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Natural Killer T (NKT) cells activator α-GalCer (KRN7000) and 7DW8-5

Date：September 04 2014Web Page No：46127

Funakoshi Co.,Ltd.

α-Galactosylceramide (α-Gal-Cer; KRN7000) is a glycosphingolipid orignally isolated of Agelas mauritianus, the marine sponge in Okinawa. It has attracted attention for its antitumor activity.
7DW8-5, derivative of α-Gal-Cer, shows 100-fold stronger adjuvant effect against natural killer T(NKT) cells than α-Gal-Cer.

Appication

  • Immunostimulant
  • Potent stimulator of human and mouse natural killer T (NKT) cells
  • Potent antitumor compound

    • application KRN7000
    application 7DW8-5

    α-Galactosylceramide has wide research and human therapeutic applications. Please learn and find more information at Alpha-GalCer.net.

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α-Galactosylceramide

  • Specific ligand for human and mouse NKT cells
  • Exhibits various immunological effects through NKT cell functions including potent antitumor effect
  • Activates CD1d mediated invariant NKT cells (iNKT cells)
  • Both Th1 and Th2 cytokine are released after activation by KRN7000.

※ Alpha-Gal-Cer (KRN7000) is licensed by Kyowa Hakko Kirin Company. This product is for research use only, not for use in human, therapeutic or diagnostic applications.

Specification

  • Chemical Name : (2S, 3S, 4R)-1-O-(alpha-D-galactosyl)-N-hexacosanoyl-2-amino-1, 3, 4-octadecanetriol
  • Molecular Formula : C50H99NO9
  • CAS No.：158021-47-7
  • M.W. : 858.34
  • Soluble in DMSO

    • α-Galactosylceramide

References

  1. Tashiro T., et al., Int. Immunol., 22 (4), 319～328 (2010).
  2. Emoto M., et al., Infection and Immunity, 78 (6), 2667～2676 (2010).
  3. Sasakawa A., et al., J. Hepatol., 50 (6), 1155～1162 (2009).
  4. Kamijuku H., et al., Mucosal Immunol., 3, 208～218 (2008).
  5. Ishii Y., et al., Front. Biosci., 13, 6214～6228 (2008).
  6. Shimizu K., et al., J. Exp. Med., 204, 2641～2653 (2007).
  7. Kronenberg M., Annu. Rev. Immunol., 23, 877～900 (2005).

[Date : February 15 2024 12:37]

Detail Product Name Product Code Supplier Size Price
alpha-Galactosylceramide <α-GalCer>, <KRN7000>
DatasheetThis may not be the latest data sheet. 		KRN7000 KRNFunakoshi Co.,Ltd. 1 mg $180

Description KRN7000, a glycolipid derived from the marine sponge has a novel α-galactosylceramide (α-GalCer) structure and exhibits potent anti-tumor activity by stimulating a strong immune response. Detailed informations on "Alpha-GalCer.net": http://www.alpha-galcer.net/index.html
Storage -20°C CAS
Link

Natural compound Product List

[Date : February 15 2024 12:37]

alpha-Galactosylceramide <α-GalCer>, <KRN7000>

DatasheetThis may not be the latest data sheet.


  • Product Code: KRN7000
  • Supplier: KRN
  • Size: 1mg
  • Price: $180

Description KRN7000, a glycolipid derived from the marine sponge has a novel α-galactosylceramide (α-GalCer) structure and exhibits potent anti-tumor activity by stimulating a strong immune response. Detailed informations on "Alpha-GalCer.net": http://www.alpha-galcer.net/index.html
Storage -20°C CAS
Link

Natural compound Product List



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7DW8-5

7DW8-5 is on indefinite backorder.

  • Glycolipid derivative of Alpha-GalCer
  • Shows higher affinity with the V14TCR on NKT cells than Alpha-GalCer
  • Can be used as a potential immunotherapeutic reagent against cancer, infectious disease and autoimmune disease models
  • Has ~100 times stronger adjuvant effect than KRN7000

※ 7DW8-5 is licensed by The Rockefeller University. This product is for research use only, not for use in human, therapeutic or diagnostic applications.

Specification

  • Chemical Name : (2S, 3S, 4R)-1-O-(alpha-D-galactopyranosyl)-N-(11-(4-fluorophenyl)undecanoyl) -2-amino-1, 3, 4-octadecanetriol)
  • Molecular Formula : C41H72FNO9
  • CAS No.：1056025-00-3
  • M. W. : 742.00
  • Purity : 98% by HPLC
  • Soluble in DMSO

    • Natural Killer T (NKT) cells activator : 7DW8-5

References

  1. Li X., et al., Proc. Natl. Acad. Sci. USA, 107, 13010～13015 (2010).
  2. Padte N.N., et al., Clin. Immunol., 140, 142～151 (2011).

[Date : February 15 2024 12:37]

Detail Product Name Product Code Supplier Size Price

[Date : February 15 2024 12:37]

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