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HOME> Products> Antibody> Payload Antibodies

Next-Gen Antibodies: Transforming ADC Research Payload Antibodies

Date：May 12 2026Web Page No：160784

These antibodies specifically recognize the drug payload of an Antibody-Drug Conjugate (ADC), enabling detection and quantification via ELISA and immunohistochemistry (IHC) — methods that previously required expensive equipment like HPLC-MS/MS. They are widely applicable, ranging from early-stage development screening to preclinical pharmacokinetics (PK) analysis and tissue distribution studies.

＊The products are for research use only. Not for therapeutic or diagnostic use.

What is ADC Payloads
Lineup
Example of Use
Product Information

What is ADC Payloads

DM1

A cytotoxic payload utilized in antibody-drug conjugates (ADCs) that acts by inhibiting microtubule polymerization. A prominent example is trastuzumab emtansine (T-DM1, trade name: Kadcyla). T-DM1 is composed of the anti-HER2 antibody trastuzumab, a linker, and DM1, specifically targeting HER2-positive breast cancer.

MMAE

A representative cytotoxic payload utilized in ADCs that induces mitotic arrest and cancer cell apoptosis by inhibiting microtubule formation. Additionally, the liberated MMAE can exert a bystander killing effect on adjacent cell populations.

DXd/Exatecan

A cytotoxic payload utilized in ADCs, functioning as an exatecan-derived topoisomerase I inhibitor. It mediates intracellular cytotoxicity and demonstrates a bystander effect by diffusing into and eliminating surrounding cells.

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Lineup

Name	Host Species (Clonality)	Clone	Code
DM1 antibody	Mouse (Monoclonal)	AB12204	PP-AB12204-0R
DXd/Exatecan antibody, HRP labeled	Human (Monoclonal)	AB12703	PP-AB12703-0R
MMAE antibody	Mouse (Monoclonal)	AB12401	PP-AB12401-0R

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Example of Use

DM1 antibody (PP-AB12204-0R)

DM1 antibody (PP-AB12204) IF image — **Immunocytochemistry**

Sample: SK-BR-3 cells (wild type(WT) / SLC46A3^* knockout(KO) )
＊ SLC46A3: lysosomal membrane protein
Treatment: DM1-conjugated antibody (2 μg/mL) for 15 min, washed, and incubated overnight.
Fixation: 4% PFA
Staining: Primary Ab: DM1 antibody (PP-AB12204-0R, 5 μg/mL)
Secondary Ab: Mouse IgG-Alexa Fluor 488 (Green)
Counterstain: Hoechst 33342 (Blue)

※ Courtesy of Prof. Katsuhisa Inoue of Tokyo University of Pharmacy and Life Sciences

DM1 antibody ELISA — **Comparison of DM1-conjugated antibody(DM1-Ab) and non-conjugated antibody(Naked Ab)**

Anti-DM1 antibody (PP-AB12204-0R) was immobilized at 2.5 μg/mL. Serial dilutions of DM1-Ab or Naked Ab, diluted in 50% mouse plasma, were added. This was followed by the addition of HRP-labeled anti-human IgG antibody, and detection was performed using an HRP-based immunoassay.

Limit of Detection: 0.14 ng/mL
Range of Quantification: 0.41-11.1 ng/mL

DXd/Exatecan antibody (PP-AB12703-0R）

Comparison of DXd-conjugated antibody and non-conjugated antibody (Naked Ab) — **Comparison of DXd-conjugated antibody(DXd-Ab) and non-conjugated antibody(Naked Ab)**

Recombinant DXd-binding protein was immobilized at 2.5 μg/mL. After blocking, serial dilutions of DXd-Ab or Naked antibody in 50% mouse plasma were added. Subsequently, HRP-labeled anti-DXd/Exatecan antibody (PP-AB12703-0R) was added at a 1:2,500 dilution (final conc.: 0.2 μg/mL), and detection was performed using an HRP-based immunoassay.

