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Anti-Asymmetric Dimethylarginine of TLS/FUS Antibody

Date：February 24 2016Web Page No：80107

Funakoshi Co.,Ltd.

Antibody specific to asymmetric dimethylarginine (R216, R218) of TLS/FUS

WB picture using asymmetric dimethylarginine (R216, R218) of TLS/FUS

WB picture using asymmetric dimethylarginine (R216, R218) of TLS/FUS

  • Lane1: Recombinant GST-TLS/FUS methylated using PRMT1 in the presence of SAM (20 mM)
  • Lane2: Cell extract from CHO cells immunoprecipitated with rabbit polyclonal anti-TLS/FUS antibody (Bethyl Laboratories, #A300-302A).

About Asymmetric Dimethylarginine of TLS/FUS

Arginine methylation is one of posttranslational modifications, catalyzed by Protein Arginine Methyltransferases : PRMT. Arginine is known to be methylated once (monomethylated arginine) or twice (dimethylated arginine). Dimethylation can be further categorized asymmetric (me2s) or asymmetric (me2a).

TLS/FUS (Translocated in LipoSarcoma/Fused in Sarcoma) is known as one of causative genes for familial amyotrophic lateral sclerosis (ALS). Especially, it is reported that four arginine residues in TLS/FUS (R216, R218, R242, and R394) are constitutively dimethylated by protein arginine methyltransferases.
It is also reported that TLS/FUS binds to lncRNAs transcripted from cyclin D1 promotor. However, the function of methylated TLS/FUS is still unclear. This antibody recognizes asymmetric dimethylarginine (R216, R218) of TLS/FUS. It does not cross-react against symmetric dimethylarginine of TLS/FUS, and non -methylated TLS /FUS.

メチル化アルギニンの種類


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Features

  • This antibody can detect asymmetric dimethylarginine (R216, R218) of TLS/FUS specifically by westernblot in the sample which is immunoprecipitated by Bethyl laboratories' Anti-FUS antibody (#A300-302A).

* It is highly recommended that cell lysate sample should be immunoprecipitated by using #A300-302A prior to western blotting.

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Specifications

  • Host: Mouse
  • Clone No: 2B12

  • Specificity: This antibody recognizes asymmetric dimethylarginine (R216, R218) of TLS/FUS.
    This antibody does not cross-reacts against symmetric dimethylarginine of TLS/FUS, and non-methylated TLS/FUS.

  • Subclass: IgG
  • Storage Buffer: Phosphate buffered saline, pH7.2, no preservative added
  • Purification: Protein G Purified
  • Concentration: 0.5 mg/ml
  • Cross Reactivity: Human, Mouse, Hamster (CHO cell) – Not yet tested in other species.
  • Immunogen: Synthetic CGGRme2aGRme2aGGSG
  • Application: WB (1:500 – 1:2000), IP
  • Storage: Store below -20℃. Avoid repeated freeze-thaw cycles.

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Reference

[Date : July 27 2024 00:10]

Detail Product Name Product Code Supplier Size Price
Anti-Asymmetric Dimethylarginine of TLS/FUS (R216, R218), Human, Mouse-Mono
DatasheetThis may not be the latest data sheet. 		FDV-0006 FNAFunakoshi Co.,Ltd. 25 µg $120

Description This antibody recognizes asymmetric dimethylarginine (R216, R218) of TLS/FUS. It does not cross-reacts against symmetric dimethylarginine of TLS/FUS, and non -methylated TLS /FUS. TLS: Translocated in LipoSarcoma FUS: Fused in Sarcoma
Storage -20°C
Antigen Species Host Species Mouse Class IgG Label Unlabeled
Cross Reactivity Human/Hamster/Mouse Application IP,Western Blot
Clonality Format Purification Protein A/G Affinity Purified Absorption
Link

Anti-Asymmetric Dimethylarginine of TLS/FUS (R216, R218), Human, Mouse-Mono
DatasheetThis may not be the latest data sheet. 		FDV-0007 FNAFunakoshi Co.,Ltd. 100 µg $400

Description This antibody recognizes asymmetric dimethylarginine (R216, R218) of TLS/FUS. It does not cross-reacts against symmetric dimethylarginine of TLS/FUS, and non -methylated TLS /FUS. TLS: Translocated in LipoSarcoma FUS: Fused in Sarcoma
Storage -20°C
Antigen Species Host Species Mouse Class IgG Label Unlabeled
Cross Reactivity Human/Hamster/Mouse Application IP,Western Blot
Clonality Format Purification Protein A/G Affinity Purified Absorption
Link

[Date : July 27 2024 00:10]

Anti-Asymmetric Dimethylarginine of TLS/FUS (R216, R218), Human, Mouse-Mono

DatasheetThis may not be the latest data sheet.


  • Product Code: FDV-0006
  • Supplier: FNA
  • Size: 25µg
  • Price: $120

Description This antibody recognizes asymmetric dimethylarginine (R216, R218) of TLS/FUS. It does not cross-reacts against symmetric dimethylarginine of TLS/FUS, and non -methylated TLS /FUS. TLS: Translocated in LipoSarcoma FUS: Fused in Sarcoma
Storage -20°C
Antigen Species Host Species Mouse
Class IgG Label Unlabeled
Cross Reactivity Human/Hamster/Mouse Application IP,Western Blot
Clonality Format
Purification Protein A/G Affinity Purified Absorption
Link

Anti-Asymmetric Dimethylarginine of TLS/FUS (R216, R218), Human, Mouse-Mono

DatasheetThis may not be the latest data sheet.


  • Product Code: FDV-0007
  • Supplier: FNA
  • Size: 100µg
  • Price: $400

Description This antibody recognizes asymmetric dimethylarginine (R216, R218) of TLS/FUS. It does not cross-reacts against symmetric dimethylarginine of TLS/FUS, and non -methylated TLS /FUS. TLS: Translocated in LipoSarcoma FUS: Fused in Sarcoma
Storage -20°C
Antigen Species Host Species Mouse
Class IgG Label Unlabeled
Cross Reactivity Human/Hamster/Mouse Application IP,Western Blot
Clonality Format
Purification Protein A/G Affinity Purified Absorption
Link

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