Monoclonal Antibody Against Aging Inhibitor Klotho Anti-Human Klotho Monoclonal Antibody

• Example of Use
• Features
• Reference
• Product Information

Example of Use

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Features

Name	Anti-Klotho, Human, Rat-Mono
Code	KO603	KO604
Clone	KM2076	KM2119
Antigen	Human Klotho 55-261a.a.	Human Klotho 801-954a.a.
Immunizing Animal	Rat	Rat
Purification	ProteinG	ProteinG
Isotype	IgG2a	IgG2b
Cross Reactivity	Human/Mouse/Rat	Human/Mouse
Application	IHC, Western blotting	IHC, Western blotting

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Reference

1. Kato, Y., et al., Biochem Biophys Res Commun., 19;267(2):597-602 (2000).
   "Establishment of the anti-Klotho monoclonal antibodies and detection of Klotho protein in kidneys."
2. Tohyama, O., et al., J Biol Chem. 279(11):9777-9784 (2004).
   "Klotho is a novel beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides."
3. Imura, A., et al., FEBS Lett., 565(1-3):143-147 (2004).
   "Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane."
4. Imura, A., et al., Science, 316(5831):1615-1618(2007).
   "alpha-Klotho as a regulator of calcium homeostasis."
5. Brownstein, C.A., et al., Proc. Natl. Acad. Sci. U S A, 105(9):3455-3460(2008).
   "A translocation causing increased alpha-klotho level results in hypophosphatemic rickets and hyperparathyroidism."

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Product Information

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