Limit of Detection:0.68 ng/mL
Range of Quantification: 2.06-55.6 ng/mL

Plasma pharmacokinetics of DXd-Ab in mice after a single doseA — **Plasma pharmacokinetics of DXd-conjugated antibody(DXd-Ab) after a single dose in mice**

Following a single 3 mg/kg dose in mice, plasma pharmacokinetics of DXd-Ab were measured using a bridging ELISA with recombinant DXd-Ab binding protein and HRP-labeled anti-DXd/Exatecan antibody (Mean ± SD, n=3 per time point). Blood samples were collected at 5 min and 3, 7 and 14 days post-dose. Plasma samples were diluted 1:16,000–1:128,000 for the 5-min time point, and 1:4,000–1:32,000 for the 3–14 day time points with each dilution measured in triplicate. Concentrations within the validated range were back-calculated, and the mean value of eligible dilutions was calculated for each animal.

MMAE antibody (PP-AB12401-0R)

MMAE antibody bridging ELISA — **Bridging ELISA using MMAE antibody**

We investigated the effect of the coating concentration of the anti-MMAE antibody. Anti-MMAE antibody (PP-AB12401-0R) was immobilized at 2.5 and 5.0 μg/mL, followed by the addition of a serial dilution of MMAE-conjugated antibodies. Subsequently, HRP-labeled anti-human IgG antibody was added, and detection was performed via HRP-based immunoassay.

Comparison of MMAE-Ab & Naked Ab — **Comparison of MMAE-conjugated antibody(MMAE-Ab) and non-conjugated antibody(Naked Ab)**

Anti-MMAE antibody (PP-AB12401-0R) was immobilized at 2.5 μg/mL. A serial dilution of either MMAE-Ab or Naked Ab, diluted in 50% mouse plasma, was then added. Subsequently, HRP-labeled anti-human IgG antibody was added, and detection was performed via HRP-based immunoassay.

Limit of Detection: 1.37 ng/mL
Range of Quantification: 4.12-111 ng/mL

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Product Information

[Date : June 24 2026 00:09]

Detail Product Name Product Code Supplier Size Price

Anti-DM1 mouse monoclonal antibody (1mg/mL)
DatasheetThis may not be the latest data sheet. PP-AB12204-0R PMXPerseus Proteomics Inc. 100 µl $783

Contact

Description	Clone: AB12204, Formulation: DPBS with 0.1% NaN3 as a preservative, DM1 (Mertansine) is a substance used as a payload in antibody-drug conjugates (ADCs) for cancer treatment. It targets cancer cells and exerts its toxicity within these cells. It binds to antibodies and is transported to cancer cells, enhancing their destruction. DM1's potent toxicity makes it a promising option in cancer therapy.
Storage	-20°C
Antigen Species		Host Species	Mouse	Class	IgG	Label	Unlabeled
Cross Reactivity				Application	ELISA,ICC
Clonality		Format		Purification	Protein A/G Affinity Purified	Absorption
Link	Cancer-Related Antibody

Anti-DXd/Exatecan human monoclonal antibody(AB12703), HRP conjugated (0.5mg/mL)
DatasheetThis may not be the latest data sheet. PP-AB12703-0R PMXPerseus Proteomics Inc. 50 µl $1,305

Contact

Description	Clone: AB12703, Formulation: Storage buffer with 50% glycerol and 0.1% ProClin 950 as a preservative, Deruxtecan (DXd) and Exatecan are potent cytotoxic agents used as payloads in antibody-drug conjugates (ADCs) for targeted cancer therapy. Conjugated to monoclonal antibodies, they enable selective delivery to cancer cells, where they inhibit topoisomerase I, disrupting DNA replication and inducing cell death. The high potency and controlled release of DXd and Exatecan make them effective components in ADC-based cancer treatments.
Storage	-20°C
Antigen Species		Host Species	Human	Class		Label	HRP
Cross Reactivity				Application	ELISA
Clonality		Format		Purification		Absorption
Link

