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Gene Control Reagent : PIPA

Date:February 16 2017Web Page No:80767

Alternative gene silencer other than siRNA or PNA
PIPA (Py-Im-Polyamide)

PIPA (Py-Im-Polyamide)

PIPA (Py-Im-Polyamide) is a gene expression control reagent, consisting of all non-proteinogenic amino acids, such as N-methylpyrrole (Py), N-methylimidazole (Im), β-Alanine (βAla) and γ-aminobutyric acid (γAbu).
PIPA can bind to specific nucleotide sequences in the minor groove of double-helical DNA with high affinity and specificity, suggesting that PIPA blocks binding of transcription factors inhibiting gene expression, thus PIPA can be used for gene-control.

Features

  • Alternative gene silencer other than siRNA or PNA
  • Stable in cells or bodies because of nuclease resistance
  • Specifically binds to the target double strand DNA
  • Flexible Design against any gene
  • No-toxicities have been found in animal experiments
  • Form : Freeze dried powder
  • No additives
Code Structure (C-terminal amide) Mol. Weight Target Gene Reference
HPTB01 Ac-Im-Py-Py-βAla-Im-Py-Py-gAbu-PyPy-Py-βAla-Py-Py-βAla-Dp 1787.9 Human TGF-β1 1
HPTB02 Ac-Im-Im-βAla-Im-Py-Im-gAbu-Py-Py-Py-βAla-Py-Py-βAla-Dp 1667.75 Human TGF-β1 1
HPTB03 Ac-Im-Py-Im-βAla-Py-Py-Py-gAbu-Im-Py-Im-βAla-Py-Py-Py-βAla-Dp 1912 Human TGF-β1 1
HPTB04 Ac-Py-Py-βAla-Py-Im-Py-gAbu-Py-Py-Py-βAla-Im-Py-βAla-Dp 1665.78 Rat TGF-β1 2
HPLH05 Ac-Im-Py-Im-βAla-Py-Py-Im-gAbu-Py-Py-Py-βAla-Py-Py-Py-βAla-Dp 1911.01 Human LOX-1 3
HPLR06 Ac-Py-Py-βAla-Py-Py-Im-gAbu-Py-Im-Im-βAla-Py-Im-βAla-Dp 1667.75 Rat LOX-1 4
HPCT07 Ac-Im-Py-Py-βAla-Py-Py-Py-gAbu-Im-Py-Im-βAla-Im-Py-Py-βAla-Dp 1912 Human CTGF 5
HPTE08 Ac-Py-Im-βAla-Im-Im-Im-gAbu-Im-Py-Py-βAla-Py-Py-βAla-Dp 1668.74 TMPRSS2-ERG 6*
HPTE09 Ac-Py-Im-βAla-Im-Im-Im-gAbu-Py-Py-Py-βAla-Py-Py-βAla-Dp 1667.75 TMPRSS2-ERG 6*

* Published patent

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Reference

[Date : October 20 2018 00:14]

Detail Product Name Product Code Supplier Size Price
PIPA for Human TGF-β1
HPTB01 HPL 100 µg $1,350

Description
Storage CAS
Link

PIPA for Human TGF-β1
HPTB01 HPL 1 mg $3,350

Description
Storage CAS
Link

PIPA for Human TGF-β1
HPTB02 HPL 100 µg $1,650

Description
Storage CAS
Link

PIPA for Human TGF-β1
HPTB02 HPL 1 mg $4,100

Description
Storage CAS
Link

PIPA for Human TGF-β1
HPTB03 HPL 100 µg $2,050

Description
Storage CAS
Link

PIPA for Human TGF-β1
HPTB03 HPL 1 mg $5,500

Description
Storage CAS
Link

PIPA for Rat TGF-β1
HPTB04 HPL 100 µg $1,650

Description Ac-Py-Py-βAla-Py-Im-Py-gAbu-Py-Py-Py-βAla-Im-Py-βAla-Dp
Storage CAS
Link

