15-keto Prostaglandin E2 MaxSpec Standard | CAS:26441-05-4

• 価格
• 製品情報
• 製品詳細
• 文献

価格

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製品情報

15-keto Prostaglandin E₂ (15-keto PGE₂) is a metabolite of PGE₂ (Item Nos. 14010 | 10007211) formed by 15-hydroxy PGDH (Item No. 360615). In vivo, 15-keto PGE₂ is essentially inactive. It has an attenuated affinity for the EP₄ and EP₂ receptors compared to PGE₂ (K_i = 2,600-15,000 nM for the inhibition of PGE₂ binding compared to a K_d = 1 nM for PGE₂).

15-keto PGE₂ MaxSpec^® standard is a quantitative grade standard of 15-keto PGE₂ (Item No. 14720) that has been prepared specifically for mass spectrometry or any application where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This 15-keto PGE₂ MaxSpec^® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.

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製品詳細

name	15-keto Prostaglandin E2 MaxSpec Standard
Formal Name	9,15-dioxo-11α-hydroxy-prosta-5Z,13E-dien-1-oic acid
CAS Number	26441-05-4
Synonyms	15-keto PGE2
Molecular Formula	C20H30O5
Formula Weight	350.5
Purity	≥95%
Formulation	A solution in methyl acetate
SMILES	CCCCCC(=O)\C=C/[C@H]1C(O)CC(=O)C1C/C=C\CCCC(=O)O
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
Stability	≥ 1 year

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文献

1. Hamberg, M., and Samuelsson, B. On the metabolism of prostaglandins E1 and E2 in man. J. Biol. Chem. 246(22), 6713-6721 (1971).

2. Mak, O.T., Liu, Y., and Tai, H.H. Purification and characterization of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase from porcine kidney. Biochim. Biophys. Acta 1035(2), 190-196 (1990).

3. Nishigaki, N., Negishi, M., and Ichikawa, A. Two Gs-coupled prostaglandin E receptor subtypes, EP2 and EP4, differ in desensitization and sensitivity to the metabolic inactivation of the agonist. Mol. Pharmacol. 50(4), 1031-1037 (1996).

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