抗Progesterone R/NR3C3 [p Ser190] (EP1516Y)抗体 | Anti-Progesterone R/NR3C3 [p Ser190] (EP1516Y) Antibody

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Image

	Western Blot: Progesterone Receptor [p Ser190] Antibody (EP1516Y) [NB100-80036] T47D cell lysates, 1:10,000 dilution. Cells were either (A) untreated (B) treated with progesterone.
	Immunohistochemistry: Progesterone Receptor [p Ser190] Antibody (EP1516Y) [NB100-80036] - Immunohistochemical analysis of paraffin-embedded human breast carcinoma using anti-Phospho-PR.

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Background

The human progesterone receptor (PR), is a ligand-activated transcription factor and is a member of the steroid receptor family (1). PR exists in humans as two isoforms; PR-A (94 kDa) which lacks the first 164 amino acids of PR-B and PR-B (114 kDa)(2-3). While the two forms of PR have similar DNA- and ligand-binding affinities they have opposite transcriptional activities. PR-B functions as an activator of progesterone-responsive genes, while PR-A functions as a strong transdominant repressor of PR-B (4). Human progesterone receptor (PR) is phosphorylated on multiple serine residues (at least seven sites) in a manner that involves distinct groups of sites coordinately regulated by hormone and different kinases. As detected by Western blot of T47D cells treated with hormone for different times, hormone-dependent down-regulation of total PR and the Ser 190 phosphorylation site occurred in parallel, whereas the Ser 294 phosphorylation site was down-regulated more rapidly (5)

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