Prostaglandin F2α MaxSpec Standard | CAS:551-11-1

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• 製品情報
• 製品詳細
• 文献

価格

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製品情報

Prostaglandin F_2α (PGF_2α) is a widely distributed PG occurring in many species. It causes contraction of vascular, bronchial, intestinal, and myometrial smooth muscle, and also exhibits potent luteolytic activity. PGF_2α exerts its receptor mediated physiological activity at 50-100 nM. Maximal ovine myometrial contraction can be achieved at 125 nM PGF_2α in vitro.

PGF_2α MaxSpec^® standard is a quantitative grade standard of PGF_2α (Item No. 16010) that has been prepared specifically for mass spectrometry or any application where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This PGF_2α MaxSpec^® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.

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製品詳細

name	Prostaglandin F2α MaxSpec Standard
Formal Name	9α,11α,15S-trihydroxy-prosta-5Z,13E-dien-1-oic acid
CAS Number	551-11-1
Synonyms	Dinoprost PGF2α
Molecular Formula	C20H34O5
Formula Weight	354.5
Purity	≥95%
Formulation	A solution in methyl acetate
SMILES	CCCCCC(O)/C=C/[C@H]1C(O)CC(O)C1C/C=C\CCCC(=O)O
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
Stability	≥ 1 year

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文献

1. Speroff, L., and Ramwell, P.W. Prostaglandins in reproductive physiology. Am. J. Obstet. Gynecol. 107(7), 1111-1130 (1970).

2. Samuelsson, B., Goldyne, M., Granström, E., et al. Prostaglandins and thromboxanes. Annu. Rev. Biochem. 47, 997-1029 (1978).

3. Watanabe, K., Iguchi, Y., Iguchi, S., et al. Stereospecific conversion of prostaglandin D2 to (5Z,13E)-(15S)-9α,-11β,15-trihydroxyprosta-5,13-dien-1-oic acid (9α,11β-prostaglandin F2) and of prostaglandin H2 to prostaglandin F2α by bovine lung prostaglandin F synthase. Proc. Natl. Acad. Sci. U.S.A. 83(6), 1583-1587 (1986).

4. Crankshaw, D.J., and Gaspar, V. Pharmacological characterization in vitro of prostanoid receptors in the myometrium of nonpregnant ewes. J. Reprod. Fertil. 103(1), 55-61 (1995).

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