Natural bioactive compound harboring anti-tuberculosis activity Pyridomycin
Date：April 07 2026Web Page No：520114
Pyridomycin is a cyclic peptide compound discovered from Streptomyces. Maeda, Umezawa, and their collagues in Institute of Microbial Chemistry reported that the compound exhibited antibacterial activity against Mycobacterium tuberculosis.1~3)
This compound inhibited competitively InhA which is NADH dependent enoyl-ACP reductase in synthetic pathway of mycolic acids as a molecular target of antituberculosis drug, isoniazid, in a different manner from the drug. In addition, this compound also showed the inhibitory activity to a similar level of wild type M. tuberculosis against drug-resistant bacteria harboring a mutation of catalase-peroxidase (KatG) to obtain isoniazid resistance.4,5)
Therefore, the bioactive compound has provided interesting insights into the development of novel anti-tuberculosis drugs.
* This product is for research use only.
* Please do not hesitate to contact Funakoshi if you need a Structure Data Format (SDF) file and/or bulk quantity of the compound.
Structure of Pyridomycin (#10080)
Specification
| CAS# | 18791-21-4 |
|---|---|
| Molecular Formula | C27H32N4O8 |
| Molecular Weight | 540.573 |
| Purity | >90% (HPLC) |
| Solubility | Soluble in MeOH and DMSO. |
Application Note
- Pyridomycin inhibited growth of Mycobacterium tuberculosis (1.6 μg/ml). 1)
- This compound competitively inhibited enoyl-ACP reductase (InhA) in M. tuberculosis (Ki: 6.5 μM).4)
- This compound showed the inhibitory activity to a similar level of wild type M. tuberculosis against drug-resistant bacteria harboring a mutation of catalase-peroxidase (KatG) to obtain isoniazid resistance.4)
- X-ray structure analysis of pyridomycin and InhA complex revealed that pyridomycin forms a unique structure to block both NADH cofactor- and lipid substrate-binding pockets of InhA.5)
*Biological activity of the product was not verified. The values shown above were cited from the references.
Reference
- Maeda, K., et al., J. Antibiotics, 6(3), 140(1953). [PMID:13096450]
- Ogawara, H., et al., Chem. Pharm. Bull., 16(4), 679-687(1968). [PMID:5677624]
- Koyama, G., et al., Tetrahedron Lett., 8(37), 3587-3590(1967). [DOI:10.1016/S0040-4039(01)89801-4]
- Hartkoorn, R. C., et al., EMBO Mol. Med., 4(10), 1032-1042(2012). [PMID:22987724]
- Hartkoorn, R. C., et al., Nat. Chem. Biol., 10(2), 96-98(2014). [PMID:24292073]
Product Information
[Date : April 11 2026 00:08]
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Pyridomycin, Antimycobacterial, Enoyl-ACP Reductase Inhibitor DatasheetThis may not be the latest data sheet. |
10080 | IMCInstitute of Microbial Chemistry | 2 mg | $500 | |||||||||||||||||||||||||||||||
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[Date : April 11 2026 00:08]
Pyridomycin, Antimycobacterial, Enoyl-ACP Reductase Inhibitor
DatasheetThis may not be the latest data sheet.
- Product Code: 10080
- Supplier: IMC
- Size: 2mg
- Price: $500
| Description |
M.W.: 540.573 Purity : >90% (HPLC) Molecular Formula : C27H32N4O8 Solubility : Soluble in MeOH and DMSO Pyridomycin is a cyclic peptide compound harboring antibiotic activity against Mycobacterium tuberculosis. This compound inhibits competitively against NADH dependent enoyl-ACP reductase (InhA) via a different mechanism of isoniazid. |
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| Storage | -20°C | CAS | 18791-21-4 |
| Link |
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