Macrophage depletion reagent Clodronate liposome
Date：August 05 2026Web Page No：718221
This product is a clodronate-incapsulated liposome reagent. Clodronate itself is known to be difficult to pass through a cell membrane and to be incorporated by macrophage through phagocytosis. Clodronate liposome has efficient cell permeability, enhances macrophage phagocytosis, and can be used in macrophage depletion experiments.
What is clodronate?
Clodronate is a compound that depletes osteoclasts and inhibits bone absorption, and can be used in osteoporosis research. This compound is known to inhibit ATP metabolism as ATP analogue and to deplete not only osteoclasts but also macrophages.
In recent years, it has been reported that macrophages are associated with various diseases such as cancers, diabetes, and arteriosclerosis. To study relationship between such diseases and macrophages, it is necessary to temporarily deplete macrophages and observe changes of the state. Therefore, clodronate has recently been gaining attention as a useful tool to study these diseases.
- Features
- Specifications
- Application note
- Product citations
- Clodronate liposome
- Clodronate liposome (SMALL)
Features
- This product has lipid composition to be easily incorporated by macrophages and induces depletion of the cells temporally.
- This product is sterilized and tested that it is stable for two years from a production date checked by stability testing at 4 degrees.
- Two types of the products are available that one is a large particle type with 300nm diameter for targeting reticuloendothelial macrophages in liver, spleen etc., and the other is a small particle type with 100 nm diameter called SMALL for targeting tumor-associated macrophages.
- Internal data for administration route, dosage, and duration of effect of the products are available. In addition, many product citations are also available. (See Application note part below.)
- Internally used cell strains : Balb/c, C57BL/6J, C57BL/6, DBA/2, Balb/cA Jcl-nu/nu, and NOD/SCID/IL-2Rg null (NOG)
- Internally used model mice: Normal mice, gallbladder cancer model mice, and inflammation model mice
Specifications
| Product name | Lipid concentration (mg/ml) | Clodronate (mg/ml) | Average particle size (diameter, nm) | Zeta potential (mV) |
|---|---|---|---|---|
| Clodronate liposome | 45±20 | 10 | 280±50 | -70±20 |
| Clodronate liposome (SMALL) | 6.5 | 140±40 |
Application note
Induction of macrophage depletion in the liver and the spleen of normal mice
Normal mice were intraperitoneally administrated 200ul of the product. The liver and spleen were removed 24 hours later and expression levels of macrophage markers F4/80 and CD68 were checked by real-time PCR.
F4/80 and CD68: Macrophage marker genes
(The data were kindly offered by Dr. Yutaka Enomoto in Laboratory of Cell Growth and Differentiation Institute of Molecular and Cellular Biosciences, The University of Tokyo)
Immunostaining of macrophages in the liver and the spleen of normal mice
Normal mice were intraperitoneally administrated 200ul of the product. The liver and spleen were removed 24 hours later, and localization of macrophages was observed by tissue immunostaining.
(The data were kindly offered by Dr. Yutaka Enomoto in Laboratory of Cell Growth and Differentiation Institute of Molecular and Cellular Biosciences, The University of Tokyo)
Macrophage depletion effect in liver and spleen of gastric cancer model mice (1)
* The data were obtained by using Clodronate liposome (SMALL).
200ul of the product was administrated to tail vein of gastric cancer model mice. Tissue immunostaining of F4/80 was performed on the extracted liver and the spleen on day 3 or day 5 from the administration.
(The data were kindly offered by Dr. Masanobu Oshima in Division of Genetics, Cancer Research Institute, Kanazawa University.)
Macrophage depletion effect at the tumor site of gastric cancer model mice (2)
* The data were obtained by using Clodronate liposome (SMALL).
The tumor tissues of gastric cancer model mouse were extracted on the fifth day from tail vein administration. HE staining and immunostaining of F4/80 were performed on the extracted tissues.
