13,14-dihydro-15-keto Prostaglandin D2 MaxSpec Standard | CAS:59894-07-4

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• 製品情報
• 製品詳細
• 文献

価格

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製品情報

13,14-dihydro-15-keto Prostaglandin D₂ (13,14-dihydro-15-keto PGD₂) is a metabolite of PGD₂ (Item Nos. 12010 | 10007202) which is formed through the 15-hydroxy PGDH pathway. 13,14-dihydro-15-keto PGD₂ was recently identified as a selective agonist for the CRTH2/DP₂ receptor. It also inhibits ion flux in a canine colonic mucosa preparation. In humans, 13,14-dihydro-15-keto PGD₂ is further metabolized to give 11β-hydroxy compounds which have also undergone β-oxidation of one or both side chains. Virtually no 13,14-dihydro-15-keto PGD₂ survives intact in the urine.

13,14-dihydro-15-keto PGD₂ MaxSpec^® standard is a quantitative grade standard of 13,14-dihydro-15-keto PGD₂ (Item No. 12610) that has been prepared specifically for mass spectrometry or any application where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This 13,14-dihydro-15-keto PGD₂ MaxSpec^® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.

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製品詳細

name	13,14-dihydro-15-keto Prostaglandin D2 MaxSpec Standard
Formal Name	9α-hydroxy-11,15-dioxo-prost-5Z-en-1-oic acid
CAS Number	59894-07-4
Synonyms	13,14-dihydro-15-keto PGD2
Molecular Formula	C20H32O5
Formula Weight	352.5
Purity	>95%
Formulation	A solution in methyl acetate
SMILES	CCCCCC(=O)CC[C@H]1C(=O)CC(O)C1C/C=C\CCCC(=O)O
Storage	-80°C
Shipping	Dry ice in continental US; may vary elsewhere
Stability	≥ 1 year

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文献

1. Rangachari, P.K., and Betti, P.A. Biological activity of metabolites of PGD2 on canine proximal colon. Am. J. Physiol. 264(5 Pt 1), G886-G894 (1993).

2. Hirai, H., Tanaka, K., Yoshie, O., et al. Prostaglandin D2 selectivity induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. J. Exp. Med. 193(2), 255-261 (2001).

3. Liston, T.E., and Roberts, L.J., II. Metabolic fate of radiolabeled prostaglandin D2 in a normal human male volunteer. J. Biol. Chem. 260(24), 13172-13180 (1985).

4. Morrow, J.D., Prakash, C., Awad, J.A., et al. Quantification of the major urinary metabolite of prostaglandin D2 by a stable isotope dilution mass spectrometric assay. Anal. Biochem. 193(1), 142-148 (1991).

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