Anti-MMAE, Mouse-Mono(AB12401)
DatasheetThis may not be the latest data sheet. PP-AB12401-0R PMXPerseus Proteomics Inc. 100 µl $870

Contact

Description	Clone: AB12401, Formulation: Physiological saline with 0.1% NaN3 as a preservative, Monomethyl auristatin E (MMAE) is a potent cytotoxic agent used as a payload in antibody-drug conjugates (ADCs) for targeted cancer therapy. It is conjugated to monoclonal antibodies, enabling selective delivery to cancer cells, where it exerts its toxic effects to induce cell death. The high potency of MMAE makes it an effective component in ADCbased cancer treatment.
Storage	-20°C
Antigen Species		Host Species	Mouse	Class	IgG	Label	Unlabeled
Cross Reactivity				Application	ELISA
Clonality		Format		Purification	Protein A/G Affinity Purified	Absorption
Link	Cancer-Related Antibody

[Date : June 24 2026 00:09]

Anti-DM1 mouse monoclonal antibody (1mg/mL)

DatasheetThis may not be the latest data sheet.

Product Code: PP-AB12204-0R
Supplier: PMX
Size: 100µl
Price: $783

Description	Clone: AB12204, Formulation: DPBS with 0.1% NaN3 as a preservative, DM1 (Mertansine) is a substance used as a payload in antibody-drug conjugates (ADCs) for cancer treatment. It targets cancer cells and exerts its toxicity within these cells. It binds to antibodies and is transported to cancer cells, enhancing their destruction. DM1's potent toxicity makes it a promising option in cancer therapy.
Storage	-20°C
Antigen Species		Host Species	Mouse
Class	IgG	Label	Unlabeled
Cross Reactivity		Application	ELISA,ICC
Clonality		Format
Purification	Protein A/G Affinity Purified	Absorption
Link	Cancer-Related Antibody

Contact

Anti-DXd/Exatecan human monoclonal antibody(AB12703), HRP conjugated (0.5mg/mL)

DatasheetThis may not be the latest data sheet.

Product Code: PP-AB12703-0R
Supplier: PMX
Size: 50µl
Price: $1,305

Description	Clone: AB12703, Formulation: Storage buffer with 50% glycerol and 0.1% ProClin 950 as a preservative, Deruxtecan (DXd) and Exatecan are potent cytotoxic agents used as payloads in antibody-drug conjugates (ADCs) for targeted cancer therapy. Conjugated to monoclonal antibodies, they enable selective delivery to cancer cells, where they inhibit topoisomerase I, disrupting DNA replication and inducing cell death. The high potency and controlled release of DXd and Exatecan make them effective components in ADC-based cancer treatments.
Storage	-20°C
Antigen Species		Host Species	Human
Class		Label	HRP
Cross Reactivity		Application	ELISA
Clonality		Format
Purification		Absorption
Link

Contact

Anti-MMAE, Mouse-Mono(AB12401)

DatasheetThis may not be the latest data sheet.

Product Code: PP-AB12401-0R
Supplier: PMX
Size: 100µl
Price: $870

Description	Clone: AB12401, Formulation: Physiological saline with 0.1% NaN3 as a preservative, Monomethyl auristatin E (MMAE) is a potent cytotoxic agent used as a payload in antibody-drug conjugates (ADCs) for targeted cancer therapy. It is conjugated to monoclonal antibodies, enabling selective delivery to cancer cells, where it exerts its toxic effects to induce cell death. The high potency of MMAE makes it an effective component in ADCbased cancer treatment.
Storage	-20°C
Antigen Species		Host Species	Mouse
Class	IgG	Label	Unlabeled
Cross Reactivity		Application	ELISA
Clonality		Format
Purification	Protein A/G Affinity Purified	Absorption
Link	Cancer-Related Antibody

Contact

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