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HOME> Products> Natural and Chemical compound> Enzyme inhibitor> O-carbamyl-D-serine (OCDS)

Natural bioactive compound harboring bacterial cell wall synthesis and alanine racemase inhibitory activities O-carbamyl-D-serine (OCDS)

Date：July 30 2026Web Page No：718218

O-carbamyl-D-serine is an amino acid derivative which was isolated from the fermentation broth of Streptomyces sp. This natural bioactive compound is known as which is as D-alanine analogue indicates inhibitory activity to bacterial cell wall synthesis¹⁾ and alanine racemase inhibitory effect.²⁾
Furthermore, the combination of D-4-amino-3-isoxazolidone induced a synergistic antibacterial effect, indicating a 30% survival effect in mice in an intra-abdominal infection model of Staphylococcus aureus.³⁾

* This product is for research use only.
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Chemical Structure of O-Carbamyl-D-serine (OCDS) (#20324)

Specifications
Examples of physiological activities and effects
Reference
Product Information

Specifications

CAS#	3819-76-9
Molecular Formula	C₄H₈N₂O₄
Molecular Weight	148.118
Source	Streptomyces sp.
Purity	>98% (pNMR)
Long Term Storage	at -20˚C
Solubility	Soluble in H₂O Slightly soluble in MeOH

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Examples of physiological activities and effects

OCDS acted as a D-alanine derivative and inhibited peptidoglycan synthesis.¹⁾
The combination of OCDS and D-4-amino-3-isoxazolidone induced a synergistic antibacterial effect. The minimum inhibitory concentration (MIC) of OCDS was 100 ug/ml and that of D-4-amino-3-isoxazolidone was 10ug/ml. In addition, the MIC of OCDS in synthetic media was 1.25 ug/ml.³⁾
In an intra-abdominal infection model of Staphylococcus aureus in mice, 3 sets of hypodermic injections with 0.5g/kg of OCDS exhibited 30% survival rate after a week of the administration, which was approximately 3 times higher than the untreated control experiments.³⁾

* Biological activity of the product was not verified. The values shown above were cited from the references.

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Reference

Lynch, J.L. and Neuhaus, F.C., J. Bacteriol., 91(1), 449-460(1966). [PMID:4955253]
Azam, M.A. and Jayaram, U., J. Enzyme Inhib. Med. Chem., 31(4), 517-526(2016). [PMID:26024289]
Tanaka, N., et al., J. Antibiotics, 16(6), 217-221(1963). [PMID:14084116]

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Product Information

[Date : August 09 2026 00:07]

Detail Product Name Product Code Supplier Size Price

O-Carbamyl-D-serine <Inhibitor of bacterial cell wall synthesis>
DatasheetThis may not be the latest data sheet. 20324 IMCInstitute of Microbial Chemistry 10 mg $500

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Description	M.W.: 148.118 Purity : >98% (qNMR) Molecular Formula : C4H8N2O4 Solubility : Soluble in H2O, O-Carbamyl-D-serine which was isolated from the fermentation broth of Streptomyces sp. is a natural bioactive compound which is an inhibitor of bacterial cell wall synthesis.
Storage	-20°C	CAS	3819-76-9
Link

[Date : August 09 2026 00:07]

O-Carbamyl-D-serine <Inhibitor of bacterial cell wall synthesis>

DatasheetThis may not be the latest data sheet.

Product Code: 20324
Supplier: IMC
Size: 10mg
Price: $500

Description	M.W.: 148.118 Purity : >98% (qNMR) Molecular Formula : C4H8N2O4 Solubility : Soluble in H2O, O-Carbamyl-D-serine which was isolated from the fermentation broth of Streptomyces sp. is a natural bioactive compound which is an inhibitor of bacterial cell wall synthesis.
Storage	-20°C	CAS	3819-76-9
Link

Contact

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