Prostaglandin F2α Ethanolamide MaxSpec Standard | CAS:353787-70-9

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価格

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製品情報

Prostaglandin F_2α ethanolamide (PGF_2α-EA) is produced by cyclooxygenase 2 (COX-2) metabolism of the endogenous cannabinoid, arachidonoyl ethanolamide (AEA; Item No. 90050), found in brain, liver, and other mammalian tissues. AEA can be metabolized directly by the sequential action of COX-2 and specific PG synthases to produce ethanolamide congeners of the classical PGs. PGF_2α-EA has also been reported to be biosynthesized by this mechanism when AEA was infused into the lung and liver of living mice. PGF_2α-EA is a potent dilator (EC₅₀ = 58 nM) of the cat iris sphincter, which is a model system for testing potential intraocular hypotensive agents.

PGF_2α-EA MaxSpec^® standard is a quantitative grade standard of PGF_2α-EA (Item No. 16013) that has been prepared specifically for mass spectrometry or any application where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This PGF_2α-EA MaxSpec^® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.

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製品詳細

name	Prostaglandin F2α Ethanolamide MaxSpec Standard
Formal Name	N-(2-hydroxyethyl)-9α,11α,15S-trihydroxy-prosta-5Z,13E-dien-1-amide
CAS Number	353787-70-9
Synonyms	Dinoprost Ethanolamide PGF2α-EA
Molecular Formula	C22H39NO5
Formula Weight	397.5
Purity	≥95%
Formulation	A solution in ethanol
SMILES	CCCCCC(O)/C=C/[C@H]1C(O)CC(O)C1C/C=C\CCCC(=O)NCCO
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
Stability	≥ 1 year

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文献

1. Bachur, N.R., Masek, K., Melmon, K.L., et al. Fatty acid amides of ethanolamine in mammalian tissues. J. Biol. Chem. 240, 1019-1024 (1965).

2. Yu, M., Ives, D., and Ramesha, C.S. Synthesis of prostaglandin E2 ethanolamide from anandamide by cyclooxygenase-2. J. Biol. Chem. 272(34), 21181-21186 (1997).

3. Kozak, K.R., Crews, B.C., Morrow, J.D., et al. Metabolism of the endocannabinoids, 2-arachidonylgycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides. J. Biol. Chem. 277(47), 44877-44885 (2002).

4. Woodward, D.F., Tang-Liu, D.D.S., Madhu, C., et al. Prostaglandin F2α (PGF2α) 1-ethanolamide: A pharmacologically unique local hormone biosynthesized from anandamide. 11th International Conference on Advances in Prostaglandin and Leukotriene Research: Basic Science and New Clinical Applications 27 (2000).

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