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This kit can measure lithium in serum samples. Lithium Assay kit LS | 10 mins | Easy Assay in microplate reader

Date：November 22 2016Web Page No：46145

Metallogenics Co.,Ltd.

Lithium Assay kit LS
Download here.

A simple and sensitive test kit for lithium (lithium carbonate) in serum samples. It has been suggested that lithium may affect mental function.

Significance of Lithium Determination

Lithium (Li) is associated with the release and suppression of serotonin, dopamine, and adrenaline in neurons, and is known to increase white blood cells, decrease blood pressure, and affect reproduction.
In the field of pharmacotherapy, lithium carbonate is frequently used as a lithium donor as a first-line or second-line drug in the treatment of bipolar disorder. However, excessive doses of lithium have been associated with kidney damage and other serious side effects, and medication management is important.
Recently, the effects of lithium on diseases related to oxidative stress in addition to mood stabilization have been reported one after another, and research on the effects of lithium on other diseases is being reconsidered.


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Assay Principle

It observes the color development of the visible part due to chelate complex formation of polyhalogen-substituted porphyrins and lithium ions, and determines the lithium concentration. It is the world's first stable liquid color development kit for microplate readers. (Patent number: JP 5100903)

Assay Principle for Lithium Assay kit LS

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Features

  • Polyfluoroporphyrin reacts with lithium (Li+) in serum and develops a vivid color. In addition, even after 30 minutes of color development, the absorbance of both high and low concentration lithium samples remains constant, resulting in excellent stability.
  • Measurable with conventional microplate readers, as 96 well plate reader.
  • Each component can be stored stably for one month after opening.
  • Multi-point calibration is not required, because calibration is performed with two points, the standard and the blank sample included in the kit.
  • Sample type: serum, plasma (＊Do not use heparin lithium blood collection tubes.)
  • Assay range: 0.03-3.0 mM
  • Assay time: 10 minutes

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Example of Use

Lithium Assay kit LS : Lithium Assay Kit by microplate reader
Correlation data between this kit and Atomic Absorption Spectrometry method

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Citations

Click here
No. Literature information Remarks URL
1 Dietary zinc deficiency induces oxidative stress and promotes tumor necrosis factor-α- and interleukin-1β-induced RANKL expression in rat bone　Journal of Clinical Biochemistry and Nutrition, 6.Feb.2016. p1-8

 PubMed
2 Conformational Disorder of the Most Immature Cu,Zn-Superoxide Dismutase Leading to Amyotrophic Lateral Sclerosis　J. Biol. Chem., pii: jbc.M115.683763.

 PubMed
3 Zinc Deficiency Increases Serum Concentrations of Parathyroid Hormone through a Decrease in Serum Calcium and Induces Bone Fragility in Rats Journal of Nutritional Science and Vitaminology; Vol. 61 (2015) No. 5 p. 382-390.

 PubMed
4 Dietary zinc supplementation increased TNFα and IL1β-induced RANKL expression, resulting in a decrease in bone mineral density in rats Journal of Clinical Biochemistry and Nutrition; 27.Nov.2015. p. 1-18

 PubMed
5 Calcium ions rescue human lung epithelial cells from the toxicity of zinc oxide nanoparticles　The Journal of Toxicological Sciences;Vol. 40 (2015) No. 5 October p. 625-635

 PubMed
6 Distribution and toxicity evaluation of ZnO dispersion nanoparticles in single intravenously exposed mice　The Journal of Medical Investigation;Vol. 62 (2015) No. 1.2 p. 45-50

 PubMed
7 Analysis of the binding of bovine and human fibrinogen to ferritin: evidence that fibrinogen is a common ferritin-binding protein in mammals　Biometals;August 2015, Volume 28, Issue 4, pp 679-685

 PubMed
8 Protective activity of carnosine and anserine against zinc-induced neurotoxicity: a possible treatment for vascular dementia 　Metallomics; 2015,7, 1233-1239

 PubMed
9 Simple differentiation of sake (Japanese alcoholic beverage) based on trace inorganic components using colorimetric methods 　Journal of Bioscience and Bioengineering; 13 June 2015

