For amyotrophic lateral sclerosis (ALS) research Anti-Asymmetric Dimethylarginine of TLS/FUS Antibody
Date：February 24 2016Web Page No：80107
Funakoshi Co.,Ltd.
A mouse monoclonal antibody that specifically recognizes asymmetric dimethylated arginine (R216, R218) in TLS/FUS (Translocated in LipoSarcoma / Fused in Sarcoma). It does not cross unmethylated TLS/FUS or symmetrically dimethylated TLS/FUS. TLS/FUS is said to be one of the causative genes of amyotrophic lateral sclerosis (ALS).
About Asymmetric Dimethylarginine of TLS/FUS
Arginine methylation is one of posttranslational modifications, catalyzed by Protein Arginine Methyltransferases : PRMT. Arginine is known to be methylated once (monomethylated arginine) or twice (dimethylated arginine). Dimethylation can be further categorized asymmetric (me2s) or asymmetric (me2a).
Features
- This antibody can detect asymmetric dimethylarginine (R216, R218) of TLS/FUS specifically by westernblot in sample which is immunoprecipitated by Bethyl laboratories' anti-FUS antibody (A300-302A)*.
- Immunoprecipitation of samples with this antibody allows the function of methylation of TLS/FUS to be analyzed by RNA-binding protein immunoprecipitation.
*Since it is difficult to specifically detect dimethylated TLS/FUS in cell lysate samples by Western blotting, it is recommended to perform immunoprecipitation with anti-TLS/FUS polyclonal antibody beforehand.
Reference
- Fujimoto, K., and Kurokawa R., "Development of a mouse monoclonal antibody for the detection of asymmetric dimethylarginine of Translocated in LipoSarcoma/FUsed in Sarcoma and its application in analyzing methylated TLS", Cell Biosci., 4, 77 (2014). [PMID:25810899]
- Jun, M.H., et al., "Sequestration of PRMT1 and Nd1-L mRNA into ALS-linked FUS mutant R521C-positive aggregates contributes to neurite degeneration upon oxidative stress", Sci. Rep., 7, 40474 (2017). [PMID:28094300]
[Date : April 26 2025 00:07]
| Detail | Product Name | Product Code | Supplier | Size | Price | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Anti-Asymmetric Dimethylarginine of TLS/FUS (R216, R218), Human, Mouse-Mono DatasheetThis may not be the latest data sheet. |
FDV-0006 | FNAFunakoshi Co.,Ltd. | 25 µg | $120 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
Anti-Asymmetric Dimethylarginine of TLS/FUS (R216, R218), Human, Mouse-Mono DatasheetThis may not be the latest data sheet. |
FDV-0007 | FNAFunakoshi Co.,Ltd. | 100 µg | $400 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
[Date : April 26 2025 00:07]
Anti-Asymmetric Dimethylarginine of TLS/FUS (R216, R218), Human, Mouse-Mono
DatasheetThis may not be the latest data sheet.
- Product Code: FDV-0006
- Supplier: FNA
- Size: 25µg
- Price: $120
| Description |
This antibody recognizes asymmetric dimethylarginine (R216, R218) of TLS/FUS. It does not cross-reacts against symmetric dimethylarginine of TLS/FUS, and non -methylated TLS /FUS. TLS: Translocated in LipoSarcoma FUS: Fused in Sarcoma |
||
|---|---|---|---|
| Storage | -20°C | ||
| Antigen Species | Host Species | Mouse | |
| Class | IgG | Label | Unlabeled |
| Cross Reactivity | Human/Hamster/Mouse | Application | IP,Western Blot |
| Clonality | Format | ||
| Purification | Protein A/G Affinity Purified | Absorption | |
| Link |
|
||
Anti-Asymmetric Dimethylarginine of TLS/FUS (R216, R218), Human, Mouse-Mono
DatasheetThis may not be the latest data sheet.
- Product Code: FDV-0007
- Supplier: FNA
- Size: 100µg
- Price: $400
| Description |
This antibody recognizes asymmetric dimethylarginine (R216, R218) of TLS/FUS. It does not cross-reacts against symmetric dimethylarginine of TLS/FUS, and non -methylated TLS /FUS. TLS: Translocated in LipoSarcoma FUS: Fused in Sarcoma |
||
|---|---|---|---|
| Storage | -20°C | ||
| Antigen Species | Host Species | Mouse | |
| Class | IgG | Label | Unlabeled |
| Cross Reactivity | Human/Hamster/Mouse | Application | IP,Western Blot |
| Clonality | Format | ||
| Purification | Protein A/G Affinity Purified | Absorption | |
| Link |
|
||
CONTACT
export@funakoshi.co.jp
- ※Prices on our website are for your reference only. Please inquire your distributor for your prices.
- ※Please note that Product Information or Price may change without notice.