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HOME> Products> Natural and Chemical compound> Enzyme inhibitor> Benarthin

Bioactive compound exhibiting pyroglutamyl peptidase (PG-peptidase) inhibition Benarthin

Date：July 22 2026Web Page No：718217

Benarthin is a bioactive natural compound harboring the catechol group, was isolated from the fermentation broth of Streptomyces xanthophaerus. This compound inhibited pyroglutamyl peptidase (PG-peptidase) competitively (K_i:1.2 x 10^-6 M).¹⁾ In addition, structural relationship studies of synthesizesd benarthin analogs indicated that the catechol group of benarthin was essential moiety for the inhibition of pyroglutamyl peptidase.^2,3)
Moreover, tribenarthin was reported as a related compound harboring a trimer structure composed of benarthin originated structure, and was described as a siderophore-like compound harboring a catechol-peptide structure.⁴⁾

* This product is for research use only.
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Chemical Structure of Benarthin (#20323)

Specifications
Examples of physiological activities and effects
Reference
Product information

Specifications

CAS#	143651-45-0
Molecular Formula	C₁₇H₂₅N₅O₇
Molecular Weight	411.415
Source	Streptomyces sp.
Purity	>95% (HPLC)
Long Term Storage	at -20˚C
Solubility	Soluble in MeOH, DMSO, H₂O

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Examples of physiological activities and effects

Benarthin inhibited pyroglutamyl peptidase (PG-peptidase) competitively (K_i:1.2 x 10^-6 M).¹⁾

* Biological activity of the product was not verified. The values shown above were cited from the references.

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Reference

Aoyagi, T., et al., J. Antibiot., 45(7), 1079-1083(1992). [PMID:1355471]
Hatsu, M., et al., J. Antibiot., 45(7), 1084-1087(1992). [PMID:1355472]
Hatsu, M., et al., J. Antibiot., 45(7), 1088-1095(1992). [PMID:1355473]
Matsuo, Y., et al., J. Nat. Prod., 74(11), 2371-2376(2011). [PMID:22014204]

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Product information

[Date : July 28 2026 00:08]

Detail Product Name Product Code Supplier Size Price

Benarthin <pyroglutamyl peptidase inhibitor>
DatasheetThis may not be the latest data sheet. 20323 IMCInstitute of Microbial Chemistry 2 mg $500

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Description	M.W.: 411.415 Purity : >95% (HPLC) Molecular Formula : C17H25N5O7 Solubility : Soluble in H2O, MeOH, DMSO, Benarthin is a natural bioactive compound which is an inhibitor of pyroglutamyl peptidase, and it was isolated from the fermentation broth of Streptomyces xanthophaerus. In addition, structural relationship studies of synthesizesd benarthin analogs indicated that the catechol group of benarthin was essential moiety for the inhibition of pyroglutamyl peptidase.
Storage	-20°C	CAS	143651-45-0
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[Date : July 28 2026 00:08]

Benarthin <pyroglutamyl peptidase inhibitor>

DatasheetThis may not be the latest data sheet.

Product Code: 20323
Supplier: IMC
Size: 2mg
Price: $500

Description	M.W.: 411.415 Purity : >95% (HPLC) Molecular Formula : C17H25N5O7 Solubility : Soluble in H2O, MeOH, DMSO, Benarthin is a natural bioactive compound which is an inhibitor of pyroglutamyl peptidase, and it was isolated from the fermentation broth of Streptomyces xanthophaerus. In addition, structural relationship studies of synthesizesd benarthin analogs indicated that the catechol group of benarthin was essential moiety for the inhibition of pyroglutamyl peptidase.
Storage	-20°C	CAS	143651-45-0
Link

Contact

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