 PubMed
10 Sexual development of Schizosaccharomyces pombe is induced by zinc or iron limitation through Ecl1 family genes. Molecular Genetics and Genomics, February 2015, Volume 290, Issue 1, pp 173-185

 PubMed
11 Synthesis of amino-functionalized mesoporous silica sheets and their application for metal ion capture. 　Journal of Asian Ceramic Societies ; November 15, 2014

 PubMed
12 Study on the blood compatibility and biodegradation properties of magnesium alloys. 　Mater Sci Eng C ; November 12, 2014

 PubMed
13 A Primary Role for Disulfide Formation in the Productive Folding of Prokaryotic Cu,Zn-superoxide dismutase. 　J Biol Chem ; June 10, 2014

 PubMed
14 Improvement of depression-like behavior and memory impairment with the ethanol extract of Pleurotus eryngii in ovariectomized rats 　Biol Pharm Bull ; December 1, 2013

 PubMed
15 SOD1 as a molecular switch for initiating the homeostatic ER stress response under zinc deficiency.　Mol Cell ; October 10, 2013
Homma K et al
2013/01/01
 PubMed
16 TEMPO-oxidized cellulose hydrogel as a high-capacity and reusable heavy metal ion adsorbent 　J Hazard Mater ; September 15, 2013

 PubMed
17 The Therapeutic Effect on Bone Mineral Formation from Biomimetic Zinc Containing Tricalcium Phosphate (ZnTCP) in Zinc-Deficient Osteoporotic Mice 　PLoS ONE ; August 13, 2013

 PubMed
18 Synergic Toxicity of Solid Particles and Released Zinc from Zinc Oxide Nanoparticles to Human Lung Epithelial Cells 　Nano Biomedicine ; 2012

 PubMed
19 Potential involvement of glycogen synthase kinase (GSK)-3β in a rat model of multiple sclerosis: evidenced by lithium treatment. Anat Cell Biol 2017 Mar;50(1):48-59
Ahn M et al
2017/01/01
 PubMed
  • No.: 1
  • Literature information:
    Dietary zinc deficiency induces oxidative stress and promotes tumor necrosis factor-α- and interleukin-1β-induced RANKL expression in rat bone　Journal of Clinical Biochemistry and Nutrition, 6.Feb.2016. p1-8

  • Remarks:
  • URL:
    PubMed
  • No.: 2
  • Literature information:
    Conformational Disorder of the Most Immature Cu,Zn-Superoxide Dismutase Leading to Amyotrophic Lateral Sclerosis　J. Biol. Chem., pii: jbc.M115.683763.

  • Remarks:
  • URL:
    PubMed
  • No.: 3
  • Literature information:
    Zinc Deficiency Increases Serum Concentrations of Parathyroid Hormone through a Decrease in Serum Calcium and Induces Bone Fragility in Rats Journal of Nutritional Science and Vitaminology; Vol. 61 (2015) No. 5 p. 382-390.

  • Remarks:
  • URL:
    PubMed
  • No.: 4
  • Literature information:
    Dietary zinc supplementation increased TNF留 and IL1硫-induced RANKL expression, resulting in a decrease in bone mineral density in rats Journal of Clinical Biochemistry and Nutrition; 27.Nov.2015. p. 1-18

  • Remarks:
  • URL:
    PubMed
  • No.: 5
  • Literature information:
    Calcium ions rescue human lung epithelial cells from the toxicity of zinc oxide nanoparticles　The Journal of Toxicological Sciences;Vol. 40 (2015) No. 5 October p. 625-635

  • Remarks:
  • URL:
    PubMed
  • No.: 6
  • Literature information:
    Distribution and toxicity evaluation of ZnO dispersion nanoparticles in single intravenously exposed mice　The Journal of Medical Investigation;Vol. 62 (2015) No. 1.2 p. 45-50

  • Remarks:
  • URL:
    PubMed
  • No.: 7
  • Literature information:
    Analysis of the binding of bovine and human fibrinogen to ferritin: evidence that fibrinogen is a common ferritin-binding protein in mammals　Biometals;August 2015, Volume 28, Issue 4, pp 679-685