PIPA for Rat TGF-β1
HPTB04 HPL 1 mg $4,100

Description Ac-Py-Py-βAla-Py-Im-Py-gAbu-Py-Py-Py-βAla-Im-Py-βAla-Dp
Storage CAS
Link

PIPA for Human LOX-1
HPLH05 HPL 100 µg $2,050

Description Ac-Im-Py-Im-βAla-Py-Py-Im-gAbu-Py-Py-Py-βAla-Py-Py-Py-βAla-Dp
Storage CAS
Link

PIPA for Human LOX-1
HPLH05 HPL 1 mg $5,500

Description Ac-Im-Py-Im-βAla-Py-Py-Im-gAbu-Py-Py-Py-βAla-Py-Py-Py-βAla-Dp
Storage CAS
Link

PIPA for Rat LOX-1
HPLR06 HPL 100 µg $2,750

Description Ac-Py-Py-βAla-Py-Py-Im-gAbu-Py-Im-Im-βAla-Py-Im-βAla-Dp
Storage CAS
Link

PIPA for Rat LOX-1
HPLR06 HPL 1 mg $6,800

Description Ac-Py-Py-βAla-Py-Py-Im-gAbu-Py-Im-Im-βAla-Py-Im-βAla-Dp
Storage CAS
Link

PIPA for Human CTGF
HPCT07 HPL 100 µg $1,650

Description Ac-Im-Py-Py-βAla-Py-Py-Py-gAbu-Im-Py-Im-βAla-Im-Py-Py-βAla-Dp
Storage CAS
Link

PIPA for Human CTGF
HPCT07 HPL 1 mg $4,100

Description Ac-Im-Py-Py-βAla-Py-Py-Py-gAbu-Im-Py-Im-βAla-Im-Py-Py-βAla-Dp
Storage CAS
Link

PIPA for TMPRSS2-ERG
HPTE08 HPL 100 µg $1,650

Description Ac-Py-Im-βAla-Im-Im-Im-gAbu-Im-Py-Py-βAla-Py-Py-βAla-Dp
Storage CAS
Link

PIPA for TMPRSS2-ERG
HPTE08 HPL 1 mg $4,100

Description Ac-Py-Im-βAla-Im-Im-Im-gAbu-Im-Py-Py-βAla-Py-Py-βAla-Dp
Storage CAS
Link

PIPA for TMPRSS2-ERG
HPTE09 HPL 100 µg $1,650

Description Ac-Py-Im-βAla-Im-Im-Im-gAbu-Py-Py-Py-βAla-Py-Py-βAla-Dp
Storage CAS
Link

PIPA for TMPRSS2-ERG
HPTE09 HPL 1 mg $4,100

Description Ac-Py-Im-βAla-Im-Im-Im-gAbu-Py-Py-Py-βAla-Py-Py-βAla-Dp
Storage CAS
Link

[Date : October 20 2018 00:14]

PIPA for Human TGF-β1


  • Product Code: HPTB01
  • Supplier: HPL
  • Size: 100µg
  • Price: $1,350

Description
Storage CAS
Link

PIPA for Human TGF-β1


  • Product Code: HPTB01
  • Supplier: HPL
  • Size: 1mg
  • Price: $3,350

Description
Storage CAS
Link

PIPA for Human TGF-β1


  • Product Code: HPTB02
  • Supplier: HPL
  • Size: 100µg
  • Price: $1,650

Description
Storage CAS
Link

PIPA for Human TGF-β1


  • Product Code: HPTB02
  • Supplier: HPL
  • Size: 1mg
  • Price: $4,100

Description
Storage CAS
Link

PIPA for Human TGF-β1


  • Product Code: HPTB03
  • Supplier: HPL
  • Size: 100µg
  • Price: $2,050

Description
Storage CAS
Link

PIPA for Human TGF-β1


  • Product Code: HPTB03
  • Supplier: HPL
  • Size: 1mg
  • Price: $5,500

Description
Storage CAS
Link

PIPA for Rat TGF-β1


  • Product Code: HPTB04
  • Supplier: HPL
  • Size: 100µg
  • Price: $1,650

Description Ac-Py-Py-βAla-Py-Im-Py-gAbu-Py-Py-Py-βAla-Im-Py-βAla-Dp
Storage CAS
Link

