Leukotriene E4 MaxSpec Standard | CAS:75715-89-8

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• 製品情報
• 製品詳細
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価格

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製品情報

Leukotriene E₄ (LTE₄) is produced by the action of dipeptidase on LTD₄ (Item No. 20310), leaving only the cysteinyl group still attached to the fatty acid backbone. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A). LTE₄ is considerably less active (8- to 12-fold) than LTC₄ (Item Nos. 20210 | 10007241) in the biological activities characteristic of cysteinyl leukotrienes. Unlike LTC₄ and LTD₄, LTE₄ accumulates in both plasma and urine. Therefore, urinary excretion of LTE₄ is most often used as an indicator of asthma. In humans, basal levels of LTE₄ range from 1-100 pg/mg creatinine. In asthmatic patients, urinary LTE₄ levels increase to 80-1,000 pg/mg creatinine. All cysteinyl leukotrienes may contain a small amount of the 11-trans isomer. The purity for all such leukotrienes excludes the 1-4% trans isomer which may be present.

LTE₄ MaxSpec^® standard is a quantitative grade standard of LTE₄ (Item No. 20410) that has been prepared specifically for mass spectrometry or any application where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed underargon. The concentration was verified by comparison to an independently prepared calibration standard. This LTE₄ MaxSpec^® standard is guaranteed to meet identity, purity, stability, and concentrationspecifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.

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製品詳細

name	Leukotriene E4 MaxSpec Standard
Formal Name	5S-hydroxy-6R-(S-cysteinyl)-7E,9E,11Z,14Z-eicosatetraenoic acid
CAS Number	75715-89-8
Synonyms	LTE4
Molecular Formula	C23H37NO5S
Formula Weight	439.6
Purity	≥95%
Formulation	A solution in ethanol
SMILES	CCCCC/C=C\C\C=C/C=C\C=C/C(SCC(N)C(=O)O)[C@@H](O)CCCC(=O)O
Storage	-80°C
Shipping	Dry ice in continental US; may vary elsewhere
Stability	≥ 1 year

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文献

1. Bernström, K., and Hammarström, S. Metabolism of leukotriene D by porcine kidney. J. Biol. Chem. 256(18), 9579-9582 (1981).

2. Samuelsson, B. Leukotrienes: Mediators of immediate hypersensitivity reactions and inflammation. Science 220(4597), 568-575 (1983).

3. Lefer, A.M. Leukotrienes as mediators of ischemia and shock. Biochem. Pharmacol. 35(2), 123-127 (1986).

4. Kumlin, M., Stensvad, F., Larsson, L., et al. Validation and application of a new simple strategy for measurements of urinary leukotriene E4 in humans. Clin. Exp. Allergy 25(5), 467-479 (1995).

5. Drazen, J.M., O'Brien, J., Sparrow, D., et al. Recovery of leukotriene E4 from the urine of patients with airway obstruction. Am. Rev. Respir. Dis. 146(1), 104-108 (1992).

6. Kumlin, M., Dahlén, B., Björck, T., et al. Urinary excretion of leukotriene E4 and 11-dehydro-thromboxane B2 in response to bronchial provocations with allergen, aspirin, leukotriene D4, and histamine in asthmatics. Am. Rev. Respir. Dis. 146(1), 96-103 (1992).

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