(The data were kindly offered by Dr. Masanobu Oshima in Division of Genetics, Cancer Research Institute, Kanazawa University.)
Dose comparison of liposome based on the clodronate concentration
Mouse type: Normal Time: Day 1 from the administration
Organ type: Liver
Lasting effects of various doses
Mouse type: Normal Organ type: Liver
Comparison to competitor's product
Mouse type: Normal Administration route: Intraperitoneal administration
Organ extraction date: Day 1 from the administration Organ type: Liver
Product citations
- Product citations can be downloaded here.
Clodronate liposome
[Date : August 18 2026 00:09]
| Detail | Product Name | Product Code | Supplier | Size | Price | ||||||||||||||||||||||||||||||
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Clodronate liposome DatasheetThis may not be the latest data sheet. |
16001003 | HYG | 1 ml | $290 | |||||||||||||||||||||||||||||||
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Clodronate liposome DatasheetThis may not be the latest data sheet. |
16001004 | HYG | 2 ml | $497 | |||||||||||||||||||||||||||||||
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Clodronate liposome DatasheetThis may not be the latest data sheet. |
16001005 | HYG | 10 ml | $1,657 | |||||||||||||||||||||||||||||||
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Control for clodronate liposome DatasheetThis may not be the latest data sheet. |
16003631 | HYG | 1 ml | $141 | |||||||||||||||||||||||||||||||
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Control for clodronate liposome DatasheetThis may not be the latest data sheet. |
16003632 | HYG | 2 ml | $249 | |||||||||||||||||||||||||||||||
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Control for clodronate liposome DatasheetThis may not be the latest data sheet. |
16003633 | HYG | 10 ml | $828 | |||||||||||||||||||||||||||||||
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Clodronate liposome set product, 1ml each DatasheetThis may not be the latest data sheet. |
16003641 | HYG | 1 set | $331 | |||||||||||||||||||||||||||||||
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Clodronate liposome set product, 2ml each DatasheetThis may not be the latest data sheet. |
16003642 | HYG | 1 set | $580 | |||||||||||||||||||||||||||||||
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Clodronate liposome set product, 10ml each DatasheetThis may not be the latest data sheet. |
16003643 | HYG | 1 set | $1,947 | |||||||||||||||||||||||||||||||
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[Date : August 18 2026 00:09]
Clodronate liposome
DatasheetThis may not be the latest data sheet.
- Product Code: 16001003
- Supplier: HYG
- Size: 1ml
- Price: $290
| Description |
This product is clodronate which is encapsulated in liposome. This clodronate liposome has more efficient cell permeability than clodronate itself. The product is a useful tool for macrophage depletion experiments by enhancing macrophage phagocytosis and is a large particle type with 300nm diameter for targeting reticuloendothelial macrophages in liver, spleen etc. |
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|---|---|---|---|
| Storage | 4°C,Dark Storage | CAS | |
| Link |
|
||
Clodronate liposome
DatasheetThis may not be the latest data sheet.
- Product Code: 16001004
- Supplier: HYG
- Size: 2ml
- Price: $497
| Description |
This product is clodronate which is encapsulated in liposome. This clodronate liposome has more efficient cell permeability than clodronate itself. The product is a useful tool for macrophage depletion experiments by enhancing macrophage phagocytosis, and is a large particle type with 300nm diameter for targeting reticuloendothelial macrophages in liver, spleen etc. |
||
|---|---|---|---|
| Storage | 4°C,Dark Storage | CAS | |
| Link |
|
||
Clodronate liposome
DatasheetThis may not be the latest data sheet.
- Product Code: 16001005
- Supplier: HYG
- Size: 10ml
- Price: $1,657
| Description |
This product is clodronate which is encapsulated in liposome. This clodronate liposome has more efficient cell permeability than clodronate itself. The product is a useful tool for macrophage depletion experiments by enhancing macrophage phagocytosis. |
||
|---|---|---|---|
| Storage | 4°C,Dark Storage | CAS | |
| Link |
|
||
Control for clodronate liposome
DatasheetThis may not be the latest data sheet.
