Keyword	：

Keyword	：
Supplier	：Select	Product code	：
Product type	：	Discontinued product	：

Keyword	：
Supplier	：Select	Product code	：
Discontinued product	：

AntigenHelp	：	Cross reactivityHelp	：	Host animalHelp	：
ConjugationHelp	：	ApplicationHelp	：	PurificationHelp	：
AbsorptionHelp	：	IsotypeHelp	：	CloneHelp	：

Product type	：	Match condition	：	Discontinued product	：

Supplier	：Select	Product code	：
Supplier	：Select	Product code	：
Supplier	：Select	Product code	：
Supplier	：Select	Product code	：
Supplier	：Select	Product code	：
Supplier	：Select	Product code	：
Supplier	：Select	Product code	：
Supplier	：Select	Product code	：
Supplier	：Select	Product code	：
Supplier	：Select	Product code	：

CAS No	：

Supplier	：Select	Discontinued product	：

WEB page No search	：

HOME> Products> Natural and Chemical compound> Other natural compound> Clazamycin A (Hydrochloride) [CAS: 71743-75-4]

Bioactive compound harboring antibacterial, and antitumor activities Clazamycin A (Hydrochloride) [CAS: 71743-75-4]

Date：July 16 2025Web Page No：520095

Clazamycin A which has basic structure of pyrrolizidine was isolated from culture filtrates of Streptomyces. It was reported that this compound had a weak antibacterial activity and extended survival duration of mice inoculated leukemia L-1210 cells by administration of it everyday for 10 days.¹⁾ In addition, this compound inhibited DNA synthesis, membrane transport of some specific amino acids, and other nutrients in Escherichia coli.²⁾
* This product is for research use only.

Structure of Clazamycin A (hydrochloride) (#16715)

Specification
Application Note
Equilibration between clazaymcin A and B
Reference
Product Information

Specification

CAS#	71743-75-4
Molecular Formula	C₇H₉CIN₂O･HCl (mono HCl salt)
Molecular Weight	209.07
Purity	>95% (HPLC)
Solubility	Soluble in DMSO and H₂O Silghtly soluble in MeOH

Go back to index

Application Note

Intravenously administration of clazamycin A (12.5~100ug) extended 30% of survival duration of mice which were inoculated leukemia L-1210 cells.¹⁾
Clazamycin A inhibited the membrane transport of N-acetylglucosamine and leucine.²⁾
Clazamycin A inhibited DNA synthesis at the polymerization step in E. coli.²⁾

Go back to index

Equilibration between clazaymcin A and B

Clazamycin A can be changed to its isomer clazamycin B in aqueous solution in a pH dependent manner and form the equilibrium mixture of them.^{1, 3)}
Although this product contains less than 5% of clazamycin B, it is possible to prevent decomposition and isomerization to clazamycin B at pH 3 or lower.
In order to avoid the decomposition and isomerization, it is recommended to resolve into the acidic solution, and store at 4 degree or lower. They should be used within a couple of days.

Go back to index

Reference

Horiuchi, Y., et al., J. Antibiotics, 32 (7), 762~764 (1979). [PMID:541271]
Hori, M., et al., J. Antibiotics, 37 (3), 260~266 (1984). [PMID:6373701]
Buechter, D.D. and Thurston, D.E., J. Nat. Prod., 50 (3), 360~367 (1987). [PMID:3668555]

Go back to index

Product Information

[Date : July 19 2025 00:08]

Detail Product Name Product Code Supplier Size Price

Clazamycin A(hydrochloride), Antibacterial, Antitumor
DatasheetThis may not be the latest data sheet. 16715 IMCInstitute of Microbial Chemistry 1 mg $500

Contact

Description	M.W.: 209.070 Purity : >95% (HPLC) Molecular Formula : C7H9ClN2O･HCl Solubility : Soluble in H2O, and DMSO, slightly soluble in MeOH Clazamycin A is a bioactive compound harboring an antibacterial activity. In addition, it extended lifespan in mice which were inoculated leukemia cells and inhibited DNA synthesis in E. coli.
Storage	-20°C	CAS	71743-75-4
Link

[Date : July 19 2025 00:08]

Clazamycin A(hydrochloride), Antibacterial, Antitumor

DatasheetThis may not be the latest data sheet.

Product Code: 16715
Supplier: IMC
Size: 1mg
Price: $500

Description	M.W.: 209.070 Purity : >95% (HPLC) Molecular Formula : C7H9ClN2O･HCl Solubility : Soluble in H2O, and DMSO, slightly soluble in MeOH Clazamycin A is a bioactive compound harboring an antibacterial activity. In addition, it extended lifespan in mice which were inoculated leukemia cells and inhibited DNA synthesis in E. coli.
Storage	-20°C	CAS	71743-75-4
Link

Contact

Go back to index

CONTACT

export@funakoshi.co.jp

※Prices on our website are for your reference only. Please inquire your distributor for your prices.
※Please note that Product Information or Price may change without notice.