New mitochondria uncoupling agent Ppc-1 | Funakoshi
Date：December 22 2017Web Page No：80714
Funakoshi Co.,Ltd.
Increasing mitochondria's oxigen consumption without inhibiting ATP synthesis
Ppc-1, MitoUncoupler
Ppc-1 is a newly isolated molecule from Polysphondylium pseudo-candidum.
It shows comparatively mild uncoupling activity in Mitochodria.
According to papers, following effects are reported in Ppc-1.
- Ppc-1 stimulates oxygen consumption without inhibiting ATP synthesis in mitochondria, isolated from mouse liver. 1), 2)
- Ppc-1 administrated mouse shows inhibition of weight gain, without affecting liver and kidney. 1), 2)
- Cell proliferation is inhibited without inducing cell death, in Ppc-1 treated 3T3-L1 cells. 3)
Features
- Comparatively mild uncoupling activity.
- Low effect on ATP synthesis or degradation.
- Low active oxygen generation.
- Low cytotoxicity.
- Cell proliferation is inhibited by adding Ppc-1 to culture medium.
- Chemical Name ：3-Methylbut-2-enyl 4-methoxy-8-(3-methylbut-2-enyloxy)quinoline-2-carboxylate
- CAS number ：1245818-17-0
- Molecular Formula ：C21H25NO4
- Molecular Weight ：355.43
- Purity ：≧98%
- Soluble in DMSO
Reference
1) Suzuki T, et. al, PLoS One. 2015 Feb10; 10(2):e0117088.
2) Kikuchi H, et. al, Bioorg Med Chem., 23(1): 66-72(2015).
3) Kikuchi H, et. al, Tetrahedron, 66: 6000-6007(2010).
[Date : April 25 2025 00:06]
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Ppc-1, MitoUncoupler DatasheetThis may not be the latest data sheet. |
FDV-0011 | FNAFunakoshi Co.,Ltd. | 5 mg | $300 | |||||||||||||||||||||||||||||||
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[Date : April 25 2025 00:06]
Ppc-1, MitoUncoupler
DatasheetThis may not be the latest data sheet.
- Product Code: FDV-0011
- Supplier: FNA
- Size: 5mg
- Price: $300
| Description |
Ppc-1 is a newly isolated molecule from Polysphondylium pseudo-candidum. It shows comparatively mild uncoupling activity in Mitochodria. |
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| Storage | -20°C | CAS | 1245818-17-0 |
| Link |
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