- Product Code: 16003631
- Supplier: HYG
- Size: 1ml
- Price: $141
| Description |
This product is empty and multilayer liposome which can be used as negative control for Clodronate liposome (#16001003, #16001004 and, #16001005) for macrophage depletion experiments. |
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|---|---|---|---|
| Storage | 4°C,Dark Storage | CAS | |
| Link |
|
||
Control for clodronate liposome
DatasheetThis may not be the latest data sheet.
- Product Code: 16003632
- Supplier: HYG
- Size: 2ml
- Price: $249
| Description |
This product is empty and multilayer liposome which can be used as negative control for Clodronate liposome (#16001003, #16001004 and, #16001005) for macrophage depletion experiments. |
||
|---|---|---|---|
| Storage | 4°C,Dark Storage | CAS | |
| Link |
|
||
Control for clodronate liposome
DatasheetThis may not be the latest data sheet.
- Product Code: 16003633
- Supplier: HYG
- Size: 10ml
- Price: $828
| Description |
This product is empty and multilayer liposome which can be used as negative control for Clodronate liposome (#16001003, #16001004 and, #16001005) for macrophage depletion experiments. |
||
|---|---|---|---|
| Storage | 4°C,Dark Storage | CAS | |
| Link |
|
||
Clodronate liposome set product, 1ml each
DatasheetThis may not be the latest data sheet.
- Product Code: 16003641
- Supplier: HYG
- Size: 1set
- Price: $331
| Description |
This product is a convenient kit which is a set of chlodronate liposome (#16001003) and empty liposome as negative control (#16003631) for macrophage depletion experiments. |
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|---|---|---|---|
| Storage | 4°C,Dark Storage | CAS | |
| Link |
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||
Clodronate liposome set product, 2ml each
DatasheetThis may not be the latest data sheet.
- Product Code: 16003642
- Supplier: HYG
- Size: 1set
- Price: $580
| Description |
A product consisting of a set of clodronate liposomes that deplete macrophages and corresponding control. |
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|---|---|---|---|
| Storage | 4°C,Dark Storage,Don't freeze | CAS | |
| Link |
|
||
Clodronate liposome set product, 10ml each
DatasheetThis may not be the latest data sheet.
- Product Code: 16003643
- Supplier: HYG
- Size: 1set
- Price: $1,947
| Description |
A product consisting of a set of clodronate liposomes that deplete macrophages and corresponding control. |
||
|---|---|---|---|
| Storage | 4°C,Dark Storage | CAS | |
| Link |
|
||
Clodronate liposome (SMALL)
[Date : August 18 2026 00:09]
| Detail | Product Name | Product Code | Supplier | Size | Price | ||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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Clodronate liposome (SMALL) |
16004461 | HYG | 1 ml | $290 | |||||||||||||||||||||||||||||||
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Clodronate liposome (SMALL) |
16004462 | HYG | 2 ml | $497 | |||||||||||||||||||||||||||||||
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Clodronate liposome (SMALL) |
16004463 | HYG | 10 ml | $1,657 | |||||||||||||||||||||||||||||||
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Control for clodronate liposome (SMALL) |
16004451 | HYG | 1 ml | $141 | |||||||||||||||||||||||||||||||
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Control for clodronate liposome (SMALL) |
16004452 | HYG | 2 ml | $249 | |||||||||||||||||||||||||||||||
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Control for clodronate liposome (SMALL) |
16004453 | HYG | 10 ml | $828 | |||||||||||||||||||||||||||||||
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|
|
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|
Clodronate liposome (SMALL) set product, 1ml each |
16004471 | HYG | 1 set | $331 | |||||||||||||||||||||||||||||||
|
|
|
