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HOME> Products> Natural and Chemical compound> Enzyme inhibitor> Belactin A [CAS: 175448-24-5]

Specific inhibitor of serine carboxypeptidase Y Belactin A [CAS: 175448-24-5]

Date：October 10 2025Web Page No：520101

Belactin A is a natural compound harboring β-lactone ring, which was isolated from culture filtrate of Saccharopolyspora. Comparison to ebelactones A and B, belactin A had specific inhibitory activity toward serine carboxypeptidase Y (CP-Y).^1,2) CP-Y was known as a protease located in vacuoles in yeast.³⁾
Belactin A is a useful research tool for biochemistry, cell biology, and pharmacy relevant to serine carboxylase.²⁾
* This product is for research use only.

Structure of Belactin A (#17736)

Specification
Application Note
Reference
Product Information

Specification

CAS#	175448-24-5
Molecular Formula	C₁₇H₂₁ClN₂O₄
Molecular Weight	352.815
Purity	>98% (HPLC)
Solubility	Soluble in DMSO and MeOH

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Application Note

Belactin A did not exhibit antibacterial activities at 100 μg/ml.¹⁾
As intraperitoneal administration of belactin A to mice (100 mg/kg) did not exhibit acute toxicity, toxicity of it was considered to low.¹⁾
Belactin A had a high inhibitory activity toward CP-Y within various peptidases. In contrast, this compound exhibited weak inhibitory activities to dipeptidyl aminopeptidase 1 and prolyl endopeptidase, it did not have an inhibitory activity toward other peptidases.¹⁾
Although ebelacton A which is a β-lactone-containing compound as same as belactin A inhibited esterases and lipases, belactin A showed specific inhibitory activity to CP-Y.²⁾

Enzyme Family	Enzyme Name	IC₅₀ (μg/ml)
Serine carboxypeptidase	CP-Y	0.18
Metallocarboxypeptidase	CP-A	>100
	CP-B	>100
	CP-N	>100
Aminopeptidase	AP-M	>100
Aminopeptidase	Leu-AP	>100
Dipeptidylaminopeptidase	DPP-1	100
	DPP-2	>100
	DPP-4	>100
Serine endopeptidase	Chymotrypsin	>100
	Thrombin	>100
	Prolyl endopeptidase	100
Esterase		>100
Lipase		>100

* Biological activity of the product was not verified. The values shown above were cited from the references.

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Reference

Murakami S., et al., J. Enzyme Inhibition, 9 (4), 263~275 (1995). [PMID:8598536]
Murakami S., et al., J. Enzyme Inhibition, 9 (4), 277~284 (1995). [PMID:8598537]
Breddam, K., Carlsberg Res. Commun., 51 (2), 83~128 (1986).

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Product Information

[Date : October 22 2025 00:07]

Detail Product Name Product Code Supplier Size Price

Belactin A <Serine Carboxypeptidase Inhibitor>
DatasheetThis may not be the latest data sheet. 17736 IMCInstitute of Microbial Chemistry 1 mg $500

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Description	M.W.: 352.815 Purity : >98% (HPLC) Molecular Formula : C17H21ClN2O4 Solubility : Soluble in MeOH, and DMSO Belactin A is a natural compound harboring β-lactone ring and was reported that it has a specific inhibitory activity toward serine carboxypeptidase Y (CP-Y). CP-Y was known as a protease located in vacuoles in yeast.
Storage	-20°C	CAS	175448-24-5
Link

[Date : October 22 2025 00:07]

Belactin A <Serine Carboxypeptidase Inhibitor>

DatasheetThis may not be the latest data sheet.

Product Code: 17736
Supplier: IMC
Size: 1mg
Price: $500

Description	M.W.: 352.815 Purity : >98% (HPLC) Molecular Formula : C17H21ClN2O4 Solubility : Soluble in MeOH, and DMSO Belactin A is a natural compound harboring β-lactone ring and was reported that it has a specific inhibitory activity toward serine carboxypeptidase Y (CP-Y). CP-Y was known as a protease located in vacuoles in yeast.
Storage	-20°C	CAS	175448-24-5
Link

Contact

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