6-keto Prostaglandin E1 MaxSpec Standard | CAS:67786-53-2

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• 製品情報
• 製品詳細
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価格

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製品情報

6-keto Prostaglandin E₁ (6-keto PGE₁) is a stable non-enzymatic hydrolysis product of prostacyclin (PGI₂; Item No. 18220). 6-keto PGE₁ is a metabolite isolated after the incubation of PGI₂ with rabbit liver microsomes. However, it is not produced in appreciable amounts following IV infusion of PGI₂ in humans. 6-keto PGE₁ is equipotent with PGI₂ as a vasodilator; in most other aspects its activity resembles PGE₁ (Item No. 13010).

6-keto PGE₁ MaxSpec^® standard is a quantitative grade standard of 6-keto PGE₁ (Item No. 13260) that has been prepared specifically for mass spectrometry or any application where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This 6-keto PGE₁ MaxSpec^® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.

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製品詳細

name	6-keto Prostaglandin E1 MaxSpec Standard
Formal Name	6,9-dioxo-11α,15S-dihydroxy-prost-13E-en-1-oic acid
CAS Number	67786-53-2
Synonyms	6-keto PGE1
Molecular Formula	C20H32O6
Formula Weight	368.5
Purity	≥95%
Formulation	A solution in ethanol
SMILES	CCCCCC(O)/C=C/[C@H]1C(O)CC(=O)C1CC(=O)CCCCC(=O)O
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
Stability	≥ 1 year

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文献

1. Wong, P.Y.K., Malik, K.U., Desiderio, D.M., et al. Hepatic metabolism of prostacyclin (PGI2) in the rabbit: Formation of a potent novel inhibitor of platelet aggregation. Biochem. Biophys. Res. Commun. 93(2), 486-494 (1980).

2. Jackson, E.K., Goodman, R.P., Fitzgerald, G.A., et al. Assessment of the extent to which exogenous prostaglandin I2 is converted to 6-keto-prostaglandin E1 in human subjects. J. Pharmacol. Exp. Ther. 221(1), 183-187 (1982).

3. Adaikan, P.G., Tai, M.Y., Lau, L.C., et al. A comparison of some pharmacological actions of prostaglandin E1, 6-oxo-PGE1 and PGI2. Prostaglandins 27(4), 505-516 (1984).

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