Anti-AGEs Monoclonal Antibody (Clone 6D12)
Date：April 10 2015Web Page No：160718
This antibody specifically recognizes Advanced Glycation End Products (AGEs). AGEs play a critical role in the development and progression of diabetic vascular complications, such as diabetic retinopathy and nephropathy. They are highly regarded as essential targets in biomedical research focusing on aging-related chronic illnesses and diabetes-associated diseases.
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Product Information
[Date : August 12 2026 00:07]
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Anti-AGEs, Mouse-Mono (6D12) DatasheetThis may not be the latest data sheet. |
KH001 | MCP | 10 µg | $746 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
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[Date : August 12 2026 00:07]
Anti-AGEs, Mouse-Mono (6D12)
DatasheetThis may not be the latest data sheet.
- Product Code: KH001
- Supplier: MCP
- Size: 10µg
- Price: $746
| Description |
Reaction of protein amino groups with glucose leads, through the early products such as a Schiff base and Amadori rearrangement products, to the formation of advanced glycation end products (AGEs). Recent immunological studies using anti-AGEs antibody (6D12) demonstrated the presence of AGEs-modified proteins in several human tissues: (ⅰ) human lens (nondiabetic and noncataractous), (ⅱ) renal proximal tubules in patients with diabetic nephropathy and chronic renal failure, (ⅲ) diabetic retina, (ⅳ) peripheral nerves of diabetic neuropathy, (ⅴ) atherosclerotic lesions of arterial walls, (ⅵ)β2-microglobulin forming amyloid fibrils in patients with hemodialysis-related amyloidosis, (ⅶ) senile plaques of patients with Alzheimer’s disease, (ⅷ) the peritoneum of CAPD patients, (ⅸ) skin elastin in actinic elastosis, and (ⅹ) ceriod/lipofuscin deposits. These results suggest a potential role of AGEs-modification in normal aging as well as age-enhanced disease processes. This antibody named as 6D12 has been used to demonstrate AGEs-modified proteins in these human tissues, indicating potential usefulness of this antibody for histochemical identification and biochemical quantification of AGEs-modified proteins. |
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| Storage | -20°C | ||
| Antigen Species | Host Species | Mouse | |
| Class | IgG | Label | |
| Cross Reactivity | Human | Application | ELISA,IHC,Western Blot |
| Clonality | Format | ||
| Purification | Affinity Purified | Absorption | |
| Link |
Antibody Product List (AGEs - Ion Channel) |
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Related Product
[Date : August 12 2026 00:07]
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Advanced Glycation End-Product-BSA <AGE-BSA> DatasheetThis may not be the latest data sheet. |
KH001-A | MCP | 1 mg | $873 | |||||||||||||||||||||||||||||||
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[Date : August 12 2026 00:07]
Advanced Glycation End-Product-BSA <AGE-BSA>
DatasheetThis may not be the latest data sheet.
- Product Code: KH001-A
- Supplier: MCP
- Size: 1mg
- Price: $873
| Description |
The products of the nonenzymatic glycation and oxidation of proteins, lipids and nucleic acids, the advanced glycation end-products (AGEs), accumulate in various pathological conditions, such as diabetes, inflammation, renal failure, and aging. AGEs accumulate at site of microvascular injury in diabetes, including the kidney, the retina, and within the vasculature. The enhanced formation of AGEs also exists in various disease, such as atherosclerosis, Alzheimer’s disease, end-stage renal disease (ESRD), rheumatoid arthritis and liver cirrhosis. AGEs can arise not only from glucose, but also from dicarbonyl compounds, short chain-reducing sugars and other metabolic pathways of glucose. This was prepared from D-glucose and BSA. |
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| Storage | -20°C | CAS | |
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