PIPA for Rat TGF-β1


  • Product Code: HPTB04
  • Supplier: HPL
  • Size: 1mg
  • Price: $4,100

Description Ac-Py-Py-βAla-Py-Im-Py-gAbu-Py-Py-Py-βAla-Im-Py-βAla-Dp
Storage CAS
Link

PIPA for Human LOX-1


  • Product Code: HPLH05
  • Supplier: HPL
  • Size: 100µg
  • Price: $2,050

Description Ac-Im-Py-Im-βAla-Py-Py-Im-gAbu-Py-Py-Py-βAla-Py-Py-Py-βAla-Dp
Storage CAS
Link

PIPA for Human LOX-1


  • Product Code: HPLH05
  • Supplier: HPL
  • Size: 1mg
  • Price: $5,500

Description Ac-Im-Py-Im-βAla-Py-Py-Im-gAbu-Py-Py-Py-βAla-Py-Py-Py-βAla-Dp
Storage CAS
Link

PIPA for Rat LOX-1


  • Product Code: HPLR06
  • Supplier: HPL
  • Size: 100µg
  • Price: $2,750

Description Ac-Py-Py-βAla-Py-Py-Im-gAbu-Py-Im-Im-βAla-Py-Im-βAla-Dp
Storage CAS
Link

PIPA for Rat LOX-1


  • Product Code: HPLR06
  • Supplier: HPL
  • Size: 1mg
  • Price: $6,800

Description Ac-Py-Py-βAla-Py-Py-Im-gAbu-Py-Im-Im-βAla-Py-Im-βAla-Dp
Storage CAS
Link

PIPA for Human CTGF


  • Product Code: HPCT07
  • Supplier: HPL
  • Size: 100µg
  • Price: $1,650

Description Ac-Im-Py-Py-βAla-Py-Py-Py-gAbu-Im-Py-Im-βAla-Im-Py-Py-βAla-Dp
Storage CAS
Link

PIPA for Human CTGF


  • Product Code: HPCT07
  • Supplier: HPL
  • Size: 1mg
  • Price: $4,100

Description Ac-Im-Py-Py-βAla-Py-Py-Py-gAbu-Im-Py-Im-βAla-Im-Py-Py-βAla-Dp
Storage CAS
Link

PIPA for TMPRSS2-ERG


  • Product Code: HPTE08
  • Supplier: HPL
  • Size: 100µg
  • Price: $1,650

Description Ac-Py-Im-βAla-Im-Im-Im-gAbu-Im-Py-Py-βAla-Py-Py-βAla-Dp
Storage CAS
Link

PIPA for TMPRSS2-ERG


  • Product Code: HPTE08
  • Supplier: HPL
  • Size: 1mg
  • Price: $4,100

Description Ac-Py-Im-βAla-Im-Im-Im-gAbu-Im-Py-Py-βAla-Py-Py-βAla-Dp
Storage CAS
Link

PIPA for TMPRSS2-ERG


  • Product Code: HPTE09
  • Supplier: HPL
  • Size: 100µg
  • Price: $1,650

Description Ac-Py-Im-βAla-Im-Im-Im-gAbu-Py-Py-Py-βAla-Py-Py-βAla-Dp
Storage CAS
Link

PIPA for TMPRSS2-ERG


  • Product Code: HPTE09
  • Supplier: HPL
  • Size: 1mg
  • Price: $4,100

Description Ac-Py-Im-βAla-Im-Im-Im-gAbu-Py-Py-Py-βAla-Py-Py-βAla-Dp
Storage CAS
Link

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