抗Cyclin D1 (EPR2241)抗体 | Anti-Cyclin D1 (EPR2241) Antibody

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Image

	Western Blot: Cyclin D1 Antibody (EPR2241) [NB100-79920] - Lane 1 : Mouse kidney. Lane 2 : Mouse spleen. Lane 3 : Rat heart.
	Immunocytochemistry/Immunofluorescence: Cyclin D1 Antibody (EPR2241) [NB100-79920] - MCF7 cells.
	Immunohistochemistry-Paraffin: Cyclin D1 Antibody (EPR2241) [NB100-79920] - Staining of paraffin embedded human endometrial adenocarcinoma. PBS was used instead of the primary antibody as the negative control, and is shown in the inset.
	Western Blot: Cyclin D1 Antibody (EPR2241) [NB100-79920] - MG-63 cells.
	Western Blot: Cyclin D1 Antibody (EPR2241) [NB100-79920] - MCF-7 cell lysate using a 1:50,000 dilution.
	Western Blot: Cyclin D1 Antibody (EPR2241) [NB100-79920] - Lane 1 : Human osteosarcoma whole cell lysate - control, non-targeting siRNA. Lane 2 : Human osteosarcoma whole cell lysate - siRNA for Cyclin D1.
	Immunocytochemistry/Immunofluorescence: Cyclin D1 Antibody (EPR2241) [NB100-79920] - Staining Cyclin D1 in human HeLa cell.
	Immunohistochemistry: Cyclin D1 Antibody (EPR2241) [NB100-79920] - Immunohistochemical analysis of paraffin-embedded human mantle cell lymphoma using Cyclin D1 Antibody.
	Immunoprecipitation: Cyclin D1 Antibody (EPR2241) [NB100-79920] - A431 cells.

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Background

Cyclin D1 belongs to the Cyclin D family. Cyclin D1 is required for the cell cycle G1/S transition (1). Cyclin D1 forms a serine/threonine kinase holoenzyme complex with and functions as a regulatory subunit of CDK4 or CDK6. Cyclin D1 also phosphorylates and inactivates the retinoblastoma protein and promotes progression through the G1/S phase (2-3). Amplification or overexpression of cyclin D1 plays a pivotal role in the development of various human cancers including parathyroid adenoma, breast cancer, colon cancer, lymphoma, melanoma, and prostate cancer (4). Over-expression of cyclin D1 is known to correlate with the early onset of cancer and risk of tumor progression and metastasis (5). Cyclin D1 also associates with, and regulates the activity of transcription factors, coactivators and corepressors that govern histone acetylation and chromatin remodeling proteins (6-7)

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