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|
Clodronate liposome (SMALL) set product, 2ml each |
16004472 | HYG | 1 set | $580 | |||||||||||||||||||||||||||||||
|
|
|
||||||||||||||||||||||||||||||||||
|
Clodronate liposome (SMALL) set product, 10ml each |
16004473 | HYG | 1 set | $1,947 | |||||||||||||||||||||||||||||||
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[Date : August 18 2026 00:09]
Clodronate liposome (SMALL)
- Product Code: 16004461
- Supplier: HYG
- Size: 1ml
- Price: $290
| Description |
This product is clodronate which is encapsulated in liposome. This clodronate liposome has more efficient cell permeability than clodronate itself. The product is a useful tool for macrophage depletion experiments by enhancing macrophage phagocytosis and is a small particle type with 100 nm diameter called SMALL for targeting tumor-associated macrophages. |
||
|---|---|---|---|
| Storage | 4°C,Dark Storage | CAS | |
| Link |
|
||
Clodronate liposome (SMALL)
- Product Code: 16004462
- Supplier: HYG
- Size: 2ml
- Price: $497
| Description |
This product is clodronate which is encapsulated in liposome. This clodronate liposome has more efficient cell permeability than clodronate itself. The product is a useful tool for macrophage depletion experiments by enhancing macrophage phagocytosis and is a small particle type with 100 nm diameter called SMALL for targeting tumor-associated macrophages. |
||
|---|---|---|---|
| Storage | 4°C,Dark Storage | CAS | |
| Link |
|
||
Clodronate liposome (SMALL)
- Product Code: 16004463
- Supplier: HYG
- Size: 10ml
- Price: $1,657
| Description |
This product is clodronate which is encapsulated in liposome. This clodronate liposome has more efficient cell permeability than clodronate itself. The product is a useful tool for macrophage depletion experiments by enhancing macrophage phagocytosis and is a small particle type with 100 nm diameter called SMALL for targeting tumor-associated macrophages. |
||
|---|---|---|---|
| Storage | 4°C,Dark Storage | CAS | |
| Link |
|
||
Control for clodronate liposome (SMALL)
- Product Code: 16004451
- Supplier: HYG
- Size: 1ml
- Price: $141
| Description |
This product is empty and multilayer liposome which can be used as negative control for Clodronate liposome (SMALL) (#16004461, #16004462 and, #16004463) for macrophage depletion experiments. |
||
|---|---|---|---|
| Storage | 4°C,Dark Storage | CAS | |
| Link |
|
||
Control for clodronate liposome (SMALL)
- Product Code: 16004452
- Supplier: HYG
- Size: 2ml
- Price: $249
| Description |
This product is empty and multilayer liposome which can be used as negative control for Clodronate liposome (SMALL) (#16004461, #16004462 and, #16004463) for macrophage depletion experiments. |
||
|---|---|---|---|
| Storage | 4°C,Dark Storage | CAS | |
| Link |
|
||
Control for clodronate liposome (SMALL)
- Product Code: 16004453
- Supplier: HYG
- Size: 10ml
- Price: $828
| Description |
This product is empty and multilayer liposome which can be used as negative control for Clodronate liposome (SMALL) (#16004461, #16004462 and, #16004463) for macrophage depletion experiments. |
||
|---|---|---|---|
| Storage | 4°C,Dark Storage | CAS | |
| Link |
|
||
Clodronate liposome (SMALL) set product, 1ml each
- Product Code: 16004471
- Supplier: HYG
- Size: 1set
- Price: $331
| Description |
A product consisting of a set of clodronate liposomes (SMALL) that deplete macrophages and corresponding control. |
||
|---|---|---|---|
| Storage | 4°C,Dark Storage | CAS | |
| Link |
|
||
Clodronate liposome (SMALL) set product, 2ml each
- Product Code: 16004472
- Supplier: HYG
- Size: 1set
- Price: $580
| Description |
A product consisting of a set of clodronate liposomes (SMALL) that deplete macrophages and corresponding control. |
||
|---|---|---|---|
| Storage | 4°C,Dark Storage | CAS | |
| Link |
|
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