  • Remarks:
  • URL:
    PubMed
  • No.: 8
  • Literature information:
    Protective activity of carnosine and anserine against zinc-induced neurotoxicity: a possible treatment for vascular dementia 　Metallomics; 2015,7, 1233-1239

  • Remarks:
  • URL:
    PubMed
  • No.: 9
  • Literature information:
    Simple differentiation of sake (Japanese alcoholic beverage) based on trace inorganic components using colorimetric methods 　Journal of Bioscience and Bioengineering; 13 June 2015

  • Remarks:
  • URL:
    PubMed
  • No.: 10
  • Literature information:
    Sexual development of Schizosaccharomyces pombe is induced by zinc or iron limitation through Ecl1 family genes. Molecular Genetics and Genomics, February 2015, Volume 290, Issue 1, pp 173-185

  • Remarks:
  • URL:
    PubMed
  • No.: 11
  • Literature information:
    Synthesis of amino-functionalized mesoporous silica sheets and their application for metal ion capture. 　Journal of Asian Ceramic Societies ; November 15, 2014

  • Remarks:
  • URL:
    PubMed
  • No.: 12
  • Literature information:
    Study on the blood compatibility and biodegradation properties of magnesium alloys. 　Mater Sci Eng C ; November 12, 2014

  • Remarks:
  • URL:
    PubMed
  • No.: 13
  • Literature information:
    A Primary Role for Disulfide Formation in the Productive Folding of Prokaryotic Cu,Zn-superoxide dismutase. 　J Biol Chem ; June 10, 2014

  • Remarks:
  • URL:
    PubMed
  • No.: 14
  • Literature information:
    Improvement of depression-like behavior and memory impairment with the ethanol extract of Pleurotus eryngii in ovariectomized rats 　Biol Pharm Bull ; December 1, 2013

  • Remarks:
  • URL:
    PubMed
  • No.: 15
  • Literature information:
    SOD1 as a molecular switch for initiating the homeostatic ER stress response under zinc deficiency.　Mol Cell ; October 10, 2013
    Homma K et al
    2013/01/01
  • Remarks:
  • URL:
    PubMed
  • No.: 16
  • Literature information:
    TEMPO-oxidized cellulose hydrogel as a high-capacity and reusable heavy metal ion adsorbent 　J Hazard Mater ; September 15, 2013

  • Remarks:
  • URL:
    PubMed
  • No.: 17
  • Literature information:
    The Therapeutic Effect on Bone Mineral Formation from Biomimetic Zinc Containing Tricalcium Phosphate (ZnTCP) in Zinc-Deficient Osteoporotic Mice 　PLoS ONE ; August 13, 2013

  • Remarks:
  • URL:
    PubMed
  • No.: 18
  • Literature information:
    Synergic Toxicity of Solid Particles and Released Zinc from Zinc Oxide Nanoparticles to Human Lung Epithelial Cells 　Nano Biomedicine ; 2012

  • Remarks:
  • URL:
    PubMed
  • No.: 19
  • Literature information:
    Potential involvement of glycogen synthase kinase (GSK)-3β in a rat model of multiple sclerosis: evidenced by lithium treatment. Anat Cell Biol 2017 Mar;50(1):48-59
    Ahn M et al
    2017/01/01
  • Remarks:
  • URL:
    PubMed

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Product Information

[Date : June 28 2025 00:08]

Detail Product Name Product Code Supplier Size Price
Lithium Assay kit LS <Polyfluoroporphyrin, 100tests>
DatasheetThis may not be the latest data sheet. 		LI01ME AKJMetallogenics Co.,Ltd. 1 kit $529

Description A kit for measuring lithium in biological samples. Assay range: 0.03-3 mM, Number of assays: 100 tests, Detection method: colorimetric, Samples: serum, plasma
Storage 4°C CAS
Link

[Date : June 28 2025 00:08]

Lithium Assay kit LS <Polyfluoroporphyrin, 100tests>

DatasheetThis may not be the latest data sheet.


  • Product Code: LI01ME
  • Supplier: AKJ
  • Size: 1kit
  • Price: $529

Description A kit for measuring lithium in biological samples. Assay range: 0.03-3 mM, Number of assays: 100 tests, Detection method: colorimetric, Samples: serum, plasma
Storage 4°C CAS
Link

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