Prostaglandin D2 Ethanolamide MaxSpec Standard | CAS:398138-28-8

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• 製品詳細
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価格

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製品情報

Prostaglandin D₂ ethanolamide (PGD₂-EA) is a bioactive lipid produced by the sequential metabolism of anandamide (arachidonoyl ethanolamide; Item Nos. 90050 | 10007270) by cyclooxygenase (COX) enzymes, in particular by COX-2, and PGD synthase. The biosynthesis of PGD₂-EA from anandamide can also be increased when anandamide metabolism is diminished by deletion of fatty acid amide hydrolase. PGD₂-EA is inactive against recombinant prostanoid receptors, including the D prostanoid receptor. It increases the frequency of miniature inhibitory postsynaptic currents in primary cultured hippocampal neurons, an effect which is the opposite of that induced by anandamide. PGD₂-EA also induces apoptosis in colorectal carcinoma cell lines.

PGD₂-EA MaxSpec^® standard is a quantitative grade standard of PGD₂-EA (Item No. 12012) that has been prepared specifically for mass spectrometry or any application where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampulesealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This PGD₂-EA MaxSpec^® standard is guaranteed to meet identity, purity, stability, andconcentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product.Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.

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製品詳細

name	Prostaglandin D2 Ethanolamide MaxSpec Standard
Formal Name	N-(2-hydroxyethyl)-11-oxo-9α,15S-dihydroxy-prosta-5Z,13E-dien-1-amide
CAS Number	398138-28-8
Synonyms	PGD2-EA Prostamide D2
Molecular Formula	C22H37NO5
Formula Weight	395.5
Purity	≥95%
Formulation	A solution in ethanol
SMILES	CCCCCC(O)/C=C/[C@H]1C(=O)CC(O)C1C/C=C\CCCC(=O)NCCO
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
Stability	≥ 1 year

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文献

1. Kozak, K.R., Crews, B.C., Morrow, J.D., et al. Metabolism of the endocannabinoids, 2-arachidonylgycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides. J. Biol. Chem. 277(47), 44877-44885 (2002).

2. Patsos, H.A., Hicks, D.J., Dobson, R.R.H., et al. The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells: A possible role for cyclooxygenase 2. Gut 54(12), 1741-1750 (2005).

3. Sang, N., Zhang, J., and Chen, C. PGE2 glycerol ester, a COX-2 oxidative metabolite of 2-arachidonoyl glycerol, modulates inhibitory synaptic transmission in mouse hippocampal neurons. J. Physiol. 572(Pt 3), 735-745 (2006).

4. Weber, A., Ni, J., Ling, K.H.J., et al. Formation of prostamides from anandamide in FAAH knockout mice analyzed by HPLC with tandem mass spectrometry. J. Lipid. Res. 45(4), 757-763 (2004).

5. Matias, I., Chen, J., De Petrocellis, L., et al. Prostaglandin ethanolamides (prostamides): In vitro pharmacology and metabolism. J. Pharmacol. Exp. Ther. 309(2), 745-757 (2004).

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