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Clear stain of tumor part and stromal component in cancer tissues Lumican Polyclonal Antibody

Date：June 07 2017Web Page No：160340

Funakoshi Co.,Ltd.

This is a rabbit polyclonal antibody against human Lumican (LUM, Lumican). It is useful for immunostaining because it can sharply stain tumor parts and stromal components of various tumor tissues.

* This product is commercialized by the research result of Departments of Pathology and Integrative Oncological Pathology, Nippon Medical School.

What is Lumican

Lumican is a glycoprotein, consists of 338 amino acids and is a member of small leucine-rich proteoglycan (SLRP) family. Lumican contains tandem leucine-rich repeat region and its central region plays a role in N-linked glycosylation. It has been reported that overexpression of lumican is related to skin cancer, breast cancer, pancreas cancer, lung cancer, colon cancer, malignant melanoma and bone cancer.


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Example of Use

Human pancreatic cancer (formalin-fixed, paraffin embedded) stained with human lumican antibody

Human pancreatic cancer (formalin-fixed, paraffin embedded) stained image


Lung cancer cells

Lung cancer cells

Lung cancer interstitium

Interstitium of lung cancer

Lumican is observed in cancer cells (left image), and interstitium (right image) in lung squamous cell carcinoma.


Western blot analysis on A549 human lung cancer cell lysate

WB for A549 human lung cancer cell lysate

Western blot analysis on A549 human lung cancer cell lysate using this antibody (#FDV-0001). 37KDa band of lumican core protein and glycosylated forms of lumican are observed.


IHC image of a sample from Bowen's disease patient

IHC of a sample from Bowen's disease patient

Immunostaining data from tissue sample of Bowen's disease patient. Lumican expression is detected in cytoplasm of cancer cells at epidermis.

IHC of hidroacanthoma simplex

IHC of a sample from hidroacanthoma simplex

Immunostaining date of a sample from hidroacanthoma simplex. Lumican expression is observed in the cytoplasm of tumor cells in the epidermis.

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Citation

  1. Yamamoto, T., et al., "Secreted 70kDa lumican stimulates growth and inhibits invasion of human pancreatic cancer", Cancer Lett., 320(1), 31-39 (2012). [PMID：22266188]
  2. Ishiwata, T., et al., "Enhanced expression of lumican inhibited the attachment and growth of human embryonic kidney 293 cells", Exp. Mol. Pathol., 88(3), 363-370 (2010). [PMID：20138170]
  3. Matsuda, Y., et al., "Expression and roles of lumican in lung adenocarcinoma and squamous cell carcinoma", Int. J. Oncol., 33(6), 1177-1185 (2008). [PMID：19020750]
  4. Ishiwata, T., et al., "Role of lumican in cancer cells and adjacent stromal tissues in human pancreatic cancer", Oncol. Rep., 18(3), 537-543 (2007). [PMID：17671699]
  5. Seya, T., et al., "Lumican expression in advanced colorectal cancer with nodal metastasis correlates with poor prognosis", Oncol. Rep., 16(6), 1225-1230 (2006). [PMID：17089042]
  6. Shinji, S., et al., "Different expression levels of lumican in human carcinoid tumor and neuroendocrine cell carcinoma", Int. J. Oncol., 26(4), 873-880 (2005). [PMID：15753980]
  7. Kusafuka, K., et al., "Lumican expression is associated with the formation of mesenchyme-like elements in salivary pleomorphic adenomas" J. Pathol., 203(4), 953-960 (2004). [PMID：15258999]
  8. Ishiwata, T., et al., "Effect of morpholino antisense oligonucleotide against lumican mRNA in human embryonic kidney (HEK) 293 cells", Pathol. Int., 54(2), 77-81 (2004). [PMID：14720136]
  9. Saika, S., et al., "Response of lens epithelial cells to injury: role of lumican in epithelial-mesenchymal transition", Invest. Ophthalmol. Vis. Sci., 44(5), 2094-2102 (2003). [PMID：]
  10. Naito, Z., et al., "Transient and ectopic expression of lumican by acinar cells in L-arginine-induced acute pancreatitis", Exp. Mol. Pathol., 74(1), 33-39 (2003). [PMID：12645630]
  11. Lu, Y. P., et al., "Expression of lumican in human colorectal cancer cells", Pathol. Int., 52(8), 519-526 (2002). [PMID：12366811]
  12. Naito, Z., et al., "Expression and accumulation of lumican protein in uterine cervical cancer cells at the periphery of cancer nests", Int. J. Oncol., 20(5), 943-948 (2002). [PMID：11956587]
  13. Onda, M., et al., "Expression of lumican in thickened intima and smooth muscle cells in human coronary atherosclerosis", Exp. Mol. Pathol., 72(2), 142-149 (2002). [PMID：11890723]
  14. Ping, Lu. Y., et al., "Lumican expression in alpha cells of islets in pancreas and pancreatic cancer cells", J. Pathol., 196(3), 324-330 (2002). [PMID：11857496]
  15. Qin, H., et al., "Effects of the extracellular matrix on lumican expression in rat aortic smooth muscle cells in vitro", J. Pathol., 195(5), 604-608 (2001). [PMID：11745697]
  16. Baba, H., et al., "Expression and localization of lumican in the ischemic and reperfused rat heart", Jpn. Circ. J., 65(5), 445-450 (2001). [PMID： 11348051]
  17. Takayama, R., et al., "Lumican as a novel marker for differential diagnosis of Bowen disease and actinic keratosis", Am. J. Dermatopathol., 35(8), 827-832 (2013). [PMID：23719483]
  18. Takayama, R., et al., "Expression of lumican in hidroacanthoma simplex and clonal-type seborrheic keratosis as a potent differential diagnostic marker", Am. J. Dermatopathol., 36(8), 655-660 (2014). [PMID：23656908]
  19. Niiyama, S., et al., "Giant Hidroacanthoma Simplex Mimicking Bowen's Disease", Case Rep. Dermatol., 7(3), 241-244 (2015). [PMID：26500536]

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Product Information

[Date : April 25 2025 00:06]

Detail Product Name Product Code Supplier Size Price
Anti-Lumican, Human, Rabbit-Poly
DatasheetThis may not be the latest data sheet. 		FDV-0001 FNAFunakoshi Co.,Ltd. 25 µl $160

Description Lumican is a glycoprotein, consists of 338 amino acids and is a member of small leucine-rich proteoglycan (SLRP) family. Lumican contains tandem leucine-rich repeat region and its central region plays a role in N-linked glycosylation. It has been reported that overexpression of lumican is related to skin cancer, breast cancer, pancreas cancer, lung cancer, colon cancer, malignant melanoma and bone cancer. Funakoshi's anti-human lumican rabbit-poly can stain tumor part and stromal component in cancer tissues sharply.
Storage -20°C
Antigen Species Host Species Rabbit Class Label Unlabeled
Cross Reactivity Human/Rat Application IHC,Western Blot
Clonality Format Purification Affinity Purified Absorption
Link

Antibody Product List (0-M)
Antibody Product List (AGEs - Ion Channel)
Cancer-Related Antibody

[Date : April 25 2025 00:06]

Anti-Lumican, Human, Rabbit-Poly

DatasheetThis may not be the latest data sheet.


  • Product Code: FDV-0001
  • Supplier: FNA
  • Size: 25µl
  • Price: $160

Description Lumican is a glycoprotein, consists of 338 amino acids and is a member of small leucine-rich proteoglycan (SLRP) family. Lumican contains tandem leucine-rich repeat region and its central region plays a role in N-linked glycosylation. It has been reported that overexpression of lumican is related to skin cancer, breast cancer, pancreas cancer, lung cancer, colon cancer, malignant melanoma and bone cancer. Funakoshi's anti-human lumican rabbit-poly can stain tumor part and stromal component in cancer tissues sharply.
Storage -20°C
Antigen Species Host Species Rabbit
Class Label Unlabeled
Cross Reactivity Human/Rat Application IHC,Western Blot
Clonality Format
Purification Affinity Purified Absorption
Link

Antibody Product List (0-M)
Antibody Product List (AGEs - Ion Channel)
Cancer-Related Antibody

Go back to index

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