 µg -

Description
Storage CAS
Link

PIPA for Human TGF-β1
 HPTB03 HPL 1 mg -

Description
Storage CAS
Link

PIPA for Rat TGF-β1
 HPTB04 HPL 100 µg -

Description Ac-Py-Py-βAla-Py-Im-Py-gAbu-Py-Py-Py-βAla-Im-Py-βAla-Dp
Storage CAS
Link

PIPA for Rat TGF-β1
HPTB04 HPL 1 mg -

Description Ac-Py-Py-βAla-Py-Im-Py-gAbu-Py-Py-Py-βAla-Im-Py-βAla-Dp
Storage CAS
Link

PIPA for Human LOX-1
HPLH05 HPL 100 µg -

Description Ac-Im-Py-Im-βAla-Py-Py-Im-gAbu-Py-Py-Py-βAla-Py-Py-Py-βAla-Dp
Storage CAS
Link

PIPA for Human LOX-1
HPLH05 HPL 1 mg -

Description Ac-Im-Py-Im-βAla-Py-Py-Im-gAbu-Py-Py-Py-βAla-Py-Py-Py-βAla-Dp
Storage CAS
Link

PIPA for Rat LOX-1
 HPLR06 HPL 100 µg -

Description Ac-Py-Py-βAla-Py-Py-Im-gAbu-Py-Im-Im-βAla-Py-Im-βAla-Dp
Storage CAS
Link

PIPA for Rat LOX-1
HPLR06 HPL 1 mg -

Description Ac-Py-Py-βAla-Py-Py-Im-gAbu-Py-Im-Im-βAla-Py-Im-βAla-Dp
Storage CAS
Link

PIPA for Human CTGF
HPCT07 HPL 100 µg -

Description Ac-Im-Py-Py-βAla-Py-Py-Py-gAbu-Im-Py-Im-βAla-Im-Py-Py-βAla-Dp
Storage CAS
Link

PIPA for Human CTGF
 HPCT07 HPL 1 mg -

Description Ac-Im-Py-Py-βAla-Py-Py-Py-gAbu-Im-Py-Im-βAla-Im-Py-Py-βAla-Dp
Storage CAS
Link

PIPA for TMPRSS2-ERG
 HPTE08 HPL 100 µg -

Description Ac-Py-Im-βAla-Im-Im-Im-gAbu-Im-Py-Py-βAla-Py-Py-βAla-Dp
Storage CAS
Link

PIPA for TMPRSS2-ERG
 HPTE08 HPL 1 mg -

Description Ac-Py-Im-βAla-Im-Im-Im-gAbu-Im-Py-Py-βAla-Py-Py-βAla-Dp
Storage CAS
Link

[Date : February 15 2024 12:37]

PIPA for Human TGF-β1


  • Product Code: HPTB01
  • Supplier: HPL
  • Size: 100µg
  • Price: -

Description
Storage CAS
Link

PIPA for Human TGF-β1


  • Product Code: HPTB01
  • Supplier: HPL
  • Size: 1mg
  • Price: -

Description
Storage CAS
Link

PIPA for Human TGF-β1


  • Product Code: HPTB02
  • Supplier: HPL
  • Size: 100µg
  • Price: -

Description
Storage CAS
Link

PIPA for Human TGF-β1


  • Product Code: HPTB02
  • Supplier: HPL
  • Size: 1mg
  • Price: -

Description
Storage CAS
Link

PIPA for Human TGF-β1


  • Product Code: HPTB03
  • Supplier: HPL
  • Size: 100µg
  • Price: -

Description
Storage CAS
Link

PIPA for Human TGF-β1


  • Product Code: HPTB03
  • Supplier: HPL
  • Size: 1mg
  • Price: -

Description
Storage CAS
Link

PIPA for Rat TGF-β1


  • Product Code: HPTB04
  • Supplier: HPL
  • Size: 100µg
  • Price: -

Description Ac-Py-Py-βAla-Py-Im-Py-gAbu-Py-Py-Py-βAla-Im-Py-βAla-Dp
Storage CAS
Link

PIPA for Rat TGF-β1


  • Product Code: HPTB04
  • Supplier: HPL
  • Size: 1mg
  • Price: -

Description Ac-Py-Py-βAla-Py-Im-Py-gAbu-Py-Py-Py-βAla-Im-Py-βAla-Dp
Storage CAS
Link

PIPA for Human LOX-1


  • Product Code: HPLH05
  • Supplier: HPL
  • Size: 100µg
  • Price: -

Description Ac-Im-Py-Im-βAla-Py-Py-Im-gAbu-Py-Py-Py-βAla-Py-Py-Py-βAla-Dp
Storage CAS
Link

PIPA for Human LOX-1


  • Product Code: HPLH05
  • Supplier: HPL
  • Size: 1mg
  • Price: -

Description Ac-Im-Py-Im-βAla-Py-Py-Im-gAbu-Py-Py-Py-βAla-Py-Py-Py-βAla-Dp
Storage CAS
Link

PIPA for Rat LOX-1


  • Product Code: HPLR06
  • Supplier: HPL
  • Size: 100µg
  • Price: -

Description Ac-Py-Py-βAla-Py-Py-Im-gAbu-Py-Im-Im-βAla-Py-Im-βAla-Dp
Storage CAS
Link

PIPA for Rat LOX-1


  • Product Code: HPLR06
  • Supplier: HPL
  • Size: 1mg
  • Price: -

Description Ac-Py-Py-βAla-Py-Py-Im-gAbu-Py-Im-Im-βAla-Py-Im-βAla-Dp
Storage CAS
Link

PIPA for Human CTGF


  • Product Code: HPCT07
  • Supplier: HPL
  • Size: 100µg
  • Price: -

Description Ac-Im-Py-Py-βAla-Py-Py-Py-gAbu-Im-Py-Im-βAla-Im-Py-Py-βAla-Dp
Storage CAS
Link

PIPA for Human CTGF


  • Product Code: HPCT07
  • Supplier: HPL
  • Size: 1mg
  • Price: -

Description Ac-Im-Py-Py-βAla-Py-Py-Py-gAbu-Im-Py-Im-βAla-Im-Py-Py-βAla-Dp
Storage CAS
Link

PIPA for TMPRSS2-ERG


  • Product Code: HPTE08
  • Supplier: HPL
  • Size: 100µg
  • Price: -

Description Ac-Py-Im-βAla-Im-Im-Im-gAbu-Im-Py-Py-βAla-Py-Py-βAla-Dp
Storage CAS
Link

PIPA for TMPRSS2-ERG


  • Product Code: HPTE08
  • Supplier: HPL
  • Size: 1mg
  • Price: -

Description Ac-Py-Im-βAla-Im-Im-Im-gAbu-Im-Py-Py-βAla-Py-Py-βAla-Dp
Storage CAS
Link

Go back to index

CONTACT

export@funakoshi.co.jp

  • ※Prices are for USA / Canada customers. Prices do not include shipping and handling charges, VAT, import tariffs and service charge etc.
  • ※Please note that Product Information or